Abilify tolerance

[Pendergast]

@leokitten how are you doing? Is your second chance with Abilify still working? (I hope so)

 

[pattismith]

So
for most of us (2/3?) Abilify builds up (pharmarkokinetic?) tolerance.
Any theories why?
Maybe workarounds possible?

Let's discuss it.
@Hip @leokitten ?

Best of all
Martin

Has anyone ever consider brain insulin resistance as a potential driver for Aripiprazole tolerance?

Antipsychotics differentially regulate insulin, energy sensing, and inflammation pathways in hypothalamic rat neurons - PubMed (nih.gov)

 

[hmnr asg]

but he suggested Rexulti. So I’m going off Abilify and starting that soon. All my doctors said that the half life of Abilify is so long you don’t need to taper it. But that doesn’t invalidate your withdrawal symptoms.

Hey Whit,
How did rexulti end up working ?