Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To register, simply click the Register button at the top right.
Does all this mean the brain fog is caused by a virus in the brain and we have to figure out on our own how to clear out the virus so that it doesn't activate CCL11?
No, it means that the immune response may have been activated by a virus--in the brain or elsewhere, or by some other immunogen--but for some reason the immune system stays locked in that state, even after the trigger is gone.
I believe that reducing viral infections can reduce some of the ME symptoms, but in general won't eliminate them permanently.
I've been beefing up my antioxidant anthocyanin consumption....(at least purple food is ripe and in season presently)...and more Omega 3s...
I think its helping me some.
I've been eating about a pint of blueberries a day for 5 days now and I am seeing a huge improvement. This morning I was able to read longer paragraphs in medical studies than usual.
As my body can't create vitamin D i have to take a high dose for life (on medical advice) and its tested regularly, i now have a fairly high level and yet my cognition is continuing to deteriorateWhat do you think about this study by Martin Pall? Do you think what he's talking about would affect microglia?
Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?
Chronic NF-κB activation has been supposed as a key event in chronic fatigue syndrome (CFS) and many other better-defined pro-inflammatory diseases. Knowledge about the impact of deficiency vitamin D on chronic NF-κB activation could open a new disease approach.
Whereas NF-κB activation leads at first to a pro-inflammatory immune response, later on a vitamin D-dependent anti-inflammatory response ensues.
Binding of the active vitamin D metabolite 1,25(OH)2D3 to vitamin D receptor (VDR) yields a transcription factor which represses NF-κB activation, and additionally modulates and down-regulates adaptive, but enhances innate immune responses, and improves redox balance, thus counterbalancing inflammation on multiple levels.
However, this built-in late counterbalance against inflammation works only when stores of calcium and 25(OH)D3 are abundant.
Therefore a connection between lowered vitamin D-metabolism and persistent NF-κB activation, augmented nitrosative-oxidative stress, redox imbalance, chronic inflammation, and concomitant fatigue can be postulated.
Did you see that one person in this thread said that antivirals relieve symptoms of brain fog?
But do antivirals relieve symptoms for the majority of PWME? If not, then it's an individualistic response and not THE ANSWER to ME. Cumin worked really well for me, but isn't the answer for anyone else.
Someone might benefit from eliminating one specific virus, but still have extra symptoms due to some other virus or other microbial infection. Also, actually eliminating a specific virus can be difficult and expensive, risky due to side-effects, and not guaranteed to succeed. If you knew for sure that you had a specific virus and the treatment was $100k and guaranteed to work and would improve your physical capacity by 12%, you could make an informed decision. Blindly taking expensive antivirals seems like a poor gamble.
My point is that this is reversible, but we will most likely have to figure out how on our own.
A New Zealand blackcurrant supplement called CurraNZ which has 35% anthocyanins appears to be cheaply available on the UK Amazon.
This supplement appears to be similar to the New Zealand blackcurrant supplement used in the mouse study, which led to a 48% reduction in CCL11.
So this supplement might be worth experimenting with, to see if it improve brain fog.
In the study, gave mice orally 10 mg/kg of a blackcurrant anthocyanin product called Currantex 30, which contains 30% total anthocyanins (this supplement is no longer available, but a similar product called CurraNZ, which is slightly stronger at 35% anthocyanins, is available to buy).
This mouse 10 mg/kg of Currantex 30 works out to a human dose of 0.81 mg/kg, which for a 75 kg person is an oral dose of around 60 mg. One CurraNZ capsule contains 300 mg, so one capsule would be 5 times the equivalent human dose in the study.