@Martin aka paused||M.E.
Thanks for posting the article and videos. Very interesting. I note the FDA went after a NAD+ manufacturer recently for advertising it as a COVID treatment...
One thing that I didn't see discussed was that any form of niacin can reverse methylation, so might be wise to take some methylfolate, MB12 and co-factors if one tries this. I also don't see why taking NAD+ or NMN are not recommend. If it's a shortage of NAD+ they directly raise NAD+ levels and help SIRT1, and can recycle into other forms of niacin in the body. The one I wouldn't recommend is NR. Itvtahes too many steps to convert sndcforsnt work at all on folks with certain fairly common genetic mutations.
Trimethylglycine seems to be important too for avoiding methylation issues, I didn't do so well on NR without it.
it's because it reverses methylation. TMG provides methyl groups. I suspect raising folate, MB12 and co-factors would help, too.
I don't understand why anyone would take niacin for mast cell activation syndrome, like that doctor in the article treats it with. I mean... It's the opposite. So I want to understand. I avoid niacin because I have mcas and it is completely dangerous for those with severe enough mcas where anaphylaxis might follow from a large amount of histamine, and inappropriate for those with moderate like me, but... what's the logic? Is it being suggested that one "push through" the symptoms from niacin in order to receive a significant benefit for mast cell activation?
I have MCAS and have had no problem at all with mast cells taking NR, NADH, NAD+, or NMN. Why do you think they'd a problem?
I stay away from niacin as I do well with NMN or NR, and don't need the flushing or to reduce methyl groups.
I'd like to know the relationship of NAD+ injections to mast cell activation as well. The author says that for the purposes of helping covid and long covid that it's nicotinamide that serves that purpose, not the other forms, some of which can be problematic (in general or for this? I don't know). But I'm just curious about NAD+ injections to see if they might be usable for me for low seratonin issues. If anyone has a theory of how nicotinamide would possibly assist instead of worsen mcas or the relationship of the nac+ form to mast cell activation, would love to hear. Again, it is dangerous in the case of severe mcas.
With severe MCAS, it would be wise to improve gut health, to treat any oxalate problems, and to be on a full spectrum of mast cell support - quercetin, curcumin, cromolyn sodium, H1 and H2 antihistamines, imatinib, etc.
Ive had several NAD IVs and would definitely not recommend them for anyone with severe MCAS. They are the harshest IV I've done, upsetting my stomach, causing diarrhea and severe headache and pain in my forearms. The aftereffects were fantastic, lasting 36 hours, but there's a risk vs benefit decision. I find using sublingual NMN or NAD+ to be much easier tolerated and controlled. There are tablets that can be made smaller, powder, and nasal spray that might be better options - they don't set off my mast cells.
I tried that protocol when it came out in November and nothing of note. The selenium made me feel worse and everything else was no impact.
I'm on something similar, individualized for my needs. Each of us has different biochemistry, do you may need more or less of things than others. Fir example, I need 3g a day of vitamin C, taken in 2g doses, and 60mg zinc picolinate a day.
Selenium is used for 2 important things in addition to others. It's important for the thyroid:
"Selenium and Your Thyroid: What You Should Know" https://www.verywellhealth.com/selenium-and-your-thyroid-4134998
And, it's needed to make glutathione. Making more glutathione can mobilize toxins like heavy metals, mycotoxins, etc. which can make you feel pretty bad if your transsulfuration pathway doesn't have enough B2 and molybdenum to flush them out.