picante
Senior Member
- Messages
- 829
- Location
- Helena, MT USA
I have a bunch of puzzle pieces I'd like to spread out on the table and see if the mighty group brain can put them together for me. I have lots of data, but no idea what tests I should have done next or new remedies I might reasonably try.
The most recent discovery in the saga of my treatment is recorded here for posterity:
http://forums.phoenixrising.me/inde...arguments-confuse-me.21963/page-5#post-625201
Briefly, that is where I ditched reduced L-glutathione cream because I realized that it was provoking glutamate toxicity (and other problems). Thank you, @Freddd.
Since starting methylation supps a year ago, I've been experiencing severe problems with thiol-containing foods, and now I've found another co-traveler: http://forums.phoenixrising.me/inde...lfur-pst-and-sulfate-reducing-bacteria.39415/
@Changexpert and I have different symptoms, but for both of us, the sensitivity came on when we started trying methylation protocols. For me, it marked the return of the digestive problems I had before I started taking T3 for Hashimoto's thyroiditis. T3 controlled this for 6-7 years; it returned with my attempts at methylation.
Before that, I could eat eggs (as many as I wanted), chard, organic cheese, animal protein, and many other things that now knock me down for the count at very low threshholds. We are both in a blind alley with MeB12 and AdB12: for me, all it takes is one drop of liquid MeB12 applied on my skin (approx. 66 mcg) two days in a row. That triggers not being able to eat much of anything.
Strangely, that first day on one drop of MeB12 (AdB12) my cellular thyroid metabolism goes up and I feel better. A few hours after the 2nd day's dose, everything goes to hell.
The symptoms are the same set I have from ingesting glutamates such as autolyzed yeast extract, which I avoid like the plague: immediate helium-balloon bloatation, and I get intensely groggy (Zzzzzzz, I'm in the poppy field in Oz). The tiny doses of B12s aggravate this, and trigger insatiable potassium deficiency. Shoveling in the potassium then triggers B1 and zinc deficiencies, and I have to go off protein and B12s/mfolate to let all this sort itself out.
No, I don't have any +/+ CBS snps. The problems lie elsewhere. Given the +/+ snps I do have, I may be having trouble converting homocysteine to methionine (both pathways). And I suspect problems with conversion of glutamate-to-glutathione and glutamate-to-GABA (based on symptoms). I also suspect problems with sulfite-sulfate conversion.
Other clues I've been putting together:
Sulfite inhibits Glutamate Dehydrogenase: http://www.ncbi.nlm.nih.gov/pubmed/15273247
Glutamate & Thyroid: http://www.ncbi.nlm.nih.gov/pubmed/18543341 T(3) regulates extracellular glutamate levels by modulating the astrocytic glutamate transporters.
γ-Aminobutyric acid production by culturable bacteria from the human intestine
http://www.ncbi.nlm.nih.gov/pubmed/22612585
@Gondwanaland steered me here, so I'm trying a probiotic with Lactobacillus brevis in it now.
The most recent discovery in the saga of my treatment is recorded here for posterity:
http://forums.phoenixrising.me/inde...arguments-confuse-me.21963/page-5#post-625201
Briefly, that is where I ditched reduced L-glutathione cream because I realized that it was provoking glutamate toxicity (and other problems). Thank you, @Freddd.
Since starting methylation supps a year ago, I've been experiencing severe problems with thiol-containing foods, and now I've found another co-traveler: http://forums.phoenixrising.me/inde...lfur-pst-and-sulfate-reducing-bacteria.39415/
@Changexpert and I have different symptoms, but for both of us, the sensitivity came on when we started trying methylation protocols. For me, it marked the return of the digestive problems I had before I started taking T3 for Hashimoto's thyroiditis. T3 controlled this for 6-7 years; it returned with my attempts at methylation.
Before that, I could eat eggs (as many as I wanted), chard, organic cheese, animal protein, and many other things that now knock me down for the count at very low threshholds. We are both in a blind alley with MeB12 and AdB12: for me, all it takes is one drop of liquid MeB12 applied on my skin (approx. 66 mcg) two days in a row. That triggers not being able to eat much of anything.
Strangely, that first day on one drop of MeB12 (AdB12) my cellular thyroid metabolism goes up and I feel better. A few hours after the 2nd day's dose, everything goes to hell.
The symptoms are the same set I have from ingesting glutamates such as autolyzed yeast extract, which I avoid like the plague: immediate helium-balloon bloatation, and I get intensely groggy (Zzzzzzz, I'm in the poppy field in Oz). The tiny doses of B12s aggravate this, and trigger insatiable potassium deficiency. Shoveling in the potassium then triggers B1 and zinc deficiencies, and I have to go off protein and B12s/mfolate to let all this sort itself out.
No, I don't have any +/+ CBS snps. The problems lie elsewhere. Given the +/+ snps I do have, I may be having trouble converting homocysteine to methionine (both pathways). And I suspect problems with conversion of glutamate-to-glutathione and glutamate-to-GABA (based on symptoms). I also suspect problems with sulfite-sulfate conversion.
Other clues I've been putting together:
Sulfite inhibits Glutamate Dehydrogenase: http://www.ncbi.nlm.nih.gov/pubmed/15273247
Glutamate & Thyroid: http://www.ncbi.nlm.nih.gov/pubmed/18543341 T(3) regulates extracellular glutamate levels by modulating the astrocytic glutamate transporters.
γ-Aminobutyric acid production by culturable bacteria from the human intestine
http://www.ncbi.nlm.nih.gov/pubmed/22612585
@Gondwanaland steered me here, so I'm trying a probiotic with Lactobacillus brevis in it now.