It doesn’t take a big mental leap from this to postulate that even if you aren’t crashing on Abilify you could still be chronically overexerting and not realize it, all the while it having a big negative effect on the disease process until suddenly the drug doesn’t work anymore.
The Stanford study used doses up to 2mg if I recall correctly. I understand the idea is to leverage some dose-dependent features of Abilify, but I think it would be worth exploring more traditional Abilify doses for anyone who previously responded to low doses. A proper trial of Abilify up to a more standard dose (preferably under the supervision of a doctor) might be worthwhile.
Hmm. Not sure if there's any value in recounting my personal experience but here goes:
- Psychosis (dopamine...) and/or head injury as trigger for ME/CFS (best guess)
- Started abilify 15mg
- First year few/no symptoms (abilify working?)
- Early part of second year hypersomnia; unrefreshing sleep; constant fatigue but able to go for long-ish walks and work out moderately without noticeably inducing PEM
- Later part of second year abrupt switch to insomnia; easily-induceable PEM; become housebound
Maybe nothing there, idk. Take fwiw.