Abilify tolerance

Messages
87
Likes
292
Location
France
buy-pharma.md do not ship to France. Goldpharma.cn apparently require a prescription. I'll just have to wait this out and ask my doctor. If anyone knows of a way to ship to France online without a prescription, keep me in the know. Thanks.
 
Messages
2,053
Likes
6,007
buy-pharma.md do not ship to France. Goldpharma.cn apparently require a prescription. I'll just have to wait this out and ask my doctor. If anyone knows of a way to ship to France online without a prescription, keep me in the know. Thanks.
I think it's not possible in the whole EU anymore
 

nsdn

Senior Member
Messages
150
Likes
85
@Hip or others.

I take Abilify 0.5 mg in the morning. I got a prescription for liquid Amisulpride in Spain.

What time should I take Amisulpride?

Should I go slowly or start with 12.5 mg all at once?

Thanks.
 

leokitten

Senior Member
Messages
1,395
Likes
3,470
Location
U.S.
Second.. why do you want to combine it?
I do not think it makes sense to combine them, you aren’t going to get additive effects, amisulpride has specifically a very different serotonin receptor binding profile compared to aripiprazole so you could be canceling things out and I also doubt effects dopamine are going to be additive. I would take either or, not both.
 
Last edited:

nsdn

Senior Member
Messages
150
Likes
85
Thank you all for your contributions. Abilify 0.5 mg. every morning has improved me a lot since June but I'm afraid it will stop working. Would it make sense to alternate Abilify and Amisulpride? Maybe one every week? Best regards.
 
Messages
2,053
Likes
6,007
Thank you all for your contributions. Abilify 0.5 mg. every morning has improved me a lot since June but I'm afraid it will stop working. Would it make sense to alternate Abilify and Amisulpride? Maybe one every week? Best regards.
That's an interesting idea but I fear due to it's long half-life and diametral effects on receptors it will not only interact but also not be of any benefit.
 

nsdn

Senior Member
Messages
150
Likes
85
Now I think that due to the long life of Abilify it might be better to try alternating every 2 weeks.
 
Messages
27
Likes
62
Location
UK
Thank you very much, but the problem is not so much to fall aspleep, it‘s more about sleeping long enough. Most of the time he sleeps early but just a few hours and then he can‘t find sleep again. So we are looking for something that could help longterm. Thats why real sleep meds are not an option.
I'll mention mirtazapine, since nobody else has. It's an antidepressant, but for whatever it's worth, I started it on top of another antidepressant (venlafaxine) at high dose (30mg) and don't notice any additional antidepressant effects from it. But as a sleep inducer, it is powerful. Problem though is the long half-life - you're grogged out all day. To counter that I take a modest dose (600mg) of adrafinil - doesn't help my fatigue but does counter the mirtazapine nicely :thumbsup:
 
Messages
27
Likes
62
Location
UK
It doesn’t take a big mental leap from this to postulate that even if you aren’t crashing on Abilify you could still be chronically overexerting and not realize it, all the while it having a big negative effect on the disease process until suddenly the drug doesn’t work anymore.
The Stanford study used doses up to 2mg if I recall correctly. I understand the idea is to leverage some dose-dependent features of Abilify, but I think it would be worth exploring more traditional Abilify doses for anyone who previously responded to low doses. A proper trial of Abilify up to a more standard dose (preferably under the supervision of a doctor) might be worthwhile.
Hmm. Not sure if there's any value in recounting my personal experience but here goes:
- Psychosis (dopamine...) and/or head injury as trigger for ME/CFS (best guess)
- Started abilify 15mg
- First year few/no symptoms (abilify working?)
- Early part of second year hypersomnia; unrefreshing sleep; constant fatigue but able to go for long-ish walks and work out moderately without noticeably inducing PEM
- Later part of second year abrupt switch to insomnia; easily-induceable PEM; become housebound

Maybe nothing there, idk. Take fwiw.