Vit. D causing allergies to flareup

[cristi_b]

normally I'm not sure if I have a histamine problem based on the fact that I can usually eat high histamine foods without issues.

Histamine issues from food are not always apparent, I have lived for all my life(I am 40 now) and did not realize that I have a genetic DAO deficiency until I took a genetic test. This happens because you don't get symptoms immediately after eating(like in a peanut allergy), histamine usually builds up as the DAO enzyme gets overwhelmed and you won't be able to match symptoms to what you ate past few days. Furthermore histamine could be coming from mast cell activation which is even harder to predict, mast cells can be anywhere and get activated by things like LPS in the gut.

Does vitamin A increase the histamine load?

I was thinking at 2 possibilities when I said that:
- allergens in the supplement itself(if it was a cheap one), that would cause histamine to be released directly
- vitamin A helps the immune system: it enhances the antibody response and supports the growth and activation of T and B cells; If you have an infection in the body that creates LPS(this was suggested by your reaction to vitamin D) you will get more LPS from further activation of the immune system, and said LPS will trigger mast cells to release more histamine.

I am very curios to see what reaction you have(if it's any of the above two), so please share.

Since even later 10,000 iu of D3 at a time wasn't able to produce anything like the first dose of 5000 iu

I have a few thoughts on that:
1) maybe it's not the same supplement; might be a good idea to try again the same supplement that caused it
2) for whatever reason you don't have as much histamine in your system as you did when you initially tryed it
3) MAO and HNMT enzymes work better now and so eliminate excess histamine faster from your brain
4) the inital dose ramped up the immune system and killed most of the LPS-producing infection, since there isn't that much bacteria now you won't get the same response

Can't find anything on that myself. I've been thinking about keeping DAO on hand for emergency immune implosion situations, which one do you recommend?

DAO enzyme supplements do not work for emergency, it is the same as for Histamine you get from food, it builds up and goes down over several days. DAO enzyme supplements are basically taken during a meal to degrade the histamine you get from that meal, so the body doesn't get additional histamine from what you eat. If you do that for all meals of the day, for several days, the body doesn't get any histamine from food and has time to process histamine that is already in the system. Only then will histamine go down. So as you can tell, this doesn't help in the short term, but only after several days. For short term emergency situations, you can take anti-histamine medication or Quercetin.

 

[Dysfunkion]

Histamine issues from food are not always apparent, I have lived for all my life(I am 40 now) and did not realize that I have a genetic DAO deficiency until I took a genetic test. This happens because you don't get symptoms immediately after eating(like in a peanut allergy), histamine usually builds up as the DAO enzyme gets overwhelmed and you won't be able to match symptoms to what you ate past few days. Furthermore histamine could be coming from mast cell activation which is even harder to predict, mast cells can be anywhere and get activated by things like LPS in the gut.


I was thinking at 2 possibilities when I said that:
- allergens in the supplement itself(if it was a cheap one), that would cause histamine to be released directly
- vitamin A helps the immune system: it enhances the antibody response and supports the growth and activation of T and B cells; If you have an infection in the body that creates LPS(this was suggested by your reaction to vitamin D) you will get more LPS from further activation of the immune system, and said LPS will trigger mast cells to release more histamine.

I am very curios to see what reaction you have(if it's any of the above two), so please share.


I have a few thoughts on that:
1) maybe it's not the same supplement; might be a good idea to try again the same supplement that caused it
2) for whatever reason you don't have as much histamine in your system as you did when you initially tryed it
3) MAO and HNMT enzymes work better now and so eliminate excess histamine faster from your brain
4) the inital dose ramped up the immune system and killed most of the LPS-producing infection, since there isn't that much bacteria now you won't get the same response


DAO enzyme supplements do not work for emergency, it is the same as for Histamine you get from food, it builds up and goes down over several days. DAO enzyme supplements are basically taken during a meal to degrade the histamine you get from that meal, so the body doesn't get additional histamine from what you eat. If you do that for all meals of the day, for several days, the body doesn't get any histamine from food and has time to process histamine that is already in the system. Only then will histamine go down. So as you can tell, this doesn't help in the short term, but only after several days. For short term emergency situations, you can take anti-histamine medication or Quercetin.

Never thought about histamine building up so high that I'm not getting symptoms upon eating more of it, there's also the possibility that all that histamine is stuck in certain areas of body more so than others in areas where I don't for example feel like my face or any other area is on fire. I know for a fact when I'm having a reaction to something I can get intense brain fog and other neurological issues even without the extreme histamine feeling in my face where before my fatigue got even worse would get the most symptoms with burning/tingling skin. I'll always feel something there but the skin sensation feelings aren't as intense anymore which is probably a byproduct of my body failing to have enough power to even amp the nervous system up enough to do that. From my last experience with the thiamine I can see now I certainly can have a signalling overload going on in my nervous system without actually engaging the sympathetic nervous system much which actually appears to be a big part of my issue. My body appears to have the gears jammed in the opposite direction despite even getting stimulation. I also know from my experiences with tyrosine and way back when I upped how much coffee I was drinking a day that rises in dopamine or serotonin are not able to break the stimulation barrier that the initial 5000 iu lichen D3 dose was able to and experiencing an intense fight or flight reaction also isn't able to do so either so it seems to be occurring by some other mechanism that this energy is being inhibited by.

The d3 supplement that did it was the vegan 5000 iu D3 a dose from Country Life, it was the same one I took a 10,000 iu dose from and wasn't able to repeat the initial reaction to the first 5000 iu dose. The other additives in it I'm able to consume and not have a reaction to so if it was something it was made with the additive isn't listed. Smaller doses I tried in between that came from drops of vegan D3 made with only MCT oil but after the initial reaction everything from this form would produce the same results. No stimulation, some of the positives, and a lot more side effects. The only form of D3 that was able to do this was the vegan lichen derived form, the sheep wool form would just make me more tired, same goes for the D2 form. It also could be that my immune system after it was ramped up like that was able to fight back an infection it was too weak to do so against before. Hoping the vitamin A will give me more direction on where to push here, since it's such a low amount right under the daily value I may not even have much of a response at all who knows. I'll give it a go on Thursday when I have a couple days off should anything go wrong which I'm not really expecting but who knows.

Would DAO have a chance of causing a start up reaction from a large amount of histamine backup being processed all at once? Reviews on it appear to be all over the place on DAO supplements. I haven't done any other research into it so I'm not sure if it can do other things in the body besides that.

 

[cristi_b]

Would DAO have a chance of causing a start up reaction from a large amount of histamine backup being processed all at once?

From the information I found, a large amount of histamine usually overwhelms the DAO enzyme causing it to function more poorly than your usual rate. In order for DAO enzyme activity to recover you have to lower the load. I think this is what I did when I took DAOSiN and, in a matter of days, I've observed complete disappearance of cardiac arrhythmia (they have not returned by the way)
Just as a sidenote: lots of people experience heart palpitations / extra systoles / arrhythmias and the funny thing is, cardiologists sometimes suggest surgeries to "correct" the issue! I managed to solve mine with DAOSiN!

Reviews on it appear to be all over the place on DAO supplements. I haven't done any other research into it so I'm not sure if it can do other things in the body besides that.

I know that DAOFood is the most powerfull DAO supplement, followed by DAOSiN. You can find information in this study.
By the way: DAOFood Plus is just DAOFood with some Quercetin in it.

Hoping the vitamin A will give me more direction on where to push here, since it's such a low amount right under the daily value I may not even have much of a response at all who knows. I'll give it a go on Thursday when I have a couple days off should anything go wrong which I'm not really expecting but who knows.

I just want to point out that if it really was an infection that caused the initial sympathetic reaction from vitamin D, you should not want it again. Inundating your system with high amounts of Histamine from LPS is not a healthy choice. This is what I did and I got cognitive problems from it. I wish I knew at that moment to take some supplements for protection of neurons from LPS.
If you want to go that route, to generate Histamine from LPS, I can tell you that for me the HN019 probiotic produced a much stronger reaction than simple vitamin D. But I strongly advise anyone who tryes to kill bacteria in the gut to protect their neurons: solve leaky gut first and take supplements that protect against LPS.

 

[linusbert]

know I read somewhere that some diabetes medication affect DAO enzyme, but I don't think it was pioglitazone. Are there any changes to your allergies when you get weaker legs? If your allergies remain the same, it could also be a neurologic issue. Perplexity AI says "the enzymes involved in vitamin D metabolism are distinct from those involved in the metabolism of pioglitazone, which is primarily metabolized by CYP2C8 and CYP3A4", so there doesn't seem to be a direct link between vitamin D and pioglitazone.

i am not sure if there is a relation between legs and my allergies. but they definitely didnt get better when i had the mega dosing of vitamin D the last year.
but i get same results with worse legs when overdoing it like typing a lot or playing too much videogames. it seams to draw from the legs first and i notice only a few hours or day later.

i found a different conclussion with chatgpt, there is indeed a overlap in enzymes. leading to pioglitazon being metabolized faster. dont know how big that effect is though.

 

[cristi_b]

i found a different conclussion with chatgpt, there is indeed a overlap in enzymes. leading to pioglitazon being metabolized faster. dont know how big that effect is though.

I have asked perplexity again and now it spit out this study:
Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4

(I typically use AI chatbots so I don't have to search for and read so many research papers, but it seems that sometimes these AIs make mistakes)

but i get same results with worse legs when overdoing it like typing a lot or playing too much videogames. it seams to draw from the legs first and i notice only a few hours or day later.

Don't want to seem pushy, but it might be worth to checkout the neurological / vagus nerve hypothesis also. I have found some research papers stating that pioglitazone affects both the sympathetic and parasympathetic nervous system. Both are part of the A.N.S.(Autonomic Nervous System) and, as the name implies, function independently of conscious control. Just a few links I found with perplexity about this subject:

1) Metformin and pioglitazone inhibited vagus nerve mediated airway hyperreactivity in diet-induced obese rats

Conclusions: Hypoglycemic drugs (metformin and pioglitazone) reduce parasympathetic nerve mediated airway hyperreactivity in obese rats, without changing M3 muscarinic receptor function or reducing body weight or fat.

2) Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with alpha-glucosidase inhibitor

pioglitazone significantly decreased muscle sympathetic nerve activity(MSNA) in type 2 diabetes mellitus (DM) patients compared with alpha-GI (21.7±5.2 vs. 32.0±6.8 burst/min, p<0.01)

Full disclosure: I am a believer in the Polyvagal Theory by Dr. S. Porges, so I tend to see lots of correlations to the A.N.S. in everyday life When I read stuff like "overdoing it like typing a lot or playing too much videogames" some of the concepts from that theory come to mind.

 

[cristi_b]

Oh.. just remembered some supplements that might be helpful:

1) Taurine: I found it very effective at solving trembling in hands, I actually give it to my father as he has diabetes. He seemed also to be more stable on his feet(he has an A.D. diagnosis also). Taurine has been proven to have several beneficial effects on neurons, you can get information on that with AI chatbots. You may also find that Taurine improves blood sugar levels, that is a bonus!

2) HMB = Hydroxy Methyl Butyrate: I've tried this supplement and found it to enhance the ventral vagal state(this is the ideal state from the Polyvagal Theory). Best I can describe the effect is: reduced stress, higher heart rate variability. Since pioglitazone is known to screw around with the Autonomous Nervous System(see research papers above), I would recommend you to try HMB to see if it returns you to the ideal state. This supplement is proven to bind to the PPAR-alpha receptor, see here.

 

[linusbert]

HMB i tried, did nothing.

Taurine last time i tried did worsen cramping, but was years ago , might try again. taurine works in calcium metabolism too.

Full disclosure: I am a believer in the Polyvagal Theory by Dr. S. Porges, so I tend to see lots of correlations to the A.N.S. in everyday life When I read stuff like "overdoing it like typing a lot or playing too much videogames" some of the concepts from that theory come to mind.

its not video games. its general increased arm activity, also from writing emails or coding. i suspect it drawing energy from legs. aka my legs powering my arms. thus burning my muscles... which is not optimal

I have asked perplexity again and now it spit out this study:
Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4

ok, read it, but i do not understand the impliciations for me. but there is definitely going something on on that enzyme between D and pioglitazone for sure.
.

checkout the neurological / vagus nerve hypothesis also

whats that.

 

[LINE]

@cristi_b I read your post - any testing on gut bugs?

 

[cristi_b]

whats that.

Polyvagal theory is maybe a too complex subject to be explained in a few words, perhaps I should not even try because I might say something inexact and you would easily dismiss the concepts. You can read about it if you'd like or ask a chatbot to summarize the theory. For me taking vitamin D also brought on some symptoms of a dorsal vagal state(in addition to, or perhaps because of, the histamine overload symptoms): I would get tired, my legs would feel heavy, I would feel the need to sleep and I would actually oversleep during the night. Basically the A.N.S. would not allow the C.N.S. to be up and about. As mentioned previously, two times that I stubbornly took vitamin D I almost fainted. What you were describing as "weak legs" made me think of the same state I got from vitamin D: the start of dorsal vagal shutdown(fainting). I also know an other person who experiences something similar, but has a different trigger: his legs are shaking so much he cannot walk properly and at some point he just falls off his feet(though he remains conscious, so not a full faint). It would be interesting to see what your heart rate is during the "weak legs" episodes, is it lower/higher than usual and does it have variability on breathing in and breathing out. That would be an indication of the vagal state you have at that moment. For example I have an oxymeter on my desk and I use it to check if I'm in the "ideal" state from time to time. Also I use simple exercises that can bring the A.N.S. in the "ideal" state: something as simple as diaphragmatic breathing. This brings me to one of the pitfalls of "typing", "playing videogames", "writing email", "coding", you sit down at a desk or on the couch and breathe just be the top of the lungs and so go out of the "ideal"(stress free) state. Anyway... I may be way off

HMB i tried, did nothing.

I meant to try HMB now(after pioglitazone), but only small quantities like 400mg as to not have a direct impact on the muscle, just for the effects on the nervous system. It would be interesting to see if it will increase your heart rate variability. As mentioned previously, my guess is you are not in the "ideal" state.

I read your post - any testing on gut bugs?

I was tested for the usual culprits(E Coli, Campylobacter and stuff), I also payed for some advanced testing of parasites by PCR method(Giardia lamblia, Entamoeba histolytica, Cryptosporidium spp., Blastocystis hominis, Dientamoeba fragilis, Cyclospora cayetanensis, Strongyloides spp., Necator americanus, Ascaris spp., Trichuris trichura, Enterobius vermicularis, Taenia spp., Ancylostoma spp., Hymenolepsis spp., Enterocytozoon spp/Encephalitozoon spp.) and ALL were negative. These "positive" / "negative" tests don't seem that useful to me.

When I did the Nebula genomics test(last year, when I felt horrible), they also did an oral microbiome test, which is much more detailed and showed some modifications from normal:
Prevotella: 27.33% abundance, 95% percentile(95% of people they tested have a lower value)
Fusobacterium: 16.72% abundance, 95% percentile
Porphyromonas: 8.52% abundance, 95% percentile
Streptococcus: 6.03% abundance, 5% percentile
Veillonella: 6.02% abundance, 60% percentile
Tannerella: 4.26% abundance, 95% percentile
Campylobacter: 3.73% abundance, 95th percentile
Filifactor: 1.38% abundance, 95th percentile
Selenomonas: 0.65% abundance, 95th percentile

They tell me some of these values are linked by studies to I.B.D.

I know I should get some microbiome stool test, but have not decided yet which one and they also seem expensive in my country(they have to be sent abroad in US, Germany and some other country, I don't remember which one).

 

[Dysfunkion]

Polyvagal theory is maybe a too complex subject to be explained in a few words, perhaps I should not even try because I might say something inexact and you would easily dismiss the concepts. You can read about it if you'd like or ask a chatbot to summarize the theory. For me taking vitamin D also brought on some symptoms of a dorsal vagal state(in addition to, or perhaps because of, the histamine overload symptoms): I would get tired, my legs would feel heavy, I would feel the need to sleep and I would actually oversleep during the night. Basically the A.N.S. would not allow the C.N.S. to be up and about. As mentioned previously, two times that I stubbornly took vitamin D I almost fainted. What you were describing as "weak legs" made me think of the same state I got from vitamin D: the start of dorsal vagal shutdown(fainting). I also know an other person who experiences something similar, but has a different trigger: his legs are shaking so much he cannot walk properly and at some point he just falls off his feet(though he remains conscious, so not a full faint). It would be interesting to see what your heart rate is during the "weak legs" episodes, is it lower/higher than usual and does it have variability on breathing in and breathing out. That would be an indication of the vagal state you have at that moment. For example I have an oxymeter on my desk and I use it to check if I'm in the "ideal" state from time to time. Also I use simple exercises that can bring the A.N.S. in the "ideal" state: something as simple as diaphragmatic breathing. This brings me to one of the pitfalls of "typing", "playing videogames", "writing email", "coding", you sit down at a desk or on the couch and breathe just be the top of the lungs and so go out of the "ideal"(stress free) state. Anyway... I may be way off

When I push the D I also get the weak legs and at first I got the shaky legs with a lot of stimulation and then it dropped into weak everything and lots of aching. I got there in a different way with the weak everything, stone legs from thiamine too (which thankfully resolved, just kinda brain fatigue-y and a bit heavy today). I'm not sure what it was from as when it got to the point where it was making me very weak I didn't have any burning anywhere if it was a histamine driven immune response from an overload. Who knows it may have a paradox reaction when levels hit a certain point, don't know what entirely went on under the hood.

I'm not sure if they work at all but I was thinking about seeing if I respond this way to D3 patches on the skin, I have a feeling all of these weird reactions with me are gut based before the supplement even really hits where it's supposed to as my reactions begin within minutes of swallowing and it may be different if I bypass the gut. I haven't gotten any microbiome tests myself but I just know its a mess in there and I don't have the money for that right now anyways.

 

[linusbert]

When I push the D I also get the weak legs and at first I got the shaky legs with a lot of stimulation and then it dropped into weak everything and lots of aching. I got there in a different way with the weak everything, stone legs from thiamine too (which thankfully resolved, just kinda brain fatigue-y and a bit heavy today).

what i know is that vitamin D requires lots of potassium. people only talk about magnesium. thats right. but it also draws on potassium, and it also increases on phosphat absorption.
so your weak legs could be a result of that.

mine are a bit different, when i get it, it barely gets better if at all.

 

[Dysfunkion]

what i know is that vitamin D requires lots of potassium. people only talk about magnesium. thats right. but it also draws on potassium, and it also increases on phosphat absorption.
so your weak legs could be a result of that.

mine are a bit different, when i get it, it barely gets better if at all.

Taking magnesium slightly helped at any dose but not much and if I go over 100 mg in other ways I get more tired with citrate giving me more of a boost (though I found taking citrate more than a day in a row really starts to mess up my digestive system more). I haven't found a potassium supplement I could tolerate and the daily value is a huge amount you'll never get from supplements unless something is different about supplementing it than how your body deals with it consumed in food. I get enough food every week but potassium probably isn't optimal though I also know I don't absorb things well from food so what I consume in most food probably isn't going anywhere unless I consume very large amounts of it. I like the citrate form of magnesium got the most benefit out of the potassium citrate but my digestive system also threw a fit when I consumed any. If it didn't I would be taking it right now.

 

[linusbert]

Taking magnesium slightly helped at any dose but not much and if I go over 100 mg in other ways I get more tired with citrate giving me more of a boost (though I found taking citrate more than a day in a row really starts to mess up my digestive system more). I haven't found a potassium supplement I could tolerate and the daily value is a huge amount you'll never get from supplements unless something is different about supplementing it than how your body deals with it consumed in food. I get enough food every week but potassium probably isn't optimal though I also know I don't absorb things well from food so what I consume in most food probably isn't going anywhere unless I consume very large amounts of it. I like the citrate form of magnesium got the most benefit out of the potassium citrate but my digestive system also threw a fit when I consumed any. If it didn't I would be taking it right now.

- potatoes is rich source, also comes with good amounts of magnesium and somewhat phosphat. eat 500-1000g a day and your potassium needs are set. maybe add a little sodium on top.

- coconut water though not everyone tolerates it, they often come loaded with artificial garbage so if you try get a natural which doesnt have any. or buy a coconut, open yourself and drink that water. if it smells and tastes bad dont drink.

 

[linusbert]

@cristi_b i had a new theory recently, that the mcas and histamine issues are worse on over acidic body.
as i notice like you when i take ascorbic acid or vitamin c in plants my immune system goes on overdrive, but when i did mix it with a hydrogencarbonat rich water (1,5g/l +) it seams tolerable without the effect.
so i mix now organic cold pressed acerola juice with that hydrogencarbonat rich mineral water to drink it. which also has the effect of making the acorbic acid convert to ascorbate , the non acidic version.
also the water which is somewhat hard on my stomach probably because of neutralizing the acids, with the juice mixed into, is more tolerable. so i can tolerate the juice and the water.
normal water with natron added to it might work as well.
(you could also mix natron and ascorbic acid which would make it a ascorbate, this is actually the chemical reaction to make ascorbate in products)

my urine ph goes from chronically to low like testing stripes not even changing color to a PH6-7 range.

but after every few days of doing the water i need to stop, thats probably when too much chlorid was wasted from stomach. i notice the stomach effects then. also the urine is then in higher range even without drinking the water. i also need to add more sodium then to my food, to compensate.


the theory isnt out of the blue. its indeed known in vitro that too low PH increases readiness of cells to react with mcas and histamine. its just a question how much influence the oral base supply has to the cells in a complete human body.
so LOW PH in cells increases degranulation of mast cells.

but one must be careful, there is too much acidity and too much alkalinity.. there must be balance where cells work optimal. people tend to go crazy with one or the other. so i highly recommend using the testing stripes and also watch out for symptoms. at some point adding acids like through vinegard and sodium chloride might be necessary.

 

[cristi_b]

Thanks for the info, in the months that I have not written here I went down an other route: being convinced that there is some pathogen(s) in my gut I tried to test my microbiome. 1st I tried to do the "myBiome" test, but even though I tried several times they would not accept my stool sample as it was too loose. Than I found a company in Denmark that does microbiome testing (company is called "UnseenBio") but after sending 2 samples still no luck as they got lost in the mail. So in spite of my best efforts I still don't have any microbiome data to see what is wrong.
Also I tried, with the help of perplexity, to find pathogens that would cause issues with Vit.D and vit.C and other related issues of mine. I may have discovered something while looking for pathogens affecting VDR. The list is the following:

Mycobacterium tuberculosis: While direct effects on VDR have not been extensively studied, vitamin D is known to enhance macrophage function against TB. Therefore, alterations in VDR signaling could influence susceptibility to this pathogen

Aspergillus fumigatus: Vitamin D deficiency has been associated with increased susceptibility to fungal infections like Aspergillus, suggesting that VDR might play a role in modulating immune responses against such pathogens

Salmonella spp.: This pathogen is particularly notable for its ability to regulate VDR activity. Research indicates that Salmonella can increase VDR expression in intestinal cells, which may help the bacteria evade immune responses. The presence of Salmonella has been linked to increased inflammatory responses and a higher risk of diseases like inflammatory bowel disease (IBD) due to its interaction with VDR and modulation of intestinal barrier functions

Borrelia burgdorferi: This bacterium, responsible for Lyme disease, has been shown to significantly reduce VDR expression in monocytes, impairing the immune response and potentially facilitating infection

Shigella spp.: Similar to Borrelia, Shigella can downregulate VDR activity through mechanisms that involve caspase activation, which limits VDR's ability to perform gene transcription

I have done an Aspergillus test last year and it was negative, but when I tested for Mycobacterium Tuberculosis(the Quantiferon Gold Plus test) it came out strongly positive. I have done a lung X-Ray and it doesn't seem to be an active infection of TBC, also a doctor assures me a lot of people can get positive Quantiferon test and are not sick(latent infection), but somehow I don't believe it's not related to my problems. It seems each time I find something doctors say it's not important.

From my own research I find that the Quantiferon Gold Plus test finds all kinds of Mycobacterium infections not just TBC in lungs. There is also a pathogen called Mycobacterium Bovis that, in rare cases, infects the human gut directly by eating contaminated meat. TBC can also infect other organs after lung infection: the kidneys, the gut even the brain. To me it seems this Quantiferon result deserves further investigation, in spite of what the doctor says.

Meawhile my weight has continued to drop, even though I eat a lot of meat I am now at 49.5 Kg(just for reference at the end of high school, I had 54Kg). So basically I'm skinnier that I was at 18years old, for a man of 41 years it looks like I'm very sick. I'm starting to feel weak, I almost fainted on my last blood test. My B12 have dropped significantly and I have tested low for haemoglobin and monocytes, my carnitine levels are low in spite of supplementation, my biotin and pantotheic acid are on the low side though not bellow limit, my Vitamin C is very low. My family doctor says to supplement with 5000 UI of Vitamin D and 100mg of Vitamin C but I cannot take them, as vit.D causes numerous problems and vit.C causes diarrhea.

The only good thing I found in relation to my diarrhea is coconut: I eat one or more Bounty bars per day and it seems to have a good effect on my gut. Somehow the coconut is soothing to my gut. The bad side effect of eating more sugar like Bounty is that my glycated haemoglobin has started to rise: it's 5.8% passing the threshhold for diabetes risk.

I still haven't given up on doing the microbiome test and will try one more time with the UnSeenBio company. Also I'm still waiting for 3 additional blood tests I have ordered for myself: interferon gamma, interleukin 10 and interleukin 1 Betha.

Will let you know if I find something more.

 

[linusbert]

@cristi_b this looks like you got a anaemia of some sort, could be iron, b12 or others.
usually i would say to eat some red meats, but you already say you eat a lot of meat.
did you try "lactoferrin" , its transport molecule for iron, it increases availability of iron in the body.

do you tolerate plain egg yolks separated from the whites?
you can either eat them raw - but need to separate the WHITES, this is the easist to digest for the body, its 30 minutes from eating to body utilizing the proteins to make tissue.
raw comes with the risk of some residue eggwhite causing allergies for some though.
so you can cook them so that the eggwhite gets hard and the yolk somewhat hard but still soft enough, then you can cut with a knife into the center of the egg , then with the hands open it like a nut, and you can extract a ball of pure YOLK and eat that.
i came up with this recently because the peeling of the shell when eating 4-6 eggs is somewhat strainous and takes a lot of time, now it takes like 3 seconds per egg. also no mess to clean up. i need to patent that!

do you eat liver?


there is a more active form of vitamin D, called calciDiol (note the D), you can try that.
and there is the active form calciTriol (note the T). this does immediate effects without conversations, also comes with the risk of adding a active hormone to the body.
the calciDiol may be a good try, it has a short half life like 2 weeks. and is still a step away from the active calciTriol.
its much more active and requires less cofactors as the normal cholecalciferol (vitamin d3) does.
worth a shot.

 

[cristi_b]

@cristi_b this looks like you got a anaemia of some sort, could be iron, b12 or others.

Iron is at medium level(this was a positive change since I was overloaded with iron previous times I tested it), B12 as I said went down a lot but lab did not consider it a deficiency.

do you tolerate plain egg yolks separated from the whites?

Eggs have fats and I usually avoid them because of that. I don't have any issues absorbing B12 supplements but taking this vitamin makes me irritable(sympathetic activation) so I try to only supplement around the daily recommended dose and take breaks when I get too nervous or it affects my sleep.

there is a more active form of vitamin D, called calciDiol (note the D), you can try that.

As I mentioned in an early post I have low inactive vit.D and upper-normal active vit.D. Taking more vit.D would make my allergies worse:

3. Very low 25(OH)D but upper-normal 1,25(OH)2D

I want to thank the user @LINE for the idea that in immune diseases you can have low inactive vitamin D with high/normal active one, this really pointed me in the right direction! Now, at least, I understand some of the stuff that's going on with me. To test the idea I have repeated the vitamin D blood tests and done both active and inactive at the same time so there won't be any discussion about it being done in separate days/period:
- inactive 25(OH)D is now at 11 ng/mL(was initially at 14.4 ng/mL) which is well below the threshold for deficiency
- active 1,25(OH)2D is 61.8 pg/mL whereas normal range is 25-86.5 pg/mL for the lab, this means it is above the middle point of the normal range

I would have expected both to be low but is seems somehow active vitamin D is overproduced.

One thing I realized recently is that whenever my nose is more clear(like when taking more Quercetin combined with Pomegranate) I experience head aches on strong smells. So even if my allergies do not manifest themselves as runny / dripping nose, they will cause head aches. It's getting very difficult to go around them, I just have to avoid smells.

On an other note, the results for interferon gamma, interleukin 10 and interleukin 1 Betha all came out ok. This adds to the list of IL-8, IL-17, IL-6 that were in range. So looking back at the cytokines tests I did, only TNF-alfa was maybe higher, coming out at 7ng/l(where the german lab has reference values <8 ng/l). Now I'm thinking I should have provoked an allergic reaction(by taking vitamin D) to see which cytokines are elevated and don't test them when I am okayish. I probably have wasted the money(and they are quite expensive) by testing them without provoking the allergies.