Sam7777
Senior Member
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Yes, the FMN is helping a lot. My eyes were actually worse for a couple of days, though. That happened when I started taking the B2, too, though.
The Source Naturals R-5'-P tastes terrible, I may try Douglas Labs next. A whole cap of Douglas Labs is only 10mg?
I should probably start trying to take some niacin, too.
I don't understand the whole thioredoxin, thioredoxin reductase, NADPH thing either. I just keep reading and then sooner or later it breaks through.
This paper says that selenium can be a limiting factor, too. I know I'm terribly deficient in selenium, and that might be why I was so mercury toxic. Either that, or visa versa. But I think we talked about this before.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220815/
PS: Good for you that you can handle eggs and swiss chard!
Of course I do -- I'm hypothyroid. I've tracked my temps often, and before starting T3, I was usually in the 96 to low 97 range. Now I'm usually in the 98.0 - 99.0 range.Does anyone else tend towards low body temp?
Of course I do -- I'm hypothyroid. I've tracked my temps often, and before starting T3, I was usually in the 96 to low 97 range. Now I'm usually in the 98.0 - 99.0 range.
You've already identified isothiocyanates as a problem. Have you had a look at the whole category of goitrogens? That sounds like the culprit, rather than thiols in general. You could always try an experiment, and drop the cruciferous vegetables, while continuing with the egg.
Are you doing a thyroid treatment of any kind?
BTW, my thyroid function did not improve on dessicated pig thyroid; I had to take T3-only to get any improvement. That's what happens if you have a problem converting T4 to T3. Many of us at PR have low glutathione levels, and glutathione is needed for that conversion.
Actually, selenium and iodine together is a thyroid treatment recommended by Dr. David Brownstein. You don't need a prescription for either one. But look at Brownstein's recommendations before you try it. Guy Abraham is another doc to read on iodine.No, no thyroid treatment.
Why those, do you think? (I wouldn't dare try anything with as many ingredients as Clear Way Cofactors.)I'm thinking that the herbs in clear way cofactors that are effective are mainly the bacopa, gotu kola, but especially the triphala.
Actually, selenium and iodine together is a thyroid treatment recommended by Dr. David Brownstein. You don't need a prescription for either one. But look at Brownstein's recommendations before you try it. Guy Abraham is another doc to read on iodine.
Iodine can pull toxic halides (fluoride, bromide, perchlorate) out of the tissues. We had perchlorate (rocket fuel) in our drinking water when I was a kid. Iodine is the only thing that can detox perchlorate from the body. But depending on your level of exposure, it may be wise to go slowly!
That's the one I would use, and just delete all the goitrogens and anything else you don't tolerate. It's just an experiment I thought of, to see whether thiols really are a problem for you.Would this list of foods high in thiols be adequate?
http://www.livingnetwork.co.za/chelationnetwork/food/high-sulfur-sulphur-food-list/
Which of the things on the list bother you? Does one have to be bothered by all of them to have a problem with thiols?That's the one I would use, and just delete all the goitrogens and anything else you don't tolerate. It's just an experiment I thought of, to see whether thiols really are a problem for you.
Overall, mercury inhibition was selective toward the thioredoxin system. In particular, the remarkable potency of the mercury compounds to bind to the selenol-thiol in the active site of TrxR should be a major molecular mechanism of mercury toxicity.
Selenols (–SeH) have a lower pKa than thiols (5.3 versus 8.5) and under physiological conditions are fully ionized to selenolates (–Se−) and thus are more reactive and can easily interact with mercury [28]. Selenoenzymes such as glutathione peroxidases (GPxs) are good targets for mercury [29–32] but, recently [28], the involvement of the thioredoxin system – comprising thioredoxin (Trx), the selenoenzyme thioredoxin reductase (TrxR) and NADPH – in the molecular mechanism of mercury toxicity was proven. The inhibitory effects of mercurials on the thioredoxin system have been shown both in vitro [28, 33] and in vivo [4, 34, 35]. Thioredoxin reductase is particularly sensitive to mercurials which results from its highly nucleophylic structure.