If one is deficient in sulfate, but have a lot of sulfate reducing bacteria due to gut dysbiosis, what is the way out of this catch 22? Also, is taking sulfur or foods rich in sulfur same as taking sulfate? Ever since I was on methylation protocol last year, my sulfur sensitivity heightened and never became normal again. Now, I can't even tolerate 75 mcg of biotin compared to 15,000 mcg I used to take. Similar reactions to B1 and methionine, which has sulfur. I am finding ALA chelation quite helpful, but not good enough. Besides avoiding high thiol foods, what are some options I have? I am almost sure that I am low in PST enzymes, which would explain why I react so negatively to B6. B6 inhibits PST activity, which worsens phenol metabolism. What are the ways to strengthen this pathway? I am speculating that most supplements that strengthens liver function would be helpful, but I cannot take most of them due to other conditions I have. Liver supplements that I react badly to Mlik thistle (high salicylate) GliSODin (sulfur) Calcium D glucarate (not sure why) Glycine (oxalate issue possibly) Proline (same as glycine) B vitamins NAC (thiol) Taurine (sulfur? not sure why) Glutamine (problematic at high dose, excitotoxicity) Cruciferous veggies (thiol) I think there is a connection among sulfate, SRBs, PST, and sulfur for sure, but I don't know what that is exactly. Also, what would be the best protocol to tackle this? Your insight would be greatly appreciated.