autoimmunity

A new study finds long COVID ME/CFS is associated with autoantibodies directed at the following brain proteins: Myelin basic protein (MBP) Myelin oligodendrocyte glycoprotein (MOG) Tubulin Cerebellar protein-2 (CP2) Synapsin Myelin basic protein (MBP) plays a role in the formation and...

If you have the time and stamina, I highly recommend watching Dr. Galland on YouTube, where he extensively explains how COVID-19 damages organs and tissues, and how ME/CFS differs from it. Long Covid Mechanisms, Spike Protein, Detox, Nattokinase, MCAS, POTS, Autoimmunity, ACE2, Dr Galland

It is a very extensive study. Abstract Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million...

A study has analysed existing genetic data in a new way to link 14 genes to ME/CFS and identify many patient subgroups. If the new approach pans out, it could transform ME research and turbocharge the development of treatments. Paper: Genetic Risk Factors for ME/CFS Identified Using...

Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical, psychological, cognitive, social, and occupational functions. The cause of ME/CFS remains incompletely understood. There is no clinical...

Abstract Abstract: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is considered to be associated with post-viral complications and mental stress, but the role of autoimmunity also remains promising. A comparison of autoimmune profiles in chronic fatigue of different origin may...

Autoimmunity Research in ME/CFS I thought I would start a thread summarizing the research publications related to auto-immunity in ME. Please feel free to add new publications as appropriate. I'll start with Carmen Scheibenbogen's work. Here is the 2015 paper by Carmen Scheibenbogen that...

The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity (Lodha et al., 2022) https://doi.org/10.3389/fmicb.2022.840911 An article from Bhupesh Prusty about cryptic antigens, which are one way that viruses can cause auto-immunity. To learn more about cryptic antigens...

:monocle: I thought I would start a thread to summarize discussions about the research on how viruses can cause autoimmunity. :monocle: We already have two good discussions about papers which describe the ways in which viral infections, or chronic inflammation, can cause autoimmunity: How...

This is a really interesting article from the Journal "Nature" called, "How pandemics strengthen links between viruses and autoimmunity". Here is the link: https://www.nature.com/articles/d41586-021-01835-w The article is a little bit long but was super interesting (at least to me :nerd:)...

https://pubmed.ncbi.nlm.nih.gov/34254637/ Hypothalamic-Pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome Annamaria De Bellis, 1, 2, Giuseppe Bellastella, 2, 3, Vlenia Pernice, 2, Paolo Cirillo, 2, Miriam Longo, 2, 3...

31 of 364 ME/CFS patients tested positive for at least 1 of 4 autoantibodies in this study for small-fiber polyneuropathy. Those 31 patients have pretty much identified the cause of their fatigue. So you think, "well that's less than 10%, so I'm not likely part of that group". Wrong. You...

https://www.mdpi.com/2077-0383/9/8/2443/htm Abstract (1) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex neuroimmunological disease. There is evidence for an autoimmune mechanism for ME/CFS with an infection-triggered onset and dysfunction of ß2-adrenoreceptor...

Sorry for the cumbersome title, but the following study is definitely worth looking at. I love it because it reflects my idea that an external trigger, i.e. an entity with different DNA (or RNA) from your own triggers ME. Many of us got ME after having a "run of the mill" viral infection. I...

Brain, Behavior, & Immunity - Health Available online 5 February 2020, 100047 IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS Author links open overlay...

Clin Ther. 2019 Apr 30. pii: S0149-2918(19)30163-8. doi: 10.1016/j.clinthera.2019.04.001. [Epub ahead of print] Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome. Giannoccaro MP1, Cossins J2, Sørland K3, Fluge Ø3, Vincent A2...

Is it possible to have auto immunity issues with negative ANA and not that high CRP?

I have to tell my (family) doctor tommorrow about the autoantibodies I tested positive for. (Adrenergic, muscarinic ACh and angiotensin) At the same time I have negative ANAs (1:80) and I worry that my doctor will think that there can‘t be a problem because of the negative ANAs. (That is what a...

PLoS One. 2018 Mar 15;13(3):e0193672. doi: 10.1371/journal.pone.0193672. eCollection 2018. Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME. Scheibenbogen C1,2, Loebel M1, Freitag H1, Krueger A3, Bauer S1, Antelmann M1, Doehner W4, Scherbakov N4...

Posting this in the hopes that it helps someone better determine an autoimmune etiology and move down an appropriate path of treatment (e.g. anti-inflammatories / immunomodulators / immunosuppressants). At very least these labs may point to a verifiable disease process when other labs are...

Antibodies to adrenergic and muscarinic receptors in ME/CFS Paolo Maccalliniin agosto 29, 2017 1,396 Words https://paolomaccallini.wordpress.com/2017/08/29/antibodies-to-adrenergic-and-muscarinic-receptors-in-mecfs/

Antiadrenergic autoimmunity in postural tachycardia syndrome Artur Fedorowski1,2,*,†, Hongliang Li3, Xichun Yu3, Kristi A. Koelsch3,4, Valerie M. Harris3,4, Campbell Liles3, Taylor A. Murphy3, Syed M.S. Quadri3,4, Robert Hal Scofield3,4, Richard Sutton5, Olle Melander1 and David C. Kem3,† 1...

Loebel, Grabowski, Heidecke, Bauer, Hanitsch, Wittke, Meisel, Reinke, Volk, Fluge Ø, Mella, Scheibenbogen. Abstract Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors...

ABSTRACT Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the development of autoimmune diseases. In this...