@Sherpa Thank you for your reply!
I've had no tests other than the 23andme. I am very confused about what tests to take, especially because (at least with hair mineralization tests) I keep reading conflicting results about how accurate they are. I have an ND on my list to talk to, but I just want to make sure I know what tests I want.
All I know (about being an undermethylator) is how I reacted when I started taking the supps. Back when I started I was taking choline, and a b6/methyl b12/folic acid (before I knew better) combo. My body temps went back to normal, and I weaned off of my Naturthroid. Then I added in TMG, and my crashes stopped..... I could tolerate oodles of methyl b12 with no reaction, quickly had bad reactions to methylfolate. Throughout all of this I tried Ben Lynch's multi, and Amy Yasko's. The All-in-One made me feel so happy and fabulous, and then my symptoms (I know it could be something other than overmethylation) would come up.
In the beginning I would have suicidal feelings when that happened. I tried the b1/moly sulphur protocol, did the pee strips, took Optimal Start....that seemed like it was allowing me to tolerate more, but then no...
My body loved the zinc, and I loved that I was starting to be able to smell things better. Maybe that was something else. I was also taking P-5-P.
I don't have seasonal allergies, but I realized this year - because people's allergies are so bad - that my insomnia became brutal when my husband's allergies were at their peak. I do get crazy reactions to bug bites, bee stings, and poison oak. I have just started to realize that I may have a histamine thing going on. I'm not really sure how that all ties in, but I do know that I am +/+ for DAO A14747C.
It could very well be related to cortisol....or HPA axis signaling or something. Maybe my thyroid is being messed with. My temps shot way up after a day at Disneyland, and I wondered if that was because of all the adrenaline I was producing.
I have found that my husband's and my daughter's body temp goes up when they take too many methyl donors, too. I don't know if we have some special genetic thing going on, or if testing body temp is only something I'm doing. I take my temp thoughout the day when I'm on the edge to preempt getting really triggered. When I take my niacin and/or my adeno, and my temps go down, my symptoms clear. My irritability, paranoia, inflammation, drowsiness all go away.
Two weeks ago I overdid it at a new yoga class, and four days later I was really starting to crash. I took more adeno, and it was completely averted. I was singing and playing with my kids within a couple of hours.... and like I said, when I take the adeno, the niacin starts working again.
I was looking at my Sterling report again, and it has a chart showing what is happening in the Krebs cycle. I have all of the NDUF SNPs (+/-) which, if I am understanding correctly, precede the production of NAD, and somehow precedes the production of FAD...though I'm not sure how the production of FAD is impacted. I don't totally get the FAD-B2 connection, but I keep seeing that come up. Am I wrong about there being a connection?
Also, I did try taking Seriphos for my sleep. It did nothing. I liked the theanine with Relora (my husband LOVES it), but as I got better I started having a negative reaction to it. I think it was the gaba. I used to love gaba, and then stopped being able to tolerate it as I improved. Like I said, the adeno is the only thing that has actually worked (in 5 years of trying everything - homeopathy, hypnotherapy, magnesium, melatonin, tryptophan, ACV, all different herbal combos, pot, Ambien, benedryl, gaba, glycine, inositol, gelatin, honey and cinnamon, meditation, yoga, journaling, dance, and more I'm forgetting). I almost always wake up between 2 and 4:30, and I sleep through the night on adeno. Also, my brain feels like it's been cooling down/clearing since taking adeno regularly.
When I started out about a year ago, I woke in the night with yucky sweats, a couple of yoga poses could put me in bed for the rest of the day, a weekend with family would take me weeks to recover. I was depressed, anxious, and prone to being angry a lot. I felt like I had tunnel vision, my blood sugar was erratic. I hated food, but I had to eat constantly, and I had gained so. much. weight. When I was awake in the night I couldn't even meditate most of the time, because my thoughts were racing so hard. The pain in my whole body felt the worst at night, but maybe because I was so much more aware of it...
Now, my moods are so much more stable. I did a 12 hour day at Disneyland, and no crash. Not even a little one. The wrong kind and intensity of exercise can still threaten me with a crash, but I've been able to stave that off. My blood sugar has been a lot more stable for awhile now, and I've slowly lost quite a bit of weight. I hike, surf, do yoga, and take Zumba classes.. My inflammation has gone way down, and only flares sometimes (I drink tart cherry juice pretty religiously twice a day). The only symptoms left were my sleep, and being able to do any kind of exercise without crashing....
The crash thing is still lurking, and my sleep hasn't been consistently good for a terribly long time... I am craving vitamin D and magnesium, would love to take some primrose oil, but I can't without my overmethylation (0r whatever it is) symptoms flaring. And just enough adeno makes me feel like a healthy 20 year-old. My spark is back (as long as I keep it balanced).
oh...and one more confusing thing... my GI system has run pretty well throughout all of this, and since I've been taking the adeno I've been experiencing IBS symptoms.
I'm so confused.
I was just hoping that if the B2 was my issue, it would eliminate my issues with not being able to take anything else. Why did niacin work in the beginning, and why did a gradually require more and more to ameliorate my symptoms? Why does the adeno make it work again?
