The Enterovirus Theory of Disease Etiology in ME/CFS: A Critical Review (O'Neal and Hanson, 2021)

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Oxymatrine did not help me (my ME/CFS was triggered by CVB4), but then I also have high IgG antibodies to cytomegalovirus, suggesting I have issues with more than one virus.
That's exactly why I'm interested in a ''universal antiviral'' and I was asking you if tenofovir could also be antiviral against the enteroviruses in the other post.
Also don't get why it's being given so little attention to draco/vtose in the forums (no mention at all in discord).
 
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roller

wiggle jiggle
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but the RNA is not quite fully cleared from the cell, so then the viral RNA regrows back in the same cells once interferon therapy is over.
Pyrithione may contribute to clearance

it doesnt show this info on wiki.
it was a study. and the non-clearance had also some unbeneficial effect on nalphakappa(.?...)pathway.
 

Hip

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That's exactly why I'm interested in a ''universal antiviral'' and I was asking you if tenofovir could also be antiviral against the enteroviruses in the other post.
Also don't get why it's being given so little attention to draco/vtose in the forums (no mention at all in discord).
I have not seen any studies showing tenofovir is antiviral for enterovirus, but tenofovir might fight enterovirus by boosting the immune response. Some drugs are directly antiviral (inhibit the viral lifecycle), and others are immunomodulators which can fight infections by ramping up the immune response.

DRACO did receive some attention on this forum when its inventor Dr Todd Rider proposed it, there are some old threads on DRACO; but his research seems to have come to a halt. The idea was recently taken up by a new team in New Zealand, in the form of Vtose (see this thread). Some have considered a custom synthesis, but I would not want to be the first person to try a drug which contains a molecule that triggers apoptosis.



Pyrithione may contribute to clearance
I think you may mean this paper, which found that zinc ionophores pyrithione and hinokitiol inhibit picornavirus (the family to which enterovirus belongs).

Zinc ionophores import zinc into cells. Unfortunately zinc pyrithione (a chemical found in anti-dandruff shampoos) was found to deform the spines of rats when taken internally.

There are other zinc ionophores like EGCG and hydroxychloroquine, but I noticed no benefits from high dose EGCG (except that it has an antidepressant effect).
 
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Unfortunately, molnupiravir is a mutagenic nucleoside analogue, so there is a large risk that it will not pass safety trials. But let's certainly hope for the best!
Hey Pyrrhus, a few months have passed since you posted about Molnupiravir, and turns out it's actually doing pretty well on trials so far.

Has your position changed towards this possible treatment? Interested to hear!

Regards,
Nuno
 
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Hey Pyrrhus, a few months have passed since you posted about Molnupiravir, and turns out it's actually doing pretty well on trials so far.
Here are the published results from the Phase I trial, which reported that low doses of the drug were well tolerated:
https://journals.asm.org/doi/full/10.1128/AAC.02428-20

The question in my mind is whether the doses and dosing frequency in the trial were high enough to be effective against the coronavirus. I don't know if molnupiravir has yet been tested against any enteroviruses.