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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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has anyone tried low dose Abilify with an antidepressan
The Stanford study found no statistically significant effect of concurrent antidepressant use on Abilify's effectiveness in ME/CFS:
"The difference in antidepressant use between responders vs. non-responders was not statistically significant (p = 0.145) using the test for proportions, suggesting that antidepressant use does not predict or preclude a clinical response to aripiprazole."
(note: antinociceptive = decreasing sensory/pain sensitivity)The injection of cGMP-specific phosphodiesterase type 5 inhibitor zaprinast, potentiated the antinociceptive effect induced by a low dose of aripiprazole.
The statement that olanzapine increases the mRNA of D2R and increases the binding of DAT refers to the drug's mode of action at the cellular level. mRNA (messenger RNA) is a type of RNA that serves as a template for protein biosynthesis. In this case, the statement refers to the production of D2R, a specific type of dopamine receptor. Increasing the mRNA of D2R would lead to increased production of these receptors.
There has been some discussion about the mechanism of action of the atypical neuroleptics olanzapine (Zyprexa, ziprasidone (Geodon), risperidone (Risperdal), and quetiapine (Seroquel). These drugs are 5-HT2 receptor antagonists. Olanzapine and risperidone bind to dopamine D2 and D4 receptors and, therefore, elevate the levels of D2 receptors, particularly in the basal ganglia. This finding is consistent with the ability of olanzapine and risperidone to induce extrapyramidal side effects.
When dealing with a patient made sleepy by stimulants or who develops rapid tolerance to them, there is always the question of whether to desensitize the D2 autoreceptors with a D2/D3 agonist (some autoreceptors are of the D3 variety) or to block hypersensitive autoreceptors with haloperidol, which, unfortunately, is not D2 selective enough for this purpose, blocking D3 receptors also.
I have tried every way I can think of to change DA autoreceptor hyper-sensitivity and can still not quite get it right. I still believe I can, using the proper medications. One such would be sulpiride, a D2 antagonist which has antidepressant effects. Sulpiride will block D2 autoreceptors and postsynaptic receptors in the NAc and VTA, but importantly, also in the PFC, a property which haloperidol apparently does not possess.
I tried rexulti (it wasn't cheap since there is no generic). What happened was maybe 2 days of improvements and then reverted back to baseline. It was almost the same response as I would have expected from abilify after the long break, which makes sense since they are so similar.@hmnr asg did you ever trial low dose brexpiprazole (Rexulti)? Another way we could understand better what mechanism Abilify might have in ME is if people who tried other drugs of this class at low dose and we see similar effects.
Thanks for the details @hmnr asg. I can say from my experience I was taking moclobemide every day (MAO-A inhibitor antidepressant), and once or twice a week gabapentin, eszopiclone (sort of benzo), and melatonin during both my LDA trials where each time it improved ME symptoms tremendously for me for months and these other drugs didn’t seem to have a negative effect. Though I can’t tell you if without some or all of these other drugs if LDA would’ve worked longer.ps as always when sharing my experience I like to mention the other related meds im currently on: duloxetine 30mg/day, pregabalin 150mg/day, occasional benzos and melatonin. (Not sure what interactions it might have had with antipsychotics have but I had to mention in case someone finds it relevant).
I just checked my online pharmacy and they dont have the generic listed either.Btw brexpiprazole became generic in the US last year after court battles against Ostuka and Lundbeck, but funny even today when you look it up on GoodRx you can find it and the dosages but seems like no pharmacy carries it yet and no prices? Weird
I just checked my online pharmacy and they dont have the generic listed either.
What i did is to use the coupons on the manufacturer website to get a steep discount (I paid almost nothing). I think you can get 3 months worth of it for very little if you use the coupon, and since we are doing low dose and not the whole pill this will go a long way (if it works hopefully, which I doubt if abilify is not working).
Here is the link: https://www.rexulti.com/savings
do you know what dose of cariprazine they take? thank you