Unfolded Protein Response and A Possible Treatment for CFS

[mariovitali]

@Violeta

This is the list :

Note that DPAGT1 is gene for UDP-N-acetylglucosamine—dolichyl-phosphateN-acetylglucosaminephosphotransferase

Look here as well regarding DPAGT1: http://biograph.be/concept/show/C1414133

Notice also the other entries on the top such as caspases, acetylcholine, mast cell activation, trpv, etc.

ngf.csv are entries for Nerve Growth Factor. For any other clarifications, let me know.

*********Topic : tyrosine kinase ***************
ngf.csv : 4.29 %
mastocytosis.csv : 3.56 %
dpagt1.csv : 3.33 %
mast_cell_activation.csv : 3.28 %
neurite_outgrowth.csv : 2.84 %
caspase_human.csv : 1.18 %
histone_deacetylase.csv : 1.10 %
acetylcholine.csv : 0.95 %
endothelial_nos.csv : 0.86 %
inducible_nos.csv : 0.82 %
cyp3a4.csv : 0.81 %
curcumin.csv : 0.78 %
nlinkedglycosylation.csv : 0.77 %
phospholipid_human.csv : 0.74 %
rituximab.csv : 0.72 %
nadph_human.csv : 0.68 %
trpv.csv : 0.68 %
urea_cycle.csv : 0.68 %
heat_shock_protein.csv : 0.65 %
ros.csv : 0.65 %
star.csv : 0.62 %
glycoproteins.csv : 0.60 %
tocotrienol.csv : 0.59 %
insulin_resistance.csv : 0.59 %
tudca.csv : 0.57 %
peroxynitrite.csv : 0.54 %
excitotoxicity.csv : 0.52 %
rar.csv : 0.50 %
o-glcnac.csv : 0.50 %
er_stress.csv : 0.47 %
resveratrol.csv : 0.45 %
p450scc.csv : 0.43 %
hsp70.csv : 0.41 %
osmolytes.csv : 0.40 %
hepatotoxicity.csv : 0.40 %
rxr.csv : 0.38 %
steroidogenesis_human.csv : 0.38 %
glycosylation.csv : 0.37 %
hgh.csv : 0.37 %
pbmc.csv : 0.37 %
glutamate.csv : 0.37 %
udpgluc.csv : 0.36 %
sirt1.csv : 0.35 %
calcium_homeostasis.csv : 0.34 %
gtp_cyclohydrolase.csv : 0.33 %
subclinicalhypo.csv : 0.32 %
cyp1b1.csv : 0.32 %
inflammatory_response.csv : 0.31 %
neuronal_nos.csv : 0.30 %
human_proteinuria.csv : 0.29 %
cyp1a1.csv : 0.29 %
oxidative_stress_protection.csv : 0.29 %
butyrate.csv : 0.27 %
hexosamine.csv : 0.27 %
amyloid.csv : 0.26 %
upr.csv : 0.25 %
taurine.csv : 0.25 %
hmgcoa.csv : 0.25 %
mitochondrial_dysfunction.csv : 0.24 %
3betahsd.csv : 0.23 %
phosphatidylcholine.csv : 0.23 %
nadh_human.csv : 0.23 %
vitamin_d3.csv : 0.22 %
cyp1a2.csv : 0.21 %
p450oxidoreductase.csv : 0.21 %
tau.csv : 0.20 %
serotonin_levels.csv : 0.20 %
hydroxysteroid_dehydrogenase.csv : 0.19 %
advanced_glycation_end.csv : 0.19 %
dht.csv : 0.19 %
monosodium_glutamate.csv : 0.18 %
cyp2d6.csv : 0.17 %
n-acetylglucosamine.csv : 0.16 %
l_tyrosine.csv : 0.15 %
dopamine_levels.csv : 0.15 %
gaba_human.csv : 0.15 %
lipoic_acid.csv : 0.14 %
vitamin_k2.csv : 0.14 %
fmo3.csv : 0.13 %
asymmetric_dimethylarginine.csv : 0.13 %
triiodothyronine_levels.csv : 0.13 %
tetrahydrobiopterin.csv : 0.12 %
autism.csv : 0.12 %
choline_deficiency.csv : 0.12 %
misfolded_proteins.csv : 0.11 %
dopamine.csv : 0.11 %
omega3.csv : 0.11 %
freet3.csv : 0.11 %
acetyl-coa.csv : 0.11 %
tmao.csv : 0.10 %
udpglcnac.csv : 0.10 %
car.csv : 0.10 %
dihydroprogesterone.csv : 0.10 %
oxidative_stress_markers.csv : 0.09 %
magnesium_deficiency.csv : 0.09 %
l_tryptophan.csv : 0.09 %
pregnenolone.csv : 0.09 %
cyp2e1.csv : 0.09 %
uric_acid.csv : 0.09 %
ckd.csv : 0.09 %
l_carnitine.csv : 0.08 %
limbic_system.csv : 0.08 %
accutane.csv : 0.08 %
pxr.csv : 0.08 %
coenzymeq10.csv : 0.07 %
zinc_supplementation.csv : 0.06 %
creatine_supplementation.csv : 0.06 %
testosterone_production.csv : 0.06 %
cfs.csv : 0.06 %
adrenal_hyperplasia.csv : 0.06 %
ginkgo.csv : 0.06 %
dolichol.csv : 0.06 %
5-htp.csv : 0.06 %
sinusitis.csv : 0.05 %
allopregnanolone.csv : 0.05 %
systemic_amyloidosis.csv : 0.05 %
beta-alanine.csv : 0.05 %
l-dopa.csv : 0.04 %
steatohepatitis.csv : 0.04 %
adrenal_insufficiency.csv : 0.04 %
cholestasis.csv : 0.04 %
cortisol_levels.csv : 0.04 %
irritable_bowel.csv : 0.04 %
selenium.csv : 0.04 %
nafld.csv : 0.04 %
probiotics.csv : 0.03 %
dysautonomia.csv : 0.03 %
human_semen.csv : 0.03 %
gluten.csv : 0.03 %
amyloidosis.csv : 0.03 %
p5p.csv : 0.03 %
selenium_deficiency.csv : 0.03 %
5alphareductase.csv : 0.02 %
insomnia.csv : 0.02 %
sshl.csv : 0.02 %
atrial_fibrillation.csv : 0.02 %
mthfr.csv : 0.02 %
adhd.csv : 0.01 %
hpa_axis.csv : 0.01 %
microbiome_humans.csv : 0.01 %
tinnitus.csv : 0.01 %
panic_disorder.csv : 0.01 %
iron_deficiency.csv : 0.01 %
social_anxiety.csv : 0.00 %
scfa.csv : 0.00 %
5mthf.csv : 0.00 %
pgc1.csv : 0.00 %
phenylketonuria.csv : 0.00 %
orthostatic_intolerance.csv : 0.00 %
cerebrovascular_amyloidosis.csv : 0.00 %
oxalates.csv : 0.00 %
finasteride.csv : 0.00 %
benfotiamine.csv : 0.00 %
pqq.csv : 0.00 %
mucuna.csv : 0.00 %
vitamin_b6.csv : 0.00 %
floaters.csv : 0.00 %
d-limonene.csv : 0.00 %
resistant_starch.csv : 0.00 %
srd5a3.csv : 0.00 %

 

[mariovitali]

I started the taurine about 10 days ago, and was having some interesting digestive reactions that I figured were from it increasing bile flow. I can't remember how much I was taking, either 1/8th or 1/4 tsp in some water. Yesterday and today I took 1/4 tsp with the 1/4 tsp of beta alanine.

The only thing I can think of that might relieve the oxalate dump is either baking soda or borax.

FYI Taurine is an osmolyte too.

@mariovitali What do you suppose all the uric acid has to do with this?

[uric_acid, n-acetylglucosamine]: 70 ==> [choline_deficiency]: 70 <conf (1)> lift (2.19) lev (0.15) conv (38.08)
[uric_acid, misfolded_proteins]: 67 ==> [choline_deficiency]: 67 <conf (1)> lift (2.19) lev (0.14) conv (36.45)
[uric_acid, dolichol]: 66 ==> [choline_deficiency]: 66 <conf (1)> lift (2.19) lev (0.14) conv (35.91)
[n-acetylglucosamine, l_carnitine]: 75 ==> [choline_deficiency]: 75 <conf (1)> lift (2.19) lev (0.16) conv (40.8)
[n-acetylglucosamine, selenium_deficiency]: 72 ==> [choline_deficiency]: 72 <conf (1)> lift (2.19) lev (0.15) conv (39.17)
[n-acetylglucosamine, pqq]: 67 ==> [choline_deficiency]: 67 <conf (1)> lift (2.19) lev (0.14) conv (36.45)

The tool finds possible indirect relationships and this is what you see here. In other words, the tool suggests that there might be an indirect relationship between uric acid and n-acetylglucosamine

 

[mariovitali]

@Gondwanaland

Sorry if i ask again, have you tried Taurine for your Oxalate levels?

Normalization of urinary oxalate by taurine in glycolate-fed rats.
Talwar HS, Madiraju VS, Murthy SR, Nath R, Thind SK.
Abstract
Oral feeding of sodium glycolate (50 mg/d/rat for ten days) caused a significant (P less than 0.001) increase in oxalate and taurine excretion and a decrease in liver protein content (P less than 0.05), glycolic acid oxidase levels (P less than 0.01), and glycolic acid dehydrogenase levels (P less than 0.01) as compared to normal untreated rats. Taurine (100 mg/d/rat), when administered along with glycolate, prevented these effects of glycolate as evident from normal urinary excretion of oxalate, liver protein content, glycolic acid oxidase, and glycolic acid dehydrogenase levels in glycolate- plus taurine-fed animals.



and



Abstract
It has been suggested that, because of bile-salt malabsorption, patients with ileal dysfunction " spill " glycine-conjugated bile-salts into their large bowel. There, colonic bacteria deconjugate the bile-salts and convert the liberated glycine to glyoxalate, which in turn is absorbed, oxidised in the liver to oxalic acid, and excreted in the urine to produce hyperoxaluria and, occasionally, oxalate renal stones. To test this hypothesis, urinary oxalate excretion was measured in eleven patients with ileal dysfunction, and eight of these showed severe hyperoxaluria ranging from 91 to 202 mg. per 24 hours (normal <35 mg. per 24 hours). Three patients had had urinary calculi. In one patient the stone was analysed by X-ray diffraction studies and was shown to be calcium oxalate monohydrate. In a second patient, chemical analysis of calculi removed on two separate occasions again showed that these were calcium-oxalate stones. Since taurine feeding changes the glycine/ taurine bile-salt ratio in favour of taurine, this aminoacid was fed to one hyperoxaluric patient in an attempt to remove this substrate for oxalate formation. 9 g. of taurine per day by mouth promptly abolished this patient's hyperoxaluria.

 

[Gondwanaland]

Sorry if i ask again, have you tried Taurine for your Oxalate levels?

Last year when I tried it couldn't tolerate it: just couldn't keep my eyes open, very strange, not sleepy, but the eyes!!!

And then insomnia at night.

Perhaps now I am a step ahead in detoxing, so will re-try it again soon

 

[mariovitali]

Last year when I tried it couldn't tolerate it: just couldn't keep my eyes open, very strange, not sleepy, but the eyes!!!

And then insomnia at night.

Perhaps now I am a step ahead in detoxing, so will re-try it again soon

Great. B6 is good for low oxalates too, just make sure you are taking the correct form for your SNPs

 

[Gondwanaland]

there might be an indirect relationship between uric acid and n-acetylglucosamine

I am about to try NAG, and have high-ish uric acid. Does it raise or decrease it?

 

[Gondwanaland]

Great. B6 is good for low oxalates too, just make sure you are taking the correct form for your SNPs

I thought P5P was the best form for anyone , or at least for keeping my zinc supplementation low

 

[mariovitali]

@Gondwanaland

My husband takes glucosamine supplements to treat gout. But I'm wondering if glucosamine, which contains shellfish, may actually worsen gout symptoms?

Taking glucosamine isn't likely to have any effect on gout — either good or bad.

Gout is a form of arthritis that's characterized by sudden, severe attacks of pain, redness and tenderness in joints. Gout is caused by deposits of uric acid crystals in a joint. Uric acid is a waste product formed from the breakdown of purines — substances found naturally in the body and in certain foods, including shellfish and organ meats.

Typically, glucosamine is made synthetically or from the outer shells (exoskeletons) of shellfish — not from shellfish meat. Because glucosamine doesn't contain purines, it isn't likely to increase uric acid levels or aggravate gout symptoms. Likewise, there's no clinical evidence that glucosamine helps prevent or treat gout either.

 

[Gondwanaland]

I think my reaction to Taurine has something to do with low B2, because this morning I skipped my B2 and am feeling like I took taurine

If the high purines were the only problem with uric acid it would be easier to manage Frutose impairs the elimination of uric acid... But right now I am working with the hypothesis that my underlying problem is oxalate. I believe I read somewhere it also interacts negatively with uric acid.

 

[Violeta]

I've read the study that is used in many articles to say that fructose causes gout by raising uric acid levels, and the study isn't being interpreted correctly. If you read down to the bottom you will see that fructose causes release of uric acid from tissue dependant on predosing with uric acid. So the fructose is actually causing uric acid stores to be released from cells. This may not be good if your blood is already in an acidic state, but if you get yourself alkalized and start to remove the uric acid from your cells it helps with overall health.

Just possibly one more reason to do that protein recycling diet mentioned earlier.

 

[Violeta]

@Violeta

This is the list :

Note that DPAGT1 is gene for UDP-N-acetylglucosamine—dolichyl-phosphateN-acetylglucosaminephosphotransferase

Look here as well regarding DPAGT1: http://biograph.be/concept/show/C1414133

Notice also the other entries on teh top such as caspases, acetylcholine, mast cell activation, trpv, etc.

ngf.csv are entries for Nerve Growth Factor. For any other clarifications, let me know.

Thank you so much. That tool is very helpful if you can't figure out how to direct your google search! I guess I have a lot of reading to do!

Have you tried tyrosine supplementation(raises dopamine, lowers serotonin)? Sorry if it's mentioned in the thread, I searched the thread but didn't find it, and I'm reading though it as fast as I can.

 

[mariovitali]

@Violeta,

I have a GCH1 mutation which impairs BH4 production (and as a consequence Dopamine and Serotonin). I am not sure about this but Tyrosine made me feel a bit "edgy".

I might try it again.

 

[Violeta]

@Violeta,

I have a GCH1 mutation which impairs BH4 production (and as a consequence Dopamine and Serotonin). I am not sure about this but Tyrosine made me feel a bit "edgy".

I might try it again.

Neurotransmitters are very tricky. I see it can lowers serotonin. I don't know where I stand with respect to dopamine and serotonin, but I do have a lot of tyrosine deficiency symptoms. I will look it up with respect to some of the other hits that you provided. I was just thinking how complicated this all is. Congratulations for getting yourself so much better!

 

[Violeta]

First thing I am looking up with respect to tyrosine kinase is it's inhibitors. Sometimes they are helpful and sometimes not. Two natural ones are green tea and soy. If one is low in conversion of t4 to t3, avoiding tyrosine kinase inhibitors would be a good thing. So I can see why green tea isn't good for everyone. That would naturally lead to looking up estrogen and it's tie in, for which there are a lot of hits.

 

[Violeta]

Maybe I'm crazy, but everything I look at seems to take me back to calcium channels, which brings me back to k2.
Too bad natto tastes so terrible, it's the perfect combination, k2 and nattokinase.

 

[mariovitali]

Maybe I'm crazy, but everything I look at seems to take me back to calcium channels, which brings me back to k2.
Too bad natto tastes so terrible, it's the perfect combination, k2 and nattokinase.

Why don't you take Vitamin K2 tablets instead?

 

[Violeta]

Why don't you take Vitamin K2 tablets instead?

Yeah, I do. I have Thorne liquid, too.

 

[Gondwanaland]

Just possibly one more reason to do that protein recycling diet mentioned earlier.

Please refresh my memory... What is the diet? I am concerned with my husband whose serum creatinine is on the high side, and obviously he has been avoiding proteins, and is eating pizza too many times in a week. His triglycerids and insulin are sky high

which brings me back to k2.

Yeah... I wonder when I will tolerate it... A few days ago I gave DH one drop of Thorne D3 500mcg /K2 100mcg and his back pain came back We need a strategy to take K2.

 

[Violeta]

Please refresh my memory... What is the diet? I am concerned with my husband whose serum creatinine is on the high side, and obviously he has been avoiding proteins, and is eating pizza too many times in a week. His triglycerids and insulin are sky high

Yeah... I wonder when I will tolerate it... A few days ago I gave DH one drop of Thorne D3 500mcg /K2 100mcg and his back pain came back We need a strategy to take K2.

Here's the link to the protein cycling diet. But it might not be necessary to go that far.
https://proteincyclingdiet.wordpress.com/article/protein-cycling-diet-2s3nmvrwklbxs-1/

Ha! That's my husband's kind of diet, for sure. I worry about my husband's insulin, too. I don't know the answer to a diet to correct the creatinine and then keep triglycerides and insulin down, too. Well, I guess that would be a diet high in vegetables.

I wonder if vitamin K2 by itself would work? One drop, though! Wow! What type of pain comes back when he takes the D3 and K2?

 

[Gondwanaland]

I wonder if vitamin K2 by itself would work? One drop, though! Wow! What type of pain comes back when he takes the D3 and K2?

I think it is his herniated disk.