• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

weakness of the collagen surrounding peripheral nerves in Ehlers-Danlos Syndrome (EDS)


Senior Member
@Hip maybe we should get a special attention at the collagen tissus surrounding the nervous system…(not only the ligaments and dura)


Neurological and spinal manifestations of the Ehlers–Danlos syndromes

Fraser C. Henderson Sr.
Claudiu Austin
Edward Benzel
Paolo Bolognese

21 February 2017


The Ehlers–Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility.
This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves.
Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression.
This report also discusses increased prevalence of migraine, idiopathic intracranial hypertension, Tarlov cysts, tethered cord syndrome, and dystonia, where associations with EDS have been anecdotally reported, but where epidemiological evidence is not yet available. Chiari Malformation Type I (CMI) has been reported to be a comorbid condition to EDS, and may be complicated by craniocervical instability or basilar invagination. Motor delay, headache, and quadriparesis have been attributed to ligamentous laxity and instability at the atlanto‐occipital and atlantoaxial joints, which may complicate all forms of EDS. Discopathy and early degenerative spondylotic disease manifest by spinal segmental instability and kyphosis, rendering EDS patients prone to mechanical pain, and myelopathy. Musculoskeletal pain starts early, is chronic and debilitating, and the neuromuscular disease of EDS manifests symptomatically with weakness, myalgia, easy fatigability, limited walking, reduction of vibration sense, and mild impairment of mobility and daily activities. Consensus criteria and clinical practice guidelines, based upon stronger epidemiological and pathophysiological evidence, are needed to refine diagnosis and treatment of the various neurological and spinal manifestations of EDS.


Senior Member
U.S., Earth
the weakness of the epineurium and perineurium surrounding peripheral nerves.

Note that the epineurium and perineurium are both made of collagen to protect peripheral nerves:
On the outside of each peripheral nerve, there is collagenous tissue: epineurium. Surrounding every fascicle within the nerve is the perineurium. Individual nerve fibers within the fascicles are embedded in endoneurium, which fills the space bound by the perineurium.
Source: https://www.nysora.com/foundations-...anatomy/connective-tissues-peripheral-nerves/