• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. Emeline

    Heat Insensitive Pain?

    When I’ve over done it and have pain, often in my back, if I lay on a heat pad, I can’t feel the heat, and when I apply biofreeze I can only feel the cool menthol sensation in odd spots that aren’t painful. This lack of heat sensitivity moves with the pain, but it’s not numbness- I can still...
  2. Apollonia

    Jones et al., 'Selective Inhibition of NaV1.8 with VX-548 for Acute Pain' NEJM 08.03.2023

    https://www.nejm.org/doi/full/10.1056/NEJMoa2209870 Summary of findings: https://www.drugs.com/news/researchers-explore-new-nonaddictive-means-fighting-pain-114170.html?hash2=23ebf82608bc6281f942e7b1cf323e06 Link to NEJM podcast (with transcription) including interview with Yale neurologist...
  3. C

    Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients (Thapaliya et al, 2023)

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID patients have overlapping neurological, autonomic, pain, and post-exertional symptoms. We compared volumes of brainstem regions for 10 ME/CFS (CCC or ICC criteria), 8 long COVID (WHO Delphi consensus), and 10...
  4. Phoenix Rising Articles

    Article When Pain is a Part of Your Crash: Insights From Research

    When Pain is a Part of Your Crash: Insights From Research For some people, pain is a significant component of their crashes. Image by vaxZine from Flickr, licensed CC BY-NC-ND 2.0. By Bronc Late last year Dr. Dane Cook, along with Dr. Jacob Lindheimer and colleagues, published a systematic...
  5. Pyrrhus

    Pain-related post-exertional malaise in ME/CFS and Fibromyalgia: A systematic review and three-level meta-analysis (Barhorst et al., 2021)

    Pain-related post-exertional malaise in ME/CFS and Fibromyalgia: A systematic review and three-level meta-analysis (Barhorst et al., 2021) https://doi.org/10.1093/pm/pnab308 Excerpt:
  6. nerd

    Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model

    Authors: Ji-Hye Song, Seul-Ki Won, Geun-Hyang Eom, Da-Som Lee, Byung-Jin Park, Jin-Seok Lee, Chang-Gue Son, Ji-Yeun Park Published on: September 22, 2021 pmid: 34638540 doi: 10.3390/ijms221910199 Abstract
  7. Apollonia

    New article on "Pain Reprocessing Therapy"

    https://archive.is/7LFNU There is a link in the article to the new research; it can be downloaded here: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2784694 Has anyone on PR received this kind of treatment?
  8. D

    HSV/VCV/CMV/HHV-6 - how to combine meds

    Dear guys and gals, my friend got her HHVs tested a month ago and she was IgM positive for HSV, VCV, CMV and HHV-6. Her symptoms are mainly chronic pain, but other than that she is "healthy" (the rest of her bloodwork is OK) so these infections are probably in the low-grade/chronic territory...
  9. frozenborderline

    Does pneumonia cause generalized muscle pains and spasms? Or PEM?

    I have this in hospital during cci surgery recovery and my ability to move is suddenly way worse, pain and muscle spasms way worse, they're being unclear about whether the pneumonia is totally the problem It could be worsened tethered cord. But the pneumonia and low grade fever could maybe...
  10. frozenborderline

    Solving the constipation side effects of opioids

    For context I shall put that i have no other options at this point than taking opioids for pain. I have exhausted most of the other issues. Also i dont think that my hemorrhoids and constipation are solely bc of opioids but i worded the title that way bc the opioids may have been last straw...
  11. frozenborderline

    I need help. Nyc/new Jersey area

    I'm sicker than ever. It's hard to explain all the things I need help with with how sick I am and how hard typing is becoming ironically. But some of it includes stuff a social worker would deal with ideally, or just stuff that is under purview of caregiving or doing tasks related to helping...
  12. nerd

    Letter: The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7

    Szpakowska, M., Decker, A.M., Meyrath, M. et al. The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7. Sig Transduct Target Ther 6, 209 (2021). doi: 10.1038/s41392-021-00548-w Authors: Martyna Szpakowska, Ann M. Decker, Max Meyrath, Christie B. Palmer...
  13. Tella

    Advice needed pls

    Hi I used to be severe and now am moderate. I believe recovery is possible but depends on many factors and it’s complex and wish each of u and myself only more improvement each day. I need advice please. Next week I have a 3 day meeting which I have to attend and I have to speak for half a day...
  14. frozenborderline

    "Copium for the masses--a podcast about the history, science and practicalities of growing natures best pain medication"

    I did a podcast about the history of opium, pain management , and practical side (how to grow and harvest your own opium ). I'm pretty sick so my friends had to so most of the editing but I still think it was informative.
  15. B

    Meet The Scientist – Professor Jo Nijs

    Jo Nijs is a Professor of Physiotherapy at the Vrije University of Brussels, Belgum and a manual therapist at the University Hospital Brussels. He is holder of the Chair, ‘Exercise Immunology and Chronic Fatigue in Health and Disease’ at the Vrije University of Brussels created by the research...
  16. frozenborderline

    Helpless (Essay i wrote from current place of pain and uncertainty)

  17. Jwarrior77

    Swollen Lymph Nodes Poll

    So since getting sick over a year ago I've developed swollen Lymph nodes in my neck. Now I know this is very common in ME/CFS. However most people I encounter have painful lymph nodes that come and go. Their lymph nodes are also usually enlarged on both sides of their neck. My swollen Lymph...
  18. nyanko_the_sane

    Connecting the Dots with EDS in Managing Pain w/Dr. Pradeep Chopra

    These Posts Have Been Moved from: https://forums.phoenixrising.me/threads/jen-brea-on-whether-some-of-us-might-be-mis-diagnosed-eds-patients.75684/page-2 Connecting the Dots with EDS in Managing Pain w/Dr. Pradeep Chopra Not sure how this great webinar got past us, but I am posting it here...
  19. gbells

    Do you have these bone pains with SEIDs?

    Please answer the following question if you have SEIDs.
  20. A

    Sudden onset of leg and tooth pain - advice needed

    Hey Guys and girls Ive had cfs/Me for the past 13 years. It started with EBV and my symptoms have been pretty constant the past decade. Namely lots of fatigue - needing to lay down most the day / finding it hard to sit up for too long, head pressure, POTS, achiness.... 6 weeks ago I got sore...