long covid

  1. K

    Internal tremor in Long COVID may be a symptom of dysautonomia and small fiber neuropathy, Blitshteyn et al., 2025

    https://www.mdpi.com/2035-8377/17/1/2 The article comprises a case study, patient perspective, and literature review. The patient in the case study experiences relief from internal tremor with ongoing fortnightly saline infusions. The tremor returns with overexertion and as the two weeks pass...
  2. SWAlexander

    A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals

    Introduction: Long COVID is a debilitating condition that lasts for more than three months post-infection by SARS–CoV–2. On average, one in ten individuals infected with SARS CoV- 2 develops Long COVID worldwide. A knowledge gap exists in our understanding of the mechanisms, genetic risk...
  3. Hip

    High-dose niacinamide fixed the mental and physical symptoms of a long COVID patient

    This Reddit post details how high-dose niacinamide (a form of vitamin B3) fixed the mental and physical symptoms of a long COVID patent His long COVID mental symptoms included depression, tearful emotional instability, and anger. His long COVID also included the symptoms of fatigue, brain fog...
  4. Hip

    Study finds brain-targeted autoimmunity plays key role in long COVID ME/CFS

    A new study finds long COVID ME/CFS is associated with autoantibodies directed at the following brain proteins: Myelin basic protein (MBP) Myelin oligodendrocyte glycoprotein (MOG) Tubulin Cerebellar protein-2 (CP2) Synapsin Myelin basic protein (MBP) plays a role in the formation and...
  5. Hip

    Bedbound long COVID ME/CFS patient becomes fit enough to play basketball after 6 weeks of rapamycin at 5 mg weekly

    This Reddit post details a long COVID ME/CFS patient who was bedbound and very ill for 2.5 years, becoming fit enough to play basketball with no PEM repercussions, after 6 weeks of rapamycin (sirolimus) at a dose of 5 mg once a week. He starting thinking in terms of trying rapamycin on the...
  6. F

    PolyBio - Long COVID low-dose rapamycin clinical trial

    Project Summary: A double blinded randomized controlled pilot clinical trial to determine if low-dose rapamycin can improve symptoms in patients with long COVID. The trial will be performed at the Cohn Center for Recovery from Complex Chronic Illness at Mount Sinai. Blood samples obtained from...
  7. SpinachHands

    Is hospitalisation an option? (UK)

    Haven't been here in a while so some background info- I care for my partner with long COVID/ME who has been fully bedbound since December. Their condition has only worsened with an onset of severe autonomic dysfunction in February. They are only able to have liquid food, cannot sit up, can't...
  8. FoxgloveFever

    HHV-6/EBV testing UK? / Remitting symptoms on Molnupiravir?

    Can anyone recommend a private UK clinic that offers testing and treatment for underlying EBV, HHV-6 etc infections? Has anyone else experienced a lessening of ME symptoms after taking Molnupiravir or any other Covid treatment? I've had ME since 2006, varying from mild to severe across the...
  9. TinaYesen

    Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection

    New study published April 17th, 2024. Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection Here's my immediate questions and serious concerns with this publication: Why did they only study patients with "mild to moderate" Long...
  10. G

    Researchers discover underlying cause of brain fog linked with long COVID

    Researchers discover underlying cause of brain fog linked with long COVID. Study Title: Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment (Nature Neuroscience) MedicalExpress.com: "The findings reported by the...
  11. SpinachHands

    Diagnosed with long COVID instead of ME- will this harm chances of treatment?

    My partner's appointment with the local NHS ME/CFS "specialist" clinic finally came around. (None of the doctors are actually ME specialists, just a team of physios, occupational therapists and dieticians.) I did the appointment on their behalf (with their consent) as they are too unwell. My...
  12. SWAlexander

    NIH to bolster RECOVER Long COVID research efforts through infusion of $515 million

    Excerpt: Four years after the COVID-19 pandemic began, Long COVID remains an unsolved, complex and urgent healthcare crisis. According to the Centers for Disease Control and Prevention, 1 in 9 adults in the United States who have ever had COVID-19 continue to experience Long COVID with a wide...
  13. L'engle

    Long Covid and brain scans

    An article that focuses on brain changes in Long Covid. Refers to several studies. It's a nice combination of personal case studies and discussion of research. https://www.statnews.com/2023/02/16/the-haunting-brain-science-of-long-covid/ I'm too exhausted to really add more. If it's...
  14. Cipher

    Impact of extended-course oral nirmatrelvir/ritonavir (Paxlovid) in established Long COVID: Case series and research considerations (Cohen et al.2023)

    Full-text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543503/ According to this table, 7 of the 13 patients in the case series experienced short-term improvements from an extended Paxlovid course, while 5 of the 13 patients experienced sustained improvements.
  15. O

    The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC

    The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC Objective To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment and function, and their relationship to demographic, clinical factors, post-acute...
  16. Hip

    Cognitive FX clinic say neurovascular coupling dysfunction causes ME/CFS; all very interesting, but they end up prescribing CBT and other nonsense!

    The Cognitive FX clinic in Utah has some interesting ideas about the possible cause of long COVID, but disappointingly, their treatment seems to involve the same old discredited cognitive behavioural therapy (CBT). Cognitive FX was founded in 2014 by Dr Allen and others in order to treat...
  17. Hip

    Several long COVID patients report improvements within days from antihistamines

    Several long COVID patients report substantial improvements within days from the first generation antihistamine diphenhydramine (Benadryl) 25 mg before bed. See: Benadryl seems to have helped me The “best” I feel is when I take diphenhydramine (Benadryl) Back to Benadryl cause it’s the only...
  18. junkcrap50

    Amsterdam scientists find an enzyme (IDO2) that could be the culprit of #LongCovid: Prolonged IDO2 activity & associated cellular stress in PASC.

    They found the IDO2 enzyme in "insane amounts" in Long Covid patients in all kinds of cells causing "a kind of collective suicide" as well as impaired mitochondrial function and Krebs Cycle dysfunction. They say it's clear that IDO2 continues to rage after the virus is defeated and IDO1...
  19. Hip

    Lots of long COVID patients reporting major improvements with lactoferrin

    A number of long COVID patients are reporting substantial improvements from the supplement lactoferrin. See these threads reporting major benefits (the brand and type used is indicated): Huge improvements with lactoferrin — Jan 2024 apolactoferrin Incredible recovery with lactoferrin! — Aug...
  20. Hip

    Pfizer's 7 hypotheses on the possible causes of long COVID

    Pfizer’s 7 Hypotheses on the Possible Causes of Long COVID Viral Persistence Studies have shown that, for some people, SARS-CoV-2 RNA may remain in the body well after the initial infection, resulting in the virus not being fully cleared and potentially causing chronic symptoms to persist...
  21. SWAlexander

    Effects of COVID-19 and vaccination on the human immune system: cases of lymphopenia and autoimmunity

    SARS-CoV-2 infection and the antigenic challenge induced by vaccinations against this pathogen elicit a diverse immunological response in humans. A variable immune response is expected during infection, but the ability of SARS-CoV-2 to evade host immunity and induce a deleterious effect on...
  22. Hip

    Metformin taken during acute COVID reduces risk of long COVID by 41%. ME/CFS often gets worse after COVID, so this drug may protect from such decline

    A study found that a two week course of metformin given within 3 days of testing positive for an acute COVID infection led to 41% fewer long covid diagnoses over the following 10 months compared with people who had taken placebo. For participants who started metformin less than 4 days after...
  23. X

    encouraging interview with immunologist Akiko Iwasaki

    This made my month. https://www.theguardian.com/society/2023/may/27/immunologist-akiko-iwasaki-we-are-not-done-with-covid-not-even-close For those of you too tired to read the whole thing: "I always have in the back of my mind – how can these insights from long Covid help people with ME/CFS...
  24. SWAlexander

    **EXCLUSIVE** Biomarker Breakthrough?

    Listen to Bhupesh Prusty interview in the link. https://www.tlcsessions.net/episodes/episode-58-breakthrough-biomarker- For the past three years we have suffered with a myriad of over 200 symptoms. Every expert that we have spoken to has either treated the symptoms whilst acknowledging the...
  25. Hip

    Long COVID "brain numbness" versus ME/CFS brain fog

    Since catching COVID just over a year ago and developing some long COVID on top of existing ME/CFS, I've found that whilst ME/CFS gives me brain fog, long COVID for me seems to produce what you might call "brain numbness". This brain numbness feels like having your brain mildly anaesthetised: I...
  26. O

    Endothelial dysfunction in Long-Covid measured by RVA correlates with symptom severity and inflammation

    Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vmax; 3.42% ± 1.77% vs. 4.64 % ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5 - 190.2] vs. 189.1...
  27. P

    What happened to covid? and the research into long covid... 2023 feels different

    Doesn't 2023 feel wholly different with respect to covid? While the country was obsessed with this virus for almost 3 years, especially that first year with lockdowns and 24/7 news coverage, etc, 2023 just has a very different feel. On some days I even forget about it. Offices are calling us...
  28. Hip

    Long COVID ME/CFS patient goes into remission after 3 weeks on the antiviral sofosbuvir

    A long COVID patient on Reddit (Warm_Camera_7052) with ME/CFS symptoms reports that after he took the antiviral sofosbuvir for just 3 weeks, this put his illness into full remission. He has only been in remission for one month though, so relapse remains a possibility. His brother with LC...
  29. C

    Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes (Reese et al, 2022)

    Summary Background Stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, long COVID is incompletely understood and characterised by a wide range of manifestations that are difficult to...
  30. SWAlexander

    The Draft Report by the Institute for Quality and Efficiency in Healthcare Does Not Provide Any Evidence That Graded Exercise Therapy and Cognitive Be

    Abstract The German Institute for Quality and Efficiency in Healthcare (IQWiG) recently published its draft report to the government about myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The IQWiG concluded that graded exercise therapy (GET) and cognitive behavioral therapy (CBT)...
Back