Thank you for the comments @linusbert My opinion >> MCAS is related to broken methylation cycles and/or liver congestion. IMO, these 2 are closely associated and influence one another. Detoxification strategies got me over the barriers.
For me some of the natural ways to get vitamins like eating food or sun-bathing(for vitamin D) is problematic, maybe not as problematic as supplements but I still have similar issues, for example:what i know is that many artificial supplements give me problems and natural stuff does not.
[...] but why doesnt natural high dose from food does not raise those problems?
I've tried Glutathione and found some interesting effects on my vision: my visual field seemed expanded, I could notice movement better, objects seemed more 3D than usual; unfortunatly there was also some slight heart pain and dilated veins so I've stopped taking it. Did not notice any improvement on my allergies or gut.@linusbert
I would agree that glutathione levels are low in many immune based diseases.
Again I've had a wierd reaction to activated charcoal: lots of intestinal gas and urinary problems. No idea why.Charcoal (activated) is a powerful sweeper of toxins and will help the body detoxify as you mentioned.
Have you thought about having too much of cofactors for vitamin D in your system, stuff like: Magnesium, Boron, Zinc, Selenium, Vitamin K etc ?i really would like to try detox but its not possible for me because every detox agent is somewhat plant extracted.
did you try sodiumascorbate? i can take those gram-wise but normal ascorbic acid gives me diarrhea at mini dosages.- vitamin C(in the form of ascorbic acid) gives me diarrhea and other gastro-intestinal problems, but than again so does natural alternatives like lemons or oranges; today I've tried a low dose of ascorbic acid, about 20mg(I've split up in 4 pieces a 80mg lozenge) and within 1h my stomach started to rumble, also my nose become stuffed, I had to go to the toilet after that
how long after taking the D this happens?if I take vitamin D and afterwards I smell something chemical I will get nose/throat inflammation, headaches, dizziness, a feeling I'm about to faint
some people including myself react to sun light or radiation. when you get sunlight through a UV blocking glas , do you get same symptoms? if yes, its not the vitamin D.vitamin D from the sun also causes problems
can it be that you are sensible to fats in general? you might try TUDCA with those, might improve tolerance for fats. also B2 is very important for fats.Also pills that block absorption of fat soluble vitamins (like A,D,E,K) have an immediate effect on my diarrhea, though, again, not really sure if it's from blocking vitamin D or something else.
i have not, my vitamins of everything are low. boron in hairmineral analysis was actually not measurable... everything else is low normal... maybe i need to take boron??Have you thought about having too much of cofactors for vitamin D in your system, stuff like: Magnesium, Boron, Zinc, Selenium, Vitamin K etc ?
how is your retinol? did you try to increase retinol intake with D intake. you might play around with ratios... increase retinol to D ratio. beta carotene isnt much use.I started out this discussion because I thought that my body does not accept vitamin D because of missing cofactors, now I'm thinking taking cofactors was a big mistake as supplementing these cofactors has amplified my allergies. Too much active vitamin D is making my allergies worse and active vitamin D is obtained from inactive vitamin D and cofactors. Now, because of my blood test, I know for sure I was and probably still am Magnesium deficient, but this was also a limiting step in producing active vitamin D: the more magnesium I supplement right now, the more active vitamin D I will have and my allergies will get worse.
Is this too far fetched?
No, I have not tried it, but it's ordered and arriving today(hopefully!). Since it's not that acidic it should be easier on my stomach, but unfortunately I've come across the information that vitamin C(in all forms) is a DAO inhibitor. This could still make my diarrhea worse because of poor DAO, I will have to test and see.did you try sodiumascorbate? i can take those gram-wise but normal ascorbic acid gives me diarrhea at mini dosages.
After taking vitamin D my allergies are worse for a few days, the exact number varies depending on what quantity I took.how long after taking the D this happens?
I mostly stay indoors(about 99% of time) and if I do not open the window my allergies are manageable. However when I go outside, problems start almost immediately(mast cells are said to be the fastest to react to stimuli, in a matter of seconds).some people including myself react to sun light or radiation. when you get sunlight through a UV blocking glas , do you get same symptoms? if yes, its not the vitamin D.
Indeed I am! Fats give me gas and make my diarrhea worse, hopefully it's not from facilitating vitamin D absorption but something else. I have ordered a B2 supplement and I will test to see if it makes a difference. Thanks!can it be that you are sensible to fats in general? you might try TUDCA with those, might improve tolerance for fats. also B2 is very important for fats.
Worth a tryi have not, my vitamins of everything are low. boron in hairmineral analysis was actually not measurable... everything else is low normal... maybe i need to take boron??
As far as I've read, retinol is involved in vitamin D metabolism after calcitriol binds to VDR. Since I have upper-normal calcitriol and I observe a reaction in my immune system(allergies) I would guess I have enough retinol. I've actually supplemented with vitamin A along with the cofactors, but don't know if it was retinol or beta carotene as it is not specified on the packaging. Beta carotene is converted into retinol at varing ratios depending on BCO1 gene. As I have my complete genome from Nebula genomics I will check if I have any mutation in that gene that causes low retinol conversion, otherwise it's a dead end because supplementing with any vitamin A yields retinol. I will let you know if I find anything.how is your retinol? did you try to increase retinol intake with D intake. you might play around with ratios...
I tryed Potassium in the past, I get into trouble with urinary issues(dribbling, urgency) when I supplement it. Don't know why and haven't managed to solve it, my latest theory is it's somehow related to high Histamine as I've seen a study linking mast cells with bladder issues.also try to up potassium. D really sucks on it.
I have high levels of iron and ferritin in my blood. This is in spite of very high Hepcidin (a hormone that is suppose to block iron absorption), it's sort of a mistery how my body absorbed so much iron. High hepcidin is linked to inflamation which could be a link to Histamine, DAO insufficiency and mast cells disease. Once I solve the histamine issue I will have to circle back and see if my iron levels go down.maybe even iron?
Dr. Marshall was saying in a presentation that inactive vitamin D actually blocks VDR while active vitamin D activates it. As I have very low inactive and upper-normal active form of vit.D the VDR is mostly activated and my immune system goes into overdrive. Now active form should be tightly regulated, that is if it's actually produced by the kidneys, but, as LINE pointed out, some cells of the immune system can do the conversion in an unregulated way. For example in the case of granulomas in the lungs, ingested vitamin D would be converted into possibly too much active form(as it's unregulated). As a coincidence I have spots on my lungs and doctors are always wondering what it is when they take an X-Ray: I'm not a smoker, nor do I have cancer. This is just a wild theory of mine, hope I can confirm or disprove it. Actually, if I think about it, I could just buy the active form of vitamin D(there would be no cofactors needed to activate it) and see what that does, but I'm little scared of a severe activation of the immune system(I have had situations in the past where it was somewhat difficult to breath). Will let you know if I go through with it.i do not believe (without any scientific reasonable explanation) that cofactors might cause this. what i actually believe is that one cofactor is still missing.
I realize my reaction is the complete opposite: 4000 UI made my body react very bad. Dr. Marshall was saying that VDR can be infected by some pathogens, maybe that's my case. I use to take Desloratadine(anti-histamine) to keep allergies under control, but unfortunately recently it does not work so well and seems to cause some stomach upset.before i was reacting this bad with allergies/mcas , vitamin D actually improved my allergies substantially and also inflammation and others just the next day of taking just 5000 iu.
Might be a good idea to do a full DNA sequencing, there's lots of clues there, but it still requires reading. For example I found out about the DAO deficiency while reading medical studies as it was not included in any report. It's great to be able to check stuff when new studies come out.i have a copper deficiency which is somehow not responding to anything, except with nausea and vertigo.
it doesnt even have to be a vitamin or mineral, it could be a amino acid as well... its so disgusting figuring this out.
thats not quiet correct. for healthy people that is. but those conversations of vitamins in the body are highly complex and require that ALL cofactors are present. if one is missing that conversation will not work and beta carotene in that case might be just useless.otherwise it's a dead end because supplementing with any vitamin A yields retinol. I will let you know if I find anything.
i would suspect you are actually low on sodium. try combining the potassium with sodium.I tryed Potassium in the past, I get into trouble with urinary issues(dribbling, urgency) when I supplement it.
lactoferrin might be worth a try, actually its to fix iron deficiency, but its a transporter. might work both ways getting it in and out. NOT SURE about this. needs to be read again.I have high levels of iron and ferritin in my blood. This is in spite of very high Hepcidin (a hormone that is suppose to block iron absorption), it's sort of a mistery how my body absorbed so much iron. High hepcidin is linked to inflamation which could be a link to Histamine, DAO insufficiency and mast cells disease. Once I solve the histamine issue I will have to circle back and see if my iron levels go down.
sarcoidosis?Dr. Marshall was saying in a presentation that inactive vitamin D actually blocks VDR while active vitamin D activates it. As I have very low inactive and upper-normal active form of vit.D the VDR is mostly activated and my immune system goes into overdrive. Now active form should be tightly regulated, that is if it's actually produced by the kidneys, but, as LINE pointed out, some cells of the immune system can do the conversion in an unregulated way. For example in the case of granulomas in the lungs, ingested vitamin D would be converted into possibly too much active form(as it's unregulated). As a coincidence I have spots on my lungs and doctors are always wondering what it is when they take an X-Ray: I'm not a smoker, nor do I have cancer. This is just a wild theory of mine, hope I can confirm or disprove it. Actually, if I think about it, I could just buy the active form of vitamin D(there would be no cofactors needed to activate it) and see what that does, but I'm little scared of a severe activation of the immune system(I have had situations in the past where it was somewhat difficult to breath). Will let you know if I go through with it.
that was back then. now its not working anymore like this for me.I realize my reaction is the complete opposite: 4000 UI made my body react very bad. Dr. Marshall was saying that VDR can be infected by some pathogens, maybe that's my case. I use to take Desloratadine(anti-histamine) to keep allergies under control, but unfortunately recently it does not work so well and seems to cause some stomach upset.
The only thing that works at the moment is Quercetin but the effect doesn't last very long, I have to take multiple doses. Coincidentally Quercetin is said to activate VDR(might be similar to Olmesartan in that sense) and also stabilise mast cells.
i did WGS. nothing so far explaining it for me.Might be a good idea to do a full DNA sequencing, there's lots of clues there, but it still requires reading.
My experience is not nearly as bad, but I do feel that may hay fever (birch, pine and rye pollen mainly) are getting worse when I am sunbathing. Haven't tried if it also happens with Vit. D supplements.Has anyone else encountered such a bad reaction from vitamin D?
I've seen some information today about Aspergillus fumigatus getting into lungs and causing problems which got me thinking and next time I will do blood tests I will also test for this. There are several reasons I found this interesting:sarcoidosis?
vitamin D is controversial here. i cannot give any recommendations.
often sarcoidosis resolves automatically at some point in time.
For some time now I've noticed that my allergies get worse even if I don't sunbathe: just by opening the windows in my room, this could mean I am also allergic to something in the air. I've found a test called ALEX2 which analyzes responses to 295 allergens(some of which are molds). I will simply have to take this test to see what I find.My experience is not nearly as bad, but I do feel that may hay fever (birch, pine and rye pollen mainly) are getting worse when I am sunbathing. Haven't tried if it also happens with Vit. D supplements.
could it be due to increased exposure by beeing outside?My experience is not nearly as bad, but I do feel that may hay fever (birch, pine and rye pollen mainly) are getting worse when I am sunbathing. Haven't tried if it also happens with Vit. D supplements.
thats interesting , how to treat it?I've seen some information today about Aspergillus fumigatus getting into lungs and causing problems which got me thinking and next time I will do blood tests I will also test for this. There are several reasons I found this interesting:
That's a great point, but I don't think so because I am getting my sunlight exposure in 30 minutes around noon on the balcony. On other days, I am outdoors for longer without exposure of the skin (so not much Vit D produced) and don't have the same flare up.could it be due to increased exposure by beeing outside?
best would be to try behind a UV blocking window.That's a great point, but I don't think so because I am getting my sunlight exposure in 30 minutes around noon on the balcony. On other days, I am outdoors for longer without exposure of the skin (so not much Vit D produced) and don't have the same flare up.
That's why I suspect it's the Vit D. Of course, it could also be another effect of the sunlight, e.g., on the immune system. But I strongly suspect it's Vit. D. I should some day check this by taking a high-dose supplement and see if there is the same effect.
I would like to know what you found out about your SNPs because my husband has been getting flares of severe respiratory issues from taking vit D (even penumonia) along the past 8 years (I must add he does have liver issues from both specific SNPs and previous infections). He is +/- for 3 vit A SNPs:As far as I've read, retinol is involved in vitamin D metabolism after calcitriol binds to VDR. Since I have upper-normal calcitriol and I observe a reaction in my immune system(allergies) I would guess I have enough retinol. I've actually supplemented with vitamin A along with the cofactors, but don't know if it was retinol or beta carotene as it is not specified on the packaging. Beta carotene is converted into retinol at varing ratios depending on BCO1 gene. As I have my complete genome from Nebula genomics I will check if I have any mutation in that gene that causes low retinol conversion, otherwise it's a dead end because supplementing with any vitamin A yields retinol. I will let you know if I find anything.
those SNPs are reduced conversion rate from beta carotene to retinol, so what i could imagine is that he is imbalanced by the D as A is the counter part to it. also might be low or deficient in A/retinol. oral D can even cause depletion of A in the liver.I would like to know what you found out about your SNPs because my husband has been getting flares of severe respiratory issues from taking vit D (even penumonia) along the past 8 years (I must add he does have liver issues from both specific SNPs and previous infections). He is +/- for 3 vit A SNPs:
BCMO1 rs4889294 CT +/- risk allele C
BCMO1 R267S rs12934922 AT +/- risk allele T
BCMO1 A379V rs7501331 CT risk allele T
My thoughts exactly.those SNPs are reduced conversion rate from beta carotene to retinol, so what i could imagine is that he is imbalanced by the D as A is the counter part to it. also might be low or deficient in A/retinol. oral D can even cause depletion of A in the liver.
increased respiratory issues can be a sign of A deficiency. so taking D can aggravate that.
Not really.does he have any other symptoms of A deficiency, like eye problems , night vision problems?
He can't eat liver due to iron overload.did you try some retinol , best in form of liver?
Sounds like a good combo, I am just not sure about C due to the iron issue... I think ALA is a must to chelate iron and improve insulin sensitivity. Supplements are actually quite hard for us, there is always an undesired effect around the corner... Mostly headaches.vitamin A / D and zink and selen and C work in concert.