Thymosin Alpha 1

Learner1

Senior Member
Messages
6,311
Location
Pacific Northwest
Do you have information from the doctor after how long it should be clear whether the peptide works for us?
The reason it was prescribed for me is that I am immunodeficient, and the hope is it will help give me more of a defense in case I come in contact with COVID-19.

I think I will be on it for several months, but it will depend on how my immune system changes in the next few months.

As with any of this, there are no guarantees.
 

MartinK

Senior Member
Messages
388
Hey all peptides users, really bad news here! :-/
Sorry for this bad vibe...
But I had to stop everything! Huge, really huge PEM, inflammation, body pain and kidney pain after 2 weeks on peptides.

I guess I started too big doses! :-/ Semax 500mcg/day, TA1 + TB4 1500mcg 2xweek at same time.
And Im stupid, because in same time I start higher dose of Cromolyn (Nalcrom) and also Huperzine A 200mg/day.

This was hard knock-out.

Anyone with same side effects to peptides? PEMs?

I hid everything in the freezer for longer stamina and start one by one when I recover...maybe from May and slowly.

Martin
 

MartinK

Senior Member
Messages
388
@sb4 yes, now really hard to tell. Did you try also Mestinon except Huperzine?

Im trying to find what type of patients responds poorly and bad to peptides.

Im post-Lyme, post-EBV, post-Varicella Zoster patient with MTHFR and probably MCAS.
but I had no rash from the peptides on place of application...
I think my CFS causes inflammation and immune system.

I'm thinking about a specialist's contact over peptides but I don't know anybody here in Europe...
 

sb4

Senior Member
Messages
1,802
Location
United Kingdom
@sb4 yes, now really hard to tell. Did you try also Mestinon except Huperzine?

Im trying to find what type of patients responds poorly and bad to peptides.

Im post-Lyme, post-EBV, post-Varicella Zoster patient with MTHFR and probably MCAS.
but I had no rash from the peptides on place of application...
I think my CFS causes inflammation and immune system.

I'm thinking about a specialist's contact over peptides but I don't know anybody here in Europe...
I did try mestonin but only once I think, it immediately made my heart pounding worse so I decided against it. I tried epitalon, Thymosin A, and B4 but I didn't notice anything from any of them.
 
Messages
22
Hey all peptides users, really bad news here! :-/
Sorry for this bad vibe...
But I had to stop everything! Huge, really huge PEM, inflammation, body pain and kidney pain after 2 weeks on peptides.

I guess I started too big doses! :-/ Semax 500mcg/day, TA1 + TB4 1500mcg 2xweek at same time.
And Im stupid, because in same time I start higher dose of Cromolyn (Nalcrom) and also Huperzine A 200mg/day.

This was hard knock-out.

Anyone with same side effects to peptides? PEMs?

I hid everything in the freezer for longer stamina and start one by one when I recover...maybe from May and slowly.

Martin

Hi @MartinK, I had a similar experience with TA1. I took 1500mcg of TA1 twice a week. The first week I did not notice any difference. The second week I felt fantastic (the best I've felt since I came down with ME/CFS in 2011). Then exactly at two weeks, I began to develop flu-like symptoms (joint and muscle aches, total exhaustion) that got worse as I stayed on the TA1.

I spoke with the physician who prescribed the TA1, and we both think the dose was too high. He also regularly prescribes TA1 and said this reaction was uncommon (most people either benefit, or at worst find no effect). I'm curious about trying TA1 in the future at a lower dose, and knowing to stop immediately if there is any symptom worsening, but have been putting this off since I'm a bit scared after the first time tbh.

Are you planning to try the peptides again in the future? Would you take the same dose or change it?
 

MartinK

Senior Member
Messages
388
hey @emmers it's great that you have a doctor who understands peptides!
I tried a lot here find some help, some recommendation to peptide-known doctor but without answers or personal messages.

It is a real pity, because here in my country there is no doctor with peptides experience...or better yet peptides for CFS patient.

Yes, looks like my doses was really big from start, same problem like you...
Now I'm trying to stabilize. I'm afraid of peptides without expert consultation now...

I think I overstimulated my immune system and maybe it worsened MCAS or the autoimmune response :-/
 

Learner1

Senior Member
Messages
6,311
Location
Pacific Northwest
hey @emmers it's great that you have a doctor who understands peptides!
I tried a lot here find some help, some recommendation to peptide-known doctor but without answers or personal messages.

It is a real pity, because here in my country there is no doctor with peptides experience...or better yet peptides for CFS patient.

Yes, looks like my doses was really big from start, same problem like you...
Now I'm trying to stabilize. I'm afraid of peptides without expert consultation now...

I think I overstimulated my immune system and maybe it worsened MCAS or the autoimmune response :-/
Hi there,

Sorry just noticed this now. That's a lot of powerful stuff to be trying at one time. Your idea of over stimulating your immune system sounds about right.

Can you somehow unwind all of this, and maybe go back to restarting one thing at a time?

From what I understand, thymus and alpha is supposed to kind of help an older thymus gland to make more T cells. could it be which T cells are being stimulated and what they're doing? Is it at all possible that they could be stimulating some T cell mediated autoimmune problem? I really don't know, just throwing some thoughts out there. Have you or your doctor tried communicating with whoever sold you the thymosin alpha? If you are interested, you can PM me and I will give you my doctors' information, perhaps your doctor can communicate with one of them..

Ask for Hooper z A, it supposedly has a similar effect to Mestinon, and that is to increase the acetylcholine that's available. I first learned about acetylcholine with my mother's Parkinson's, and saw her do some extremely strange things, hallucinations, etc., on an acetylcholine inhibitor. It gave me a great respect for acetylcholine, and too much or too little can really screw you up. I found Mestinon gave me very difficult intestinal symptoms, but the neostigmine and Huperzine A both help me without the bad symptoms. Neostigmine had about a 4-hour half-life, and I believe the Huperzinee has about a 12 or 13-hour half-life. I take 200 mg of Huperzine A, maybe you don't need that much, although that's the standard dose for Alzheimer's.

I also take phosphatidylcholine, and NT Factor, both of which can increase acetylcholine eventually. I know that my body needs all this, again maybe your body is not quite as needy.

Another area to look into might be calming the inflammasome. just a general concept, but you might look into the various things that can calm inflammation, like:
  • Vitamin A, C, D, E
  • NAC, glutathione
  • Potassium, zinc
  • Melatonin
  • Curcumin, quercetin, nigella, baicalin, resveratrol, astragalus, andrographis, reishi, echinacea, goldenseal
Obviously this is a pretty long list, perhaps there's some combination of things that you really need, that would really benefit you.

Best wishes
 
Messages
56
I can't get any more peptides from Tailor Made or anywhere in the USA except for Thymosin Alpha because the bureaucracy in charge of these things has now banned production of them in the US. Does anyone know where MOTS-c could still be gotten?
thank you <3
 

BenFromNZ

Senior Member
Messages
151
Hey all peptides users, really bad news here! :-/
Sorry for this bad vibe...
But I had to stop everything! Huge, really huge PEM, inflammation, body pain and kidney pain after 2 weeks on peptides.

I guess I started too big doses! :-/ Semax 500mcg/day, TA1 + TB4 1500mcg 2xweek at same time.
And Im stupid, because in same time I start higher dose of Cromolyn (Nalcrom) and also Huperzine A 200mg/day.

This was hard knock-out.

Anyone with same side effects to peptides? PEMs?

I hid everything in the freezer for longer stamina and start one by one when I recover...maybe from May and slowly.

Martin
I'll be trying TA-1 again soon. But based on my previous experience it will be at way lower doses than physicians usually prescribe. Even 150mcg a day was too much for me (knocked me back after about a week of daily doses) . Some of our symptoms are just so sensitive. I beleive I will be ok at 30mcg-50 mcg daily (without it giving negative affects building up over time) I THINK I might have had some benefits when I was cautiously trying it at that dose previously, but when I ramped up to 100-150mcg I ran into setbacks.
 

BenFromNZ

Senior Member
Messages
151
I can't get any more peptides from Tailor Made or anywhere in the USA except for Thymosin Alpha because the bureaucracy in charge of these things has now banned production of them in the US. Does anyone know where MOTS-c could still be gotten?
thank you <3

Should be able to get it from canlab:

https://www.canlab.net/product-page/mots-c-5mg-human-sequence

Peptide science also still has it:

https://www.peptidesciences.com/mots-c-10mg

Not sure if limitlesslifenootropics will get back in stock soon or not but they usually sell it:

https://www.limitlesslifenootropics.com/shop/mots-c-5mg-98/
 
Last edited:

ChookityPop

Senior Member
Messages
605

Learner1

Senior Member
Messages
6,311
Location
Pacific Northwest
Melatonin is cheap, legal, and easily available in the US, and a natural substance. I took 30mg daily during my cancer treatment, prescribed by my doctors. It looks to be helpful for COVID defense. It helps reduce oxidative stress in mitos.

Epithalon does look interesting, and has some similar properties to melatonin, but it is more expensive and harder to acquire. And though the quick research I've done says it may have benefits in certain cancers, as a stage 3 cancer survivor, I've found that found like this tend to be worth researching thoroughly to uncover any potential risks. Though ME/CFS can be dismal, cancer can be worse.
 

ChookityPop

Senior Member
Messages
605
Melatonin is cheap, legal, and easily available in the US, and a natural substance. I took 30mg daily during my cancer treatment, prescribed by my doctors. It looks to be helpful for COVID defense. It helps reduce oxidative stress in mitos.

Epithalon does look interesting, and has some similar properties to melatonin, but it is more expensive and harder to acquire. And though the quick research I've done says it may have benefits in certain cancers, as a stage 3 cancer survivor, I've found that found like this tend to be worth researching thoroughly to uncover any potential risks. Though ME/CFS can be dismal, cancer can be worse.
Thanks for your input, I appreciate it! You are a warrior my friend! I will read more about it and call my doctor tomorrow and get it.
 
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