@Gondwanaland , may I suggest following mechanism?
B1 increases thyroid hormones (possibly by turnover from T4 to active form T3... the specifics aren't important).
However, this elevates metabolism and your adrenal gland starts kicking the dirt after a while... this new level is too stressful for adrenals, thus perhaps increased cortisol episodes like you describe.
Then you crash. This pattern certainly happens to me with any metabolism boosting supps and the stories here match it quite well. So:
B1 -> More T3 production -> More demand on adrenals and thus cortisol -> Too demanding for body, crash occurs -> Back to baseline or lower (hypothyroidism, adrenal fatigue problems)
To prove this idea:
If you want B1 to work, try it this time with supps that support adrenals. See for yourself if you start to tolerate the supplements (eg. the guy doing mag taurate with B1).
Stuff like manganese chelated, unrefined seasalt, vitamin c, potassium, magnesium, B5. Perhaps B3. They may make you feel worse initially, because your adrenals always pick up the slack
that moment your body receives those nutrients, causing an alarming but temporary symptoms. This must be especially the case if your adrenals are not in a good shape (must be true for most CFS folks). I've always experience that heart palpilations, nausea, etc when I take unrefined seassalf or normal Vit C... yet many many protocols warrant that or potassium for general detox or adrenal/metabolism/electrolyte support. This stuff is good for health.
Sometimes risk aversion or "every negative symptom now or with increased dosages means bad news" isn't always the truth. Hence people recommending the "ride it out" suggestions. We know micro-titrating is good but here we have an example of mega-doses of B1 - in a very specific sweet-spot for the individual - being the game changer for folks. But that's what it all is: taking risks and possibility of unknown calamity. Anyways, that's for my thoughts or sermon... always judge risks and possibilities.
