EddieB
Senior Member
- Messages
- 609
- Location
- Northern southern California
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Hi Jim,
Is he the one that promotes LDN?
After the dramatic reduction of symptoms yesterday from the Ativan, has me thinking that possibly some type of neuro Med could be helpful, even short term.
It sure becomes a chicken/ egg thing, as to what is causing what. I’m certain my gut bacteria/ balance is screwed up, but if the gut is consistently under neurological stress, well that’s not going to make for a healthy environment. I’m not under much external stress, but my guts are in a near constant state of tension. And I have at times struggled with anxiety/ panic attacks my entire life.
I just saw this paper and thought of this thread. It discusses the TSPO binding affinity of diazepam inducing microglia to cause cognitive impairment.
Here we report that diazepam, a widely prescribed benzodiazepine, impairs the structural plasticity of dendritic spines, causing cognitive impairment in mice. Diazepam induces these deficits via the mitochondrial 18 kDa translocator protein (TSPO), rather than classical γ-aminobutyric acid type A receptors, which alters microglial morphology, and phagocytosis of synaptic material. Collectively, our findings demonstrate a mechanism by which TSPO ligands alter synaptic plasticity and, as a consequence, cause cognitive impairment.