The paper is summarized with this section:
"These findings suggest that what unites and defines the EDS/HSD subtypes may not be defects in the structure and/or organization of collagen itself, but in cell adhesion to collagen. If such a notion is correct, this may provide an ideal basis for the development of a universal or non-specific diagnostic test that truly captures all EDS/HSD subtypes, irrespective of the principal underlying defect. "
One of the most interesting sentences, to me, was this:
"Speculatively, any autoimmune or inflammatory condition that promotes a general disassembly of collagen in the ECM could initiate the same pathomechanism and promote connective tissue abnormalities, which then manifest through features of joint hypermobility, skin hyperextensibility, and tissue fragility. "
It's basically saying that hEDS like symptoms could be nonspecific manifestation of an unknown autoimmune or inflammatory condition, likely including CFS.