It's one of those things, you will feel so bad, that you will know. My symptoms were a horrible revved up anxious/toxic type feeling. Other people have reported needing to go to the emergency room or even feeling suicidal.Thanks Caledonia! This document is really helpful to me as I'm just starting out with Dr Sarah Myhill's Methylation protocol. You talk about how to fix overmethylation but how do you know if you are overmethylating? What kind of symptoms would you get?