Unfolded Protein Response and A Possible Treatment for CFS

[Gondwanaland]

Ha! That's my husband's kind of diet, for sure. I worry about my husband's insulin, too. I don't know the answer to a diet to correct the creatinine and then keep triglycerides and insulin down, too. Well, I guess that would be a diet high in vegetables.

He isn't tolerating anything sulfury right now

 

[mariovitali]

I think it is his herniated disk.

Hmm i have a question here. Where is this pain located? Around the waist area perhaps?

 

[Gondwanaland]

Hmm i have a question here. Where is this pain located? Around the waist area perhaps?

Exactly

 

[mariovitali]

Exactly

What i think is going on is that the pain is of neurological origin. What your husband experiences is the negative effects from impaired calcium homeostasis.

Has your husband tried Calcium supplementation and does he have the same symptoms (ie waist pain) when he takes calcium supplements? If he hasn't tried Calcium supplementation then you can try it out but make sure that you do not give too much calcium. A quarter or half a tablet will do i think.

Note that D3 and K2 directly influence Calcium homeostasis and since the functionality of the Endoplasmic Reticulum is not in good shape then that means that ER Stress takes place.

Under normal circumstances, Calcium overload can be handled appropriately but as this theory suggests, anything that creates ER Stress (including Calcium supplementation or enhanced absorption) is not our friend.

 

[Violeta]

What i think is going on is that the pain is of neurological origin. What your husband experiences is the negative effects from impaired calcium homeostasis.

Has your husband tried Calcium supplementation and does he have the same symptoms (ie waist pain) when he takes calcium supplements? If he hasn't tried Calcium supplementation then you can try it out but make sure that you do not give too much calcium. A quarter or half a tablet will do i think.

Note that D3 and K2 directly influence Calcium homeostasis and since the functionality of the Endoplasmic Reticulum is not in good shape then that means that ER Stress takes place.

Under normal circumstances, Calcium overload can be handled appropriately but as this theory suggests, anything that creates ER Stress (including Calcium supplementation or enhanced absorption) is not our friend.

Why would the pain be particularly at the vertebrae at the waist?

 

[mariovitali]

Why would the pain be particularly at the vertebrae at the waist?

I had the exactly same symptom. The most interesting thing though was what was happening after this type of pain. I would get recurring occurrences of constipation.

Recall that i kept record for more than 400 days and some things became apparent only after after the analysis that was performed.

 

[Violeta]

I had the exactly same symptom. The most interesting thing though was what was happening after this type of pain. I would get recurring occurrences of constipation.

Recall that i kept record for more than 400 days and some things became apparent only after after the analysis that was performed.

And your protocol for ER corrected it? Which would mean it corrected calcium metabolism? That would be good news.

 

[mariovitali]

And your protocol for ER corrected it? Which would mean it corrected calcium metabolism? That would be good news.

I am not sure if it is calcium metabolism only and i do not know what will happen if i stop my regimen. There are really crazy things happening to me. I don't want to get carried away but i am more than certain that my hearing is better than 10 years ago. I write music and i can tell the difference because i am hearing sounds that i couldn't hear before.

The more we age, the more our hearing frequency response is negatively affected.


Another thing is my eye floaters. When i was taking 750 mg of TUDCA my eye floaters started dissapearing.

Hopefully, this will continue

 

[Violeta]

I am not sure if it is calcium metabolism only and i do not know what will happen if i stop my regimen. There are really crazy things happening to me. I don't want to get carried away but i am more than certain that my hearing is better than 10 years ago. I write music and i can tell the difference because i am hearing sounds that i couldn't hear before.

The more we age, the more our hearing frequency response is negatively affected.


Another thing is my eye floaters. When i was taking 750 mg of TUDCA my eye floaters started dissapearing.

Hopefully, this will continue

I am not sure if it is calcium metabolism only and i do not know what will happen if i stop my regimen. There are really crazy things happening to me. I don't want to get carried away but i am more than certain that my hearing is better than 10 years ago. I write music and i can tell the difference because i am hearing sounds that i couldn't hear before.

The more we age, the more our hearing frequency response is negatively affected.


Another thing is my eye floaters. When i was taking 750 mg of TUDCA my eye floaters started dissapearing.

Hopefully, this will continue

I have eye floaters and am having difficulty with high frequencies in my right ear. Eye and ear symptoms are definitely early warnings, so good to take care of. Did you say earlier your tinnitus has cleared up?

What brand of TUDCA do you take?

 

[mariovitali]

I have eye floaters and am having difficulty with high frequencies in my right ear. Eye and ear symptoms are definitely early warnings, so good to take care of. Did you say earlier your tinnitus has cleared up?

What brand of TUDCA do you take?

It's from Premium Powders, 250 mg per Tablet. I was taking up to 750 mg for 2 months.

Yes, i had incidences of Tinnitus that would last 1-5 seconds (unilateral) now all is good

 

[Gondwanaland]

What i think is going on is that the pain is of neurological origin. What your husband experiences is the negative effects from impaired calcium homeostasis.

Yes it is neurologic. In 2011 he had surgery to decompress the left ulnar nerve. The right nerve was swelling as well but then we went gluten free and his right arm healed.

Has your husband tried Calcium supplementation and does he have the same symptoms (ie waist pain) when he takes calcium supplements? If he hasn't tried Calcium supplementation then you can try it out but make sure that you do not give too much calcium. A quarter or half a tablet will do i think.

Many years ago, before we got married, he used to take tribasic calcium phosphate. Perhaps we should try it again. His serum phosphate is high though, and I hope vit D supplementation will normalize it.

Note that D3 and K2 directly influence Calcium homeostasis and since the functionality of the Endoplasmic Reticulum is not in good shape then that means that ER Stress takes place.

Currently he is being heped by vitamin D (mood), and last week 100mcg of vit K2 triggered his back pain. He is addicted to orange juice, I think due to the calcium content. You alert against it, and Ray Peat to whom the calcium metabolism is the center of everything advocates its consume.

I had the exactly same symptom. The most interesting thing though was what was happening after this type of pain. I would get recurring occurrences of constipation.

He doesn't have constipation (very rarely like 1x every couple of months), he is IBS-D prone.

Yes, i had incidences of Tinnitus that would last 1-5 seconds (unilateral)

I am having tinnitus since late May when I took Boswellia and Miyarisan and apparently had a massive oxalate dump.

 

[Violeta]

Yes it is neurologic. In 2011 he had surgery to decompress the left ulnar nerve. The right nerve was swelling as well but then we went gluten free and his right arm healed.


Many years ago, before we got married, he used to take tribasic calcium phosphate. Perhaps we should try it again. His serum phosphate is high though, and I hope vit D supplementation will normalize it.


Currently he is being heped by vitamin D (mood), and last week 100mcg of vit K2 triggered his back pain. He is addicted to orange juice, I think due to the calcium content. You alert against it, and Ray Peat to whom the calcium metabolism is the center of everything advocates its consume.

He doesn't have constipation (very rarely like 1x every couple of months), he is IBS-D prone.

I am having tinnitus since late May when I took Boswellia and Miyarisan and apparently had a massive oxalate dump.

@Gondwanaland, Articles of Ray Peat and present time forums for Ray Peat type information do advocate calcium as being everything, but I think there has been a big shift in "Ray Peat" information. I started reading Ray Peat many years ago and back in the beginning Ray Peat recommended magnesium way way more than calcium. Someone bought his website and is rewriting his articles. The people who run the forums in his name are not giving you true Ray Peat information.

Ray Peat did always recommend drinking orange juice and even eating ice cream, but he always recommended magnesium as a supplement. And magnesium is a calcium channel blocker, which helps the calcium go where it's supposed to go but not where it's not supposed to go.

Although when you think about calcium issues, it's not really the calcium, it's calcium metabolism. So if K2 is causing pain, it might be doing so because of it's power on calcium, but only calcium that is where it's not supposed to be or bound to something it's not supposed to be bound to. For it to be causing pain is very out of the ordinary, though, so the problem seems rather complicated.

I'm not saying magnesium is the answer, or that your husband doesn't need calcium, though. I truly don't know about that. I wonder if adding sodium bicarbonate to his orange juice might relieve the IBS-D, though.

 

[Gondwanaland]

Someone bought his website and is rewriting his articles.

:thumbdown:

The people who run the forums in his name are not giving you true Ray Peat information.

Of that I am aware

For it to be causing pain is very out of the ordinary, though, so the problem seems rather complicated.

Tell me about it!

I'm not saying magnesium is the answer, or that your husband doesn't need calcium, though. I truly don't know about that. I wonder if adding sodium bicarbonate to his orange juice might relieve the IBS-D, though.

Orange juice doesn't cause him IBS-D. The supplementes I give him do

We are having problems with magnesium on its own.

Magnesium lowers his blood pressure (sometimes gives him muscle twitches), I am going to keep his Mg supplementation at night only. Also he started taking Mg glycinate, but at certain point he seemed to get oxalate symptoms (severe IBS-D in his case), and then I found out about glycine converting to oxalates endogenously. Other local optios are aspartate or citrate. We have citrate at home now.

And I haven't been tolerating magnesium, it seems I reached a limit, my calves get stiff (not crampy) when I take it.

 

[Violeta]

I should say that articles being rewritten and this
www.RayPeat.com
©2006-14 Ray Peat
All Rights Reserved
makes me think his website was sold. The articles being written by someone else is quite obvious, but I suppose something besides being sold could have happened in 2006. I shouldn't jump to conclusions.

Well, people can get by without supplementing magnesium, too. But it does make you wonder why someone is so sensitive????

Orange juice of course does not contain uric acid, but for me at least, it does cause uric acid problems, does it do that for your husband. When I was having my uric acid problems, even tomato sauce caused joint pain to return. Can you handle orange juice?

 

[Gondwanaland]

Orange juice of course does not contain uric acid, but for me at least, it does cause uric acid problems, does it do that for your husband.

You mean joint pain? No it doesn't.

When I was having my uric acid problems, even tomato sauce caused joint pain to return. Can you handle orange juice?

But tomato is something else. It is a nightshade. Nightshades cause inflammation/leaky gut (solanin).
I handle OJ fine, but don't drink it very often. I have been drinking 1/2 squeezed lemon in a luke warm glass of water every morining for the citrate to flush out oxalates, with no detrimental effects. I am taking minerals daily (Se, Zn, Cu, Mn) to counter the chelation from the citrate.

 

[Gondwanaland]

I should say that articles being rewritten and this
www.RayPeat.com
©2006-14 Ray Peat
All Rights Reserved
makes me think his website was sold. The articles being written by someone else is quite obvious, but I suppose something besides being sold could have happened in 2006. I shouldn't jump to conclusions.

Are the original articles gone?

Sorry @mariovitali for the temporary thread hijacking

 

[Violeta]

Are the original articles gone?

Sorry @mariovitali for the temporary thread hijacking

No, they just seem to be changed. I had printed a couple of them out, I'll have to see if I still have them.

I was just going to apologize, too, mariovitali. Thanks for not complaining.


I should be focusing more on folded and unfolded proteins, and how to straighten the problem out.

 

[mariovitali]

@Gondwanaland

No worries and let us know how it goes!

 

[Gondwanaland]

@Gondwanaland

No worries and let us know how it goes!

DH surely is experiencing too much Ach and GABA while on Choline, P5P and Taurine
I am also giving him a little B complex, and some B2 (this one makes him depressed), but I think we will have to push through for at least a week of consistent supplementation.

 

[mariovitali]

DH surely is experiencing too much Ach and GABA while on Choline, P5P and Taurine
I am also giving him a little B complex, and some B2 (this one makes him depressed), but I think we will have to push through for at least a week of consistent supplementation.

Each one is different and each one of us have different holes that have to be filled in. I would not be eligible to take the correct steps (in terms of supplementation) if i didn't know my DNA and which problems i should address.

The same applies with your DH. Why does he experience Ach surge? Why does B2 makes him depressed?

One more question. Does he eat a lot of Protein (apart from the Whey Protein that he is taking)?