Endothelial dysfunction in Long-Covid measured by RVA correlates with symptom severity and inflammation


Senior Member
Measurements and main results

PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vmax; 3.42% ± 1.77% vs. 4.64 % ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5 - 190.2] vs. 189.1 [179.4 - 197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8 - 0.9] vs. 0.88 [0.8 - 0.9], p = 0.007). When combining AVR and vmax, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R= -0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters.

The study:

Study registration:

Finally a study using advanced measurement techniques. If we now add OCT-A to this and NIRS and other precise and advanced techniques that can determine oxygenation and damage in small tissue and vessels in PCS & ME/CFS we can actually finally get somewhere. On clinicaltrials.gov it says that they will also use OCT-A and hand grip strength test, so I'm expecting more work from this group in the near future.