Any news on Lipkin study?

[Daffodil]

thats why GcMAF works..it targets B cells that are marked by viruses!!!

 

[alex3619]

Too tired to comment much now, but I read just in the last day or two of a study in which a deficiency of just one key immune protein can lead to persistent viral infection. I don't recall the article though, only that this was mostly on mice. I just searched my email for it but it wasnt there.

 

[Glynis Steele]

Here it is, hun.

http://forums.phoenixrising.me/inde...o-lifelong-viral-infection.17965/#post-273824

http://medicalxpress.com/news/2012-06-scientists-lack-protein-results-persistent.html

 

[Ema]

Please note that posts on Rituximab can now be found here:

http://forums.phoenixrising.me/index.php?threads/rituximab-discussion.18028/

 

[Bob]

If anyone is interested in exploring Rituximab and its implications, then please pop over to the other thread with me.

 

[acer2000]

I know Peterson likes to talk occasionally, but I seriously doubt he knows the results of the Lipkin xmrv study. My understanding is that his role in the XMRV/MLV study being done with Columbia was limited to supplying patient samples and matched controls from his practice/area.

 

[Esther12]

If they're at the point of finalising the paper and getting it peer reviewed, it wouldn't surprise me if everyone involved now knew the result.

 

[Bob]

More of the same from Simmaron:

XMRV and MLV in Chronic Fatigue Syndrome

Funded by: The National Institutes of Health (NIH)
While bringing conclusion to the XMRV debate, this study creates well-defined patient cohorts from multiple sites under the leadership of Columbia University’s Mailman School of Public Health and the Centers for Infection and Immunity.
http://simmaronresearch.com/sr-research/?forumid=331851

 

[beaverfury]

http://medicalxpress.com/news/2012-06-scientists-lack-protein-results-persistent.html
ooh.. thats interesting. Imiquimod works on TLR7 according to wiki.

..And this implicates TLR4,
http://www.proteabiopharma.com/page/cfs-me.php
..For which Naloxone and Amitriptyline are antagonists.

Whats it all mean?.....I dont know. But i'll take anything.

However, i digress. Back to Lipkin

 

[beaverfury]

..its ok, i wont really take anything. I can wait for those scientists to come up with something.
They'll get there.....five years.... . Ten years max.

Sit back and enjoy my full and varied life until then

 

[free at last]

http://medicalxpress.com/news/2012-06-scientists-lack-protein-results-persistent.html
ooh.. thats interesting. Imiquimod works on TLR7 according to wiki.

..And this implicates TLR4,
http://www.proteabiopharma.com/page/cfs-me.php
..For which Naloxone and Amitriptyline are antagonists.

Whats it all mean?.....I dont know. But i'll take anything.

However, i digress. Back to Lipkin

I wonder if there has been research on TLR7 and Amitriptyline effects on the protien
I know its a pain killer. But was wondering about its possible effect on this missing or dysfunctional protien
As i did well on Amitriptyline. And not just in a non depressive way. Ive been saying that here for years. But i am out of my depth. there may be no research showing any benefit on TLR7 problems. Just thought i would mention the idea ?

 

[Firestormm]

First appeared: http://www.mecfsforums.com/index.php/topic,13221.new.html#new

Also now: http://www.prohealth.com/library/showarticle.cfm?libid=17175

From Centre for Infection and Immunity:

Dr Ian Lipkin - XMRV / MLV Study to be published on the 18th of Sept 2012

@CII722

#XMRV/#CFS/#ME study is complete. Was accepted for publication last week. Is due for release on Sept. 18.

CII ‏@CII722

@newprof1 @cggbamford We prefer the "Alter/Mikovits/Switzer/Lipkin" study , but yes.

Follow
CII

@CII722

The Center for Infection & Immunity is dedicated to pathogen surveillance & grasping how gene-environment-timing interactions contribute to health & disease.

https://twitter.com/CII722

So. I've noted it in me diary. Unless someone who better understand Twitter can tell me this isn't genuine

 

[snowathlete]

I was on amitryptyline for sleep. 20mg and it helped loads. I stopped two months ago because I had to look after my daughter while my wife had appendicitis. Daughter doesn't sleep well and needs rocking all night.
Sleep has slowly declined since. I may go back on them but was enjoying being off all tablets. Also I know I feel dreadful the first two weeks back on them so avoiding it.
So this research suggests it may be good for ME?
On a general note I have been feeling worse off it overall.

 

[beaverfury]

18th SEPTEMBER. Awesome. It will be like sitting up waiting for the Wimbledon final. I MIGHT EVEN DRINK A BEER!

Best case scenario: We Will All Be Cured in a Couple of Weeks.

As for the Amitriptyline, for gods sake dont listen to me. TLR-4 detects lipopolysaccharide and produces an inflammatory response. Whether this response is a good thing in cfs, i dont know.
Wiki lists Ketotifen and Amitriptyline as antagonists which would presumably turn down this response.
I should stick to drinking beeer, and not engage in medical speculation.

 

[leela]

the comments "bringing conclusion to the XMRV debate" and "draw a line under"
don't necessarily translate to "rule out" to me. Draw a line through, that's a no. Bringing conclusion to the debate
could be a yea or a nay. Drawing a line under is for emphasis. I read it as possibly a subset in which MLVs can be a factor. Or not.

I'm quoting myself, because I was just watching a movie the other day wherein a character used "draw a line under" in the sense of crossing it off the list. I have never heard that before, but of course, I don't get out much

Anyhow, it's such a short wait now to see the study. I hope we get some solid info for moving forward,
whatever the results.

 

[barbc56]

I'm quoting myself, because I was just watching a movie the other day wherein a character used "draw a line under" in the sense of crossing it off the list. I have never heard that before, but of course, I don't get out much

Anyhow, it's such a short wait now to see the study. I hope we get some solid info for moving forward,
whatever the results.

I always thought "draw a line under" was for emphasis thus the phrase "the bottom line". But then I also thought the Lipkin study was coming out on the 28th. I think this is the first time my fog has had a positive outcome.

Of course now I have to stop doing anything productive and find the phrase on the internet, etc., etc. etc.

I don't get out much, either.

Barb C.:>)

Now this has led me to wonder about the phrase "drawing a line in the sand" and how it's related to the above. Learning new things is a never ending battle.

 

[In Vitro Infidelium]

I'm quoting myself, because I was just watching a movie the other day wherein a character used "draw a line under" in the sense of crossing it off the list.

http://oxforddictionaries.com/definition/english/draw
draw a line under

resolve not to engage in further discussion or consideration of (a difficult or distressing issue or situation): we need to draw a line under this whole affair, not prolong it

​

The orgin is I think mathematics/accountancy - a heavy horizontal line denoting the end of a calculation or accounting series. Anything that follows, although it may use data derived from above the line (for example a closing balance), is considered to operate under different conditions to that which applied to the calculations made above the line. A completed calculation may of course get a 'tick' from the auditor, teacher or examiner, and the completed work may be 'crossed off' the work list. In printing a heavy line was once standard at the end of a book chapter, and of course still denotes the end of an article in some print media.​

​

​

 

[barbc56]

http://oxforddictionaries.com/definition/english/draw
draw a line under

resolve not to engage in further discussion or consideration of (a difficult or distressing issue or situation): we need to draw a line under this whole affair, not prolong it

​

The orgin is I think mathematics/accountancy - a heavy horizontal line denoting the end of a calculation or accounting series. Anything that follows, although it may use data derived from above the line (for example a closing balance), is considered to operate under different conditions to that which applied to the calculations made above the line. A completed calculation may of course get a 'tick' from the auditor, teacher or examiner, and the completed work may be 'crossed off' the work list. In printing a heavy line was once standard at the end of a book chapter, and of course still denotes the end of an article in some print media.​

​

CM​

Thanks!!

Barb C.:>)

 

[leela]

Well, at least now we've got the English sorted.
On to the science ........

 

[Bob]

Well, at least now we've got the English sorted.
On to the science ........

So, shall we, ehem, draw a line under the English discussion now then?!? hehehe...


(Disclaimer: Sorry, that was my poor attempt at a joke... I'm not attempting to stop any English discussions! My jokes don't always translate well onto forums, so it's best that I point out that it's my attempt at a joke!)