I've been on here for quite some time, following a modified version of Freddd's protocol for the past few years. At first, it brought me a ton of relief, and it felt like nothing I'd ever felt before. I'm here to tell you, before you take this path, you may wish to consider your options before taking things into your own hands. I'm not doubting that the information here has helped many people, nor am I doubting the caring mindset and devotion that everyone has put forward. It just may or may not be for you, and there may be some consequences. For close to 2 years, I was on more or less 6mg of methylfolate every day, 5mg of methyl B12, L-carnitine, and at times, 18mg of FMN (B2). Let me tell you, having an MAOA mutation as well, it felt GREAT. It was like being on amphetamines, without the side effects, 24/7. Of course, a tolerance seemed to develop. Along with anxiety, irritability, and other things. I took a break. During my 2 month break, I was extremely depressed, tired, dysfunctional, and really just not going anywhere. So I ended it and got back to trying new combinations, eventually reaching 10mg of methylfolate, and feeling like superman. For a month or two, then it wasn't enough, yet I was even more irritable. I couldn't crack the puzzle. It was like I was getting somewhere, more energy, feeling more alive, and more able to do things, yet I was driving people away, making poorer choices, and in some ways, feeling worse. Not to mention planning my life around my supplements. Going on a date? Pop an extra 2mg of methylfolate. Shit, took too much, now I'm off the wall (but hypersexual, sweet!). Fast forward to summer this year. My doctor during an average appointment yelled at me for not seeing a sleep specialist with the issues I was having. She said she wouldn't see me again until I did. Well, one 18 hour sleep study (PSG & MSLT) later, and another sleep specialist (the first guy just wanted to give me provigil for the rest of my life), and a few months of fighting my insurance later, I'm back with a narcolepsy diagnosis, taking Xyrem every night and feeling the best I've ever felt. Except for one thing. I've been mostly off the B vitamins for a while, only taking them here and there. But a lot of aspects of my life are still off. If I don't take B vitamins for a while, I start getting depressed, slow, and just generally down. It's almost like withdrawal, and feels not unlike when I came off of 3 years of adderall 10 years ago (okay, way milder, but similar). I took a B complex the past few days for the first time in a while and low and behold, I'm over talking, anxious, a little irritable, and full of energy. Wasn't worth it. So my message here is to consider if you want to take this path. I still doubt doctors like crazy, but I've found some way better ones in my new home (NYC) than I ever had in the sticks, and they're actually in touch with things. You may have something else in fact, or you may not. But if nothing else, I encourage you to do one thing if you're on a regimen right now. When I did my sleep studies, I had to stop all supplements. It was then that I (and my friends around me) realized that maybe they weren't for me. I encourage you to try a week or two off and see how you feel. You might be surprised. Hope this helps someone else out there! Cheers.