Volumetric differences in hippocampal subfields and associations with clinical measures in ME/CFS (Thapaliya et al., 2022)
https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.25048
From the team of Dr. Kiran Thapaliya, Leighton Barnden, Donald Staines, and Sonya Marshall-Gradisnik.
The authors described the finding on Facebook:
Abstract:
(spacing added for readability)
https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.25048
From the team of Dr. Kiran Thapaliya, Leighton Barnden, Donald Staines, and Sonya Marshall-Gradisnik.
The authors described the finding on Facebook:
๐ง๐ต๐ฒ ๐ธ๐ฒ๐ ๐ณ๐ถ๐ป๐ฑ๐ถ๐ป๐ด๐ ๐ณ๐ฟ๐ผ๐บ ๐๐ต๐ถ๐ ๐๐๐๐ฑ๐ ๐ฎ๐ฟ๐ฒ:
- Our study found left hippocampal: subiculum, pre-subiculum and fimbria volumes were ๐จ๐๐๐ฃ๐๐๐๐๐๐ฃ๐ฉ๐ก๐ฎ ๐ก๐๐ง๐๐๐ง ๐๐ฃ ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐ ๐๐ช๐ฉ ๐ฃ๐ค๐ฉ ๐๐ค๐ง ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐ช๐ ๐ช๐๐ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Hippocampal subfield volumes were ๐จ๐ฉ๐ง๐ค๐ฃ๐๐ก๐ฎ ๐๐จ๐จ๐ค๐๐๐๐ฉ๐๐ with clinical measures (fatigue, sleep disturbance, physical activity, pain and information processing) in ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐, whereas ๐ข๐ค๐๐๐ง๐๐ฉ๐ ๐๐จ๐จ๐ค๐๐๐๐ฉ๐๐ค๐ฃ๐จ were observed in ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐ช๐ ๐ช๐๐ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Clinical measures related to ๐๐ค๐๐ฃ๐๐ฉ๐๐ซ๐ ๐๐ช๐ฃ๐๐ฉ๐๐ค๐ฃ, ๐ฅ๐๐๐ฃ ๐๐ฃ๐ ๐ฅ๐๐ฎ๐จ๐๐๐๐ก ๐๐๐ฉ๐๐ซ๐๐ฉ๐ฎ showed a ๐จ๐ฉ๐ง๐ค๐ฃ๐ ๐ง๐๐ก๐๐ฉ๐๐ค๐ฃ๐จ๐๐๐ฅ with hippocampal subfield volumes in the ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐.
- We showed that ๐๐๐๐๐๐ง ๐ฅ๐๐๐ฃ ๐๐ฃ๐ ๐๐๐ฉ๐๐๐ช๐ ๐ก๐๐ซ๐๐ก๐จ were associated with ๐จ๐ข๐๐ก๐ก๐๐ง ๐๐๐ฅ๐ฅ๐ค๐๐๐ข๐ฅ๐๐ก ๐จ๐ช๐๐๐๐๐ก๐ ๐ซ๐ค๐ก๐ช๐ข๐๐จ. Furthermore, ๐ข๐ค๐ง๐ ๐จ๐๐ซ๐๐ง๐ ๐จ๐ก๐๐๐ฅ ๐๐๐จ๐ฉ๐ช๐ง๐๐๐ฃ๐๐ ๐๐ฃ๐ ๐ฅ๐ค๐ค๐ง๐๐ง ๐๐ฃ๐๐ค๐ง๐ข๐๐ฉ๐๐ค๐ฃ ๐ฅ๐ง๐ค๐๐๐จ๐จ๐๐ฃ๐ ๐จ๐๐ค๐ง๐๐จ were also associated with ๐ก๐๐ง๐๐๐ง ๐จ๐ช๐๐๐๐๐ก๐ ๐ซ๐ค๐ก๐ช๐ข๐๐จ ๐๐ฃ ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Therefore, our study demonstrated that ๐จ๐ฉ๐ง๐๐๐ฉ ๐๐๐จ๐ ๐๐๐๐๐ฃ๐๐ฉ๐๐ค๐ฃ๐จ ๐๐ง๐ ๐๐จ๐จ๐๐ฃ๐ฉ๐๐๐ก in the investigation of the ๐ฅ๐๐ฉ๐๐ค๐ฅ๐๐ฎ๐จ๐๐ค๐ก๐ค๐๐ฎ ๐ค๐ ๐๐/๐พ๐๐.
- Our study found left hippocampal: subiculum, pre-subiculum and fimbria volumes were ๐จ๐๐๐ฃ๐๐๐๐๐๐ฃ๐ฉ๐ก๐ฎ ๐ก๐๐ง๐๐๐ง ๐๐ฃ ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐ ๐๐ช๐ฉ ๐ฃ๐ค๐ฉ ๐๐ค๐ง ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐ช๐ ๐ช๐๐ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Hippocampal subfield volumes were ๐จ๐ฉ๐ง๐ค๐ฃ๐๐ก๐ฎ ๐๐จ๐จ๐ค๐๐๐๐ฉ๐๐ with clinical measures (fatigue, sleep disturbance, physical activity, pain and information processing) in ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐, whereas ๐ข๐ค๐๐๐ง๐๐ฉ๐ ๐๐จ๐จ๐ค๐๐๐๐ฉ๐๐ค๐ฃ๐จ were observed in ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐๐ช๐ ๐ช๐๐ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Clinical measures related to ๐๐ค๐๐ฃ๐๐ฉ๐๐ซ๐ ๐๐ช๐ฃ๐๐ฉ๐๐ค๐ฃ, ๐ฅ๐๐๐ฃ ๐๐ฃ๐ ๐ฅ๐๐ฎ๐จ๐๐๐๐ก ๐๐๐ฉ๐๐ซ๐๐ฉ๐ฎ showed a ๐จ๐ฉ๐ง๐ค๐ฃ๐ ๐ง๐๐ก๐๐ฉ๐๐ค๐ฃ๐จ๐๐๐ฅ with hippocampal subfield volumes in the ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐.
- We showed that ๐๐๐๐๐๐ง ๐ฅ๐๐๐ฃ ๐๐ฃ๐ ๐๐๐ฉ๐๐๐ช๐ ๐ก๐๐ซ๐๐ก๐จ were associated with ๐จ๐ข๐๐ก๐ก๐๐ง ๐๐๐ฅ๐ฅ๐ค๐๐๐ข๐ฅ๐๐ก ๐จ๐ช๐๐๐๐๐ก๐ ๐ซ๐ค๐ก๐ช๐ข๐๐จ. Furthermore, ๐ข๐ค๐ง๐ ๐จ๐๐ซ๐๐ง๐ ๐จ๐ก๐๐๐ฅ ๐๐๐จ๐ฉ๐ช๐ง๐๐๐ฃ๐๐ ๐๐ฃ๐ ๐ฅ๐ค๐ค๐ง๐๐ง ๐๐ฃ๐๐ค๐ง๐ข๐๐ฉ๐๐ค๐ฃ ๐ฅ๐ง๐ค๐๐๐จ๐จ๐๐ฃ๐ ๐จ๐๐ค๐ง๐๐จ were also associated with ๐ก๐๐ง๐๐๐ง ๐จ๐ช๐๐๐๐๐ก๐ ๐ซ๐ค๐ก๐ช๐ข๐๐จ ๐๐ฃ ๐๐/๐พ๐๐ ๐ฅ๐๐ฉ๐๐๐ฃ๐ฉ๐จ ๐ข๐๐๐ฉ๐๐ฃ๐ ๐ค๐ฃ๐ก๐ฎ ๐๐พ๐พ ๐๐ง๐๐ฉ๐๐ง๐๐.
- Therefore, our study demonstrated that ๐จ๐ฉ๐ง๐๐๐ฉ ๐๐๐จ๐ ๐๐๐๐๐ฃ๐๐ฉ๐๐ค๐ฃ๐จ ๐๐ง๐ ๐๐จ๐จ๐๐ฃ๐ฉ๐๐๐ก in the investigation of the ๐ฅ๐๐ฉ๐๐ค๐ฅ๐๐ฎ๐จ๐๐ค๐ก๐ค๐๐ฎ ๐ค๐ ๐๐/๐พ๐๐.
Abstract:
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients suffer from a cognitive and memory dysfunction. Because the hippocampus plays a key role in both cognition and memory, we tested for volumetric differences in the subfields of the hippocampus in ME/CFS.
We estimated hippocampal subfield volumes for 25 ME/CFS patients who met Fukuda criteria only (ME/CFSFukuda), 18 ME/CFS patients who met the stricter ICC criteria (ME/CFSICC), and 25 healthy controls (HC).
Group comparisons with HC detected extensive differences in subfield volumes in ME/CFSICC but not in ME/CFSFukuda. ME/CFSICC patients had significantly larger volume in the left subiculum head (pโ<โ0.001), left presubiculum head (p = 0.0020), and left fimbria (p = 0.004).
Correlations of hippocampus subfield volumes with clinical measures were stronger in ME/CFSICC than in ME/CFSFukuda patients. In ME/CFSFukuda patients, we detected positive correlations between fatigue and hippocampus subfield volumes and a negative correlation between sleep disturbance score and the right CA1 body volume. In ME/CFSICC patients, we detected a strong negative relationship between fatigue and left hippocampus tail volume. Strong negative relationships were also detected between pain and SF36 physical scores and two hippocampal subfield volumes (left: GC-ML-DG head and CA4 head).
Our study demonstrated that volumetric differences in hippocampal subfields have strong statistical inference for patients meeting the ME/CFSICC case definition and confirms hippocampal involvement in the cognitive and memory problems of ME/CFSICC patients.
We estimated hippocampal subfield volumes for 25 ME/CFS patients who met Fukuda criteria only (ME/CFSFukuda), 18 ME/CFS patients who met the stricter ICC criteria (ME/CFSICC), and 25 healthy controls (HC).
Group comparisons with HC detected extensive differences in subfield volumes in ME/CFSICC but not in ME/CFSFukuda. ME/CFSICC patients had significantly larger volume in the left subiculum head (pโ<โ0.001), left presubiculum head (p = 0.0020), and left fimbria (p = 0.004).
Correlations of hippocampus subfield volumes with clinical measures were stronger in ME/CFSICC than in ME/CFSFukuda patients. In ME/CFSFukuda patients, we detected positive correlations between fatigue and hippocampus subfield volumes and a negative correlation between sleep disturbance score and the right CA1 body volume. In ME/CFSICC patients, we detected a strong negative relationship between fatigue and left hippocampus tail volume. Strong negative relationships were also detected between pain and SF36 physical scores and two hippocampal subfield volumes (left: GC-ML-DG head and CA4 head).
Our study demonstrated that volumetric differences in hippocampal subfields have strong statistical inference for patients meeting the ME/CFSICC case definition and confirms hippocampal involvement in the cognitive and memory problems of ME/CFSICC patients.