"The Secrets of COVID `Brain Fog' are Starting to LIft" WIRED Jul 1, 2022

[L'engle]

BTW, potatoes and tomatoes make my ME symptoms worse, so I'm definitely not willing to experiment with chewing on tomato plants.

In my experience nightshades can mess with electrolytes. I generally avoid them in all but small quantities.

 

[Alvin2]

I found this paper which says blackcurrant anthocyanins suppress CCL11 secretion. For those in the UK, perhaps drinking lots of the blackcurrant drink Ribena might be beneficial.

What?

I have three bottles of Ribena, its available in most grocery stores around here (Canada).
I save it for special occasions since its expensive (for me, being pathetically poor).
I'm going to go have some.

Any idea if this would cross the blood brain barrier?
Also a quick search has found this, might be doable for regular intake
https://www.healthyplanetcanada.com/crofter-s-organic-just-fruit-spread-black-currant-235ml.html

 

[BrightCandle]

I tried the blackcurrent supplements, did nothing of note.

 

[Alvin2]

I tried the blackcurrent supplements, did nothing of note.

Good to know, but disappointing
I'm going to take a glass of Ribena a day and see what happens during the next week.
Since it won't cost me anything i have little to lose and i get to enjoy one of my favourite juices

No idea if i have the dose right, what the half life is, if its standardized, if it crosses the blood brain barrier or not, but its delicious and low risk

 

[Hip]

What?

I have three bottles of Ribena, its available in most grocery stores around here (Canada).
I save it for special occasions since its expensive (for me, being pathetically poor).
I'm going to go have some.

Any idea if this would cross the blood brain barrier?
Also a quick search has found this, might be doable for regular intake
https://www.healthyplanetcanada.com/crofter-s-organic-just-fruit-spread-black-currant-235ml.html

Google says anthocyanins can cross the blood-brain barrier.

 

[Violeta]

This is so interesting, my fatigue has been much worse since having COVID at the end of June. In the USA, lingonberries or aronia berries would probably work.

You can get good quality lingonberry jam. Let me see if sour cherries would be good, too. Aronia berry products are mostly in powder form. Some are better than others, some are more expensive than others.

Oops, aronia and lingonberries are high in oxalates.

 

[Violeta]

A tangent that I'm thinking as a result of someone's comment is that microglia can be affected by peroxynitrite, too, and

what made me look that up is that Martin Pall recommends aronia berries for helping with the oxidative stress that causes peroxynitrite.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174990/

Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

My brain isn't working right atm, so I will come back and do clean up on this post later. But if this tangent is wrong or doesn't belong here, let me know.

 

[Rufous McKinney]

I tried the blackcurrent supplements, did nothing of note.

I am now unable to stop laughing, because I had entirely already forgotten this black current cure. 27 days later.

Cycling back here, Oh yes, I wanted to try black currents!

that will fix it.

 

[Rufous McKinney]

ligonberry jam

its lingonberry

I'm working on my tedious pendant Girl Scout Badge.

No, actually I forgot there was such a berry, and got thrown by the fact that LIGON is a family name of mine, thats quite uncommon. With many spellings.

Made me wonder if my GGreats discovered this berry.

but its LINGON

 

[Violeta]

I am now unable to stop laughing, because I had entirely already forgotten this black current cure. 27 days later.

Cycling back here, Oh yes, I wanted to try black currents!

that will fix it.

I often do that. As a matter of fact, I will come here looking for something, put it in the search, find an interesting post, and then realize I wrote it.

 

[Rufous McKinney]

put it in the search, find an interesting post, and then realize I wrote it.

 

[YippeeKi YOW !!]

I'm working on my tedious pendant Girl Scout Badge.

It's not bad enough that you're going after my job as Official Tedious Site Pedant, but NOW you want the title, too ??!?!?!???? WTF !!?!?!?!???

 

[Rufous McKinney]

It's not bad enough that you're going after my job as Official Tedious Site Pedant, but NOW you want the title, too ??!?!?!???? WTF !!?!?!?!???

mars is retrograde, maybe, or some other excuse, very temporary!

I had to verify Ligonberries.

 

[Rufous McKinney]

but NOW you want the title, too

I really don't wish to compete for your well earned title, and finely honed skill. But maybe it just happened again, over in the music thread- are these two different songs with the same name?

EGAD save me.

 

[YippeeKi YOW !!]

I really don't wish to compete for your well earned title,

"Well earned"????

Are you being snidely with me on top of everything else? Is there no justice ???

EGAD save me.

Sorry, no my yob.

Please apply to the appropriate govt office .... or better yet and for an even longer wait, write to your congress person

 

[heapsreal]

A tangent that I'm thinking as a result of someone's comment is that microglia can be affected by peroxynitrite, too, and

Could be why occasionally b12 injections can have a brain fog clearing effect within an hr or so but it is very hit and miss.

 

[heapsreal]

Hasn't been mentioned in this thread but valcyte was once mentioned to inhibit microglia cells, but I guess was the microclia because of a herpes virus??? Maybe it was Dr Montoya? I can't recall the name but someone from pr use to use microdoses of valcyte and get good improvements from it.

My last stint on valcyte this year, fog/headaches cleared up quite quickly but not sustainable once I finished 3 months of valcyte.
But no idea if it's indirectly treating microglia by treating viruses or directly hitting microglia.

 

[Alvin2]

Google says anthocyanins can cross the blood-brain barrier.

Excellent!

We shall see if one glass a day for a week or however long the bottle lasts does anything for me.

 

[heapsreal]

Hasn't been mentioned in this thread but valcyte was once mentioned to inhibit microglia cells, but I guess was the microclia because of a herpes virus??? Maybe it was Dr Montoya? I can't recall the name but someone from pr use to use microdoses of valcyte and get good improvements from it.

My last stint on valcyte this year, fog/headaches cleared up quite quickly but not sustainable once I finished 3 months of valcyte.
But no idea if it's indirectly treating microglia by treating viruses or directly hitting microglia.

Sorry, memories are coming through the fog, azithromycin was another treatment used for its anti inflammatory effects on the brain not unlike valcyte but success from studies weren't great.

 

[pattismith]

This brain fog research by researchers Michelle Monje and Akiko Iwasaki sounds interesting. So excerpts:

It seems that in brain fog, specialized microglia in the white matter may have become permanently switched on:

The factor that is switching on these microglia appears to be CCL11:

Interestingly, CCL11 was found elevated in the brains of ME/CFS too, in this study.

Minocycline?

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis | Virology Journal | Full Text (biomedcentral.com)