See following article about drugs that enhance SWS:
Enhancement of Slow Wave Sleep: Implications for Insomnia
Enhancement of Slow Wave Sleep: Implications for Insomnia
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Just giving my opinion, but I personally think changing up meds constantly day to day is not always a good idea. Nothing short of propofol (M Jackson ) will work on the bad ME/CFS nights but it's just the nature of the disease and to me it's not worth getting into the habit of having to take an entire pharmacy of additive drugs that have bad long term side effects in order to win every night.
If you find a good combo it's not going to work all the time and that's OK, it's not because it stopped working it's just the ebb and flow of the disease. Just experiment and find the right combo that works most of the time.
Chronic high evening cortisol is commonly associated with sleep disorders, fatigue, depression, weight gain in the waist, bone loss and anxiety.
My cortisol is elevated at night and that's the only clue I really have.
I am almost jealous.My insommia disappeared with overall improvement. I sleep like a baby.
When I found out mine [cortisol] was high, I was told to take Seriphos (phosphorylated serine) to help lower it. The Seriphos helped me almost immediately. I started sleeping better and felt calmer and less edgy.
I found it was best to take it in the morning in divided doses on an empty stomach. I later read that this was the best way to take it due to the way cortisol levels fluctuate throughout the day and night. We had to play around wtih the dose - I started wtih 8 capsules a day and after almost 3 years am down to 1 a day.
@CFS_for_19_years
No in the case of @andrie, it may be his elevated nighttime cortisol that prevents good sleep, and phosphatidyl serine is a good inhibitor of cortisol.
Remedies for mood or sleep problems caused by elevated cortisol:
If you are a night owl, a supplement containing a cortisol-regulating nutrient called phosphorylated serine (brand name Seriphos, this is not the more readily available phosphotidyl serine), taken before dinner (approximately four-six hours before bedtime), should get you to sleep.
If you wake up between 2:00 and 4:00AM take Seriphos at bedtime (by 10:00PM), 4-6 hours before you would typically wake up in the early morning. If you have trouble getting to sleep and you wake up between 2:00 and 4:00AM, take one capsule before dinner and two by 10:00PM. Seriphos encourages your pituitary gland to stop sending the order to your adrenals for more cortisol production. After a month or so, this normalized message should be permanently re-programmed, and you should not need any more Seriphos. Caution: Do not take Seriphos for more than three months total. Take a break for at least 24 hours after each month's use (as per bottle directions).
Phosphatidyl serine makes me super sick very very fast. I avoid it.
Indeed the best way I find, currently, for dealing with sleep issues is to sleep when I need to and can, and not worry at all about when this is.