I often see ME/CFS patients that undergo exercise tests to be diagnosed with two problems: orthostatic intolerance (preload failure) and impaired oxygen extraction (mitochondrial dysfunction).
They seem to be pretty well connected, but I've never seen anyone explaining which one is driving the other, and what is their relationship. Could someone please point me to some studies that explain this?
They seem to be pretty well connected, but I've never seen anyone explaining which one is driving the other, and what is their relationship. Could someone please point me to some studies that explain this?