Just giving my opinion, but I personally think changing up meds constantly day to day is not always a good idea. Nothing short of propofol (M Jackson

) will work on the bad ME/CFS nights but it's just the nature of the disease and to me it's not worth getting into the habit of having to take an entire pharmacy of additive drugs that have bad long term side effects in order to win every night.
If you find a good combo it's not going to work all the time and that's OK, it's not because it stopped working it's just the ebb and flow of the disease. Just experiment and find the right combo that works most of the time.