Right, one reason the side effects were severe is because Type I
interferon affects the whole body. But Type III
(lambda) works at just the organ barriers (epitheliums), like intestine, lung, etc.
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IFN Type III (Lambda) was only recently discovered.
I believe it's the absolute best shot at removing persistent Enterovirus infection.
This Type III interferon is a very potent antiviral against enterovirus, and the natural IFN III is pretty much how the body gets rid of the acute EV infection in the first place.
Problem is, those of us w/ persistent EV had (at some point) a weak enough intracellular immune response to allow EV to take hold, where it then cleaves the proteins in the infected cells in order to block
the IFN III response. That's how it evades, it blocks IFN III because IFN III will destroy it.
This is the missing link in Dr. John Chia's interferon treatments for CFS. He used IFN alpha
. People got better, then at some point they relapsed because it never destroyed the virus entirely.
IFN Lambda however has possibly the best antiviral effect on enterovirus, it works exactly where the virus is, and there are way less side effects so you can use it for longer.