im starting high dose thiamine this week and i want to make sure i do it right. i haven’t really seen a good playbook on cofactors needed, dosing, safety, and what not?
am i supposed to supplement magnesium? anything else? other b vitamins?
is it generally safe, even at doses upwards of 1,800mg? my pharmacist says he can only find it’s safe at 500 mg.
any medication interactions to be aware of? i’m on ldn, abilify, mestinon, metoprolol, sometimes use celebrex
anything else i need to know? thanks!!
I always Google "drugname nutrients depleted" to figure out what I need to watch for. And, because I take several medications, I do a comprehensive nutrient test once a year to correct for any imbalances.
You are correct that you could end up with imbalances taking a mega dose of something and cause a cascade of problems.
Nutrients get used in one or more pathways that have other ingredients, called cofactors. If you al of a sudden dump in a huge amount of one of these, you'll use up the other ones pretty fast and then get stuck because you ran out of the others.
I've been on a balanced program of B vitamins, including 750mg benfotiamine, s form of B1. I kept reading, especially from the Hormones Matter/Derrick Lonsdale/Elliott Overton crowd, how benfotiamine doesn't go through the blood brain barrier and only allithiamine would do. (I don't think this is true at all as I have no brain symptoms.)
But, I thought I'd give it a try. After repeatedly asking that crowd for dosing info and getting nowhere with them telling me anything useful, I decided to start conservatively at 300mg of Thiamax.
I ended up with neuropathy (tingling) in my hands and feet within a week. This is not good and a sign that mitochondria are being damaged. It took me about 3 weeks to realize this was an ongoing problem and retrace my steps to figure out that's what did it.
I stopped it for 3 days, then gradually went back to benfotiamine, starting at 250mg, then 500mg, then 750mg over 3 weeks.
My neuropathy started to resolve and went away completely.
This stuff isn't candy, and more is not better. Thiamine deficiency is very real, and there are amazing stories of recovery after taking some from deficient people, but taking enormous doses can backfire fast. And I know my 750mg dose is very high already, but I'm taking all the cofactors in a balanced amount, including molybdenum.
It might be prudent to learn more about B vitamins and your own nutrient status before embarking on a mega dose protocol.