long covid

Introduction: Long COVID is a debilitating condition that lasts for more than three months post-infection by SARS–CoV–2. On average, one in ten individuals infected with SARS CoV- 2 develops Long COVID worldwide. A knowledge gap exists in our understanding of the mechanisms, genetic risk...

This Reddit post details how high-dose niacinamide (a form of vitamin B3) fixed the mental and physical symptoms of a long COVID patent His long COVID mental symptoms included depression, tearful emotional instability, and anger. His long COVID also included the symptoms of fatigue, brain fog...

A new study finds long COVID ME/CFS is associated with autoantibodies directed at the following brain proteins: Myelin basic protein (MBP) Myelin oligodendrocyte glycoprotein (MOG) Tubulin Cerebellar protein-2 (CP2) Synapsin Myelin basic protein (MBP) plays a role in the formation and...

This Reddit post details a long COVID ME/CFS patient who was bedbound and very ill for 2.5 years, becoming fit enough to play basketball with no PEM repercussions, after 6 weeks of rapamycin (sirolimus) at a dose of 5 mg once a week. He starting thinking in terms of trying rapamycin on the...

Project Summary: A double blinded randomized controlled pilot clinical trial to determine if low-dose rapamycin can improve symptoms in patients with long COVID. The trial will be performed at the Cohn Center for Recovery from Complex Chronic Illness at Mount Sinai. Blood samples obtained from...

Haven't been here in a while so some background info- I care for my partner with long COVID/ME who has been fully bedbound since December. Their condition has only worsened with an onset of severe autonomic dysfunction in February. They are only able to have liquid food, cannot sit up, can't...

Can anyone recommend a private UK clinic that offers testing and treatment for underlying EBV, HHV-6 etc infections? Has anyone else experienced a lessening of ME symptoms after taking Molnupiravir or any other Covid treatment? I've had ME since 2006, varying from mild to severe across the...

New study published April 17th, 2024. Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection Here's my immediate questions and serious concerns with this publication: Why did they only study patients with "mild to moderate" Long...

Researchers discover underlying cause of brain fog linked with long COVID. Study Title: Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment (Nature Neuroscience) MedicalExpress.com: "The findings reported by the...

My partner's appointment with the local NHS ME/CFS "specialist" clinic finally came around. (None of the doctors are actually ME specialists, just a team of physios, occupational therapists and dieticians.) I did the appointment on their behalf (with their consent) as they are too unwell. My...

Excerpt: Four years after the COVID-19 pandemic began, Long COVID remains an unsolved, complex and urgent healthcare crisis. According to the Centers for Disease Control and Prevention, 1 in 9 adults in the United States who have ever had COVID-19 continue to experience Long COVID with a wide...

An article that focuses on brain changes in Long Covid. Refers to several studies. It's a nice combination of personal case studies and discussion of research. https://www.statnews.com/2023/02/16/the-haunting-brain-science-of-long-covid/ I'm too exhausted to really add more. If it's...

Full-text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543503/ According to this table, 7 of the 13 patients in the case series experienced short-term improvements from an extended Paxlovid course, while 5 of the 13 patients experienced sustained improvements.

The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC Objective To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment and function, and their relationship to demographic, clinical factors, post-acute...

The Cognitive FX clinic in Utah has some interesting ideas about the possible cause of long COVID, but disappointingly, their treatment seems to involve the same old discredited cognitive behavioural therapy (CBT). Cognitive FX was founded in 2014 by Dr Allen and others in order to treat...

Several long COVID patients report substantial improvements within days from the first generation antihistamine diphenhydramine (Benadryl) 25 mg before bed. See: Benadryl seems to have helped me The “best” I feel is when I take diphenhydramine (Benadryl) Back to Benadryl cause it’s the only...

They found the IDO2 enzyme in "insane amounts" in Long Covid patients in all kinds of cells causing "a kind of collective suicide" as well as impaired mitochondrial function and Krebs Cycle dysfunction. They say it's clear that IDO2 continues to rage after the virus is defeated and IDO1...

A number of long COVID patients are reporting substantial improvements from the supplement lactoferrin. See these threads reporting major benefits (the brand and type used is indicated): Huge improvements with lactoferrin — Jan 2024 apolactoferrin Incredible recovery with lactoferrin! — Aug...

Pfizer’s 7 Hypotheses on the Possible Causes of Long COVID Viral Persistence Studies have shown that, for some people, SARS-CoV-2 RNA may remain in the body well after the initial infection, resulting in the virus not being fully cleared and potentially causing chronic symptoms to persist...

SARS-CoV-2 infection and the antigenic challenge induced by vaccinations against this pathogen elicit a diverse immunological response in humans. A variable immune response is expected during infection, but the ability of SARS-CoV-2 to evade host immunity and induce a deleterious effect on...

A study found that a two week course of metformin given within 3 days of testing positive for an acute COVID infection led to 41% fewer long covid diagnoses over the following 10 months compared with people who had taken placebo. For participants who started metformin less than 4 days after...

This made my month. https://www.theguardian.com/society/2023/may/27/immunologist-akiko-iwasaki-we-are-not-done-with-covid-not-even-close For those of you too tired to read the whole thing: "I always have in the back of my mind – how can these insights from long Covid help people with ME/CFS...

Listen to Bhupesh Prusty interview in the link. https://www.tlcsessions.net/episodes/episode-58-breakthrough-biomarker- For the past three years we have suffered with a myriad of over 200 symptoms. Every expert that we have spoken to has either treated the symptoms whilst acknowledging the...

Since catching COVID just over a year ago and developing some long COVID on top of existing ME/CFS, I've found that whilst ME/CFS gives me brain fog, long COVID for me seems to produce what you might call "brain numbness". This brain numbness feels like having your brain mildly anaesthetised: I...

Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vmax; 3.42% ± 1.77% vs. 4.64 % ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5 - 190.2] vs. 189.1...

Doesn't 2023 feel wholly different with respect to covid? While the country was obsessed with this virus for almost 3 years, especially that first year with lockdowns and 24/7 news coverage, etc, 2023 just has a very different feel. On some days I even forget about it. Offices are calling us...

A long COVID patient on Reddit (Warm_Camera_7052) with ME/CFS symptoms reports that after he took the antiviral sofosbuvir for just 3 weeks, this put his illness into full remission. He has only been in remission for one month though, so relapse remains a possibility. His brother with LC...

Summary Background Stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, long COVID is incompletely understood and characterised by a wide range of manifestations that are difficult to...

Abstract The German Institute for Quality and Efficiency in Healthcare (IQWiG) recently published its draft report to the government about myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The IQWiG concluded that graded exercise therapy (GET) and cognitive behavioral therapy (CBT)...

It is a very extensive study. Abstract Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million...