Hey Fredd, I was wondering if you know anything about this: How hard is it for the body to attach the adenosyl group to cobalamin to generate aB12 ?
I am asking this because I am wondering if I am the only one experiencing more benefits from mB12 than aB12 ? On days that I take mB12 alone, I do not feel any or much worse compared to days I take it together with 3,6, or 9mg of aB12 (Country Life).
I know that adenosine generated from the ATP cycle wiill need to bind to the cobalamin corrin ring before it becomes active aB12. But apart from cyano and hydroxy supplements out there, there is yet another supplement sold - straight cobalamin (Solgar B12). This product would reduce the enzymatic step even further from cyano, hydroxy supplements before they get to cobalamin. So my question is this, is Cobalamin by itself also another active form of B12 that we just dont know much about ? That is what mB12 eventually ends up as anyway after demethylation.
Also another thing that i was thinking about is that since there is no bonding of the the cobalamin to a substitution group, there is no weak bond to be concerned about and cobalamin can just be taken orally without the need for injections or sublingual.
Hi Undcvr,
I am asking this because I am wondering if I am the only one experiencing more benefits from mB12 than aB12 ?
Be careful of misinterpreting what you perceive. Adb12 is very different from mb12. Typically a person feels mild startup for the first dose or two only and nothing at all on an ongoing basis as long as equilibrium is maintained. If one doesn't take adb12 for a month, then mild startup might be perceived. You see, adb12 does two things, occupies the mitochondria which produces energy and helps form myelin. The adb12 stays in the mitochondria once it is there so there is not a regular turnover. Deficiency symptoms of adb12 only come back very slowly, especially the only noticeable effects, the energy producing function. Mb12 on the other hand circulates and is dumped out of the body rapidly, so some people can feel an effect from each tablet until they get to a high body equilibrium. When you can't feel the adb12 that means it is doing it's job. You may find that taking one adb12 per week is quite sufficient to maintain body/mitochondria equilibrium. It gets more questionable when it comes to myelin and CNS equilibrium. I have experimented with adb12 from quite a bit per day timed for CNS penetration with my mb12 injections to once per week. Some people say "I need 5 per day" every day to banish brainfog. SOme find 1 per day to 1 per week entirely satisfactory.
Mb12 deficiency symptoms start coming back within 3 days of not taking any for many people. Until a high level of equilibrium is reached, some people will feel every dose of mb12.
there is yet another supplement sold - straight cobalamin (Solgar B12).
is Cobalamin by itself also another active form of B12 that we just dont know much about
I don't believe that to be the case. Solgar sells methylcobalamin. It also sells something at a lower cost as "b12" from "cobalamin" but unspecified "b12" or "cobalamin" is ALWAYS cyanocobalamin, at least in the USA.
The Solgar mb12 hasn't been tested by me originally. And with the high dose I take, I can't distinguish these things as I could when I was severely deficient.
In any case, most of the healing appears to be casused by circulating adb12 and circulating mb12 which can diffuse into the cells immediately as needed rather than having to be squeezed through a keyhole of enzyme conversion which is severely limited.
