posted by @ljimbo423
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam.
Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases.
The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.
https://clinical-epigenetics.imedpu...azepine-receptors-and-genes-for.php?aid=19469Conclusion: Diazepam through enhancement of activity of genes responsible for synthesis of corticosterone via its stimulatory action on Peripheral Benzodiazepine Receptors (PBRs) in adrenal glands and modulating activity of immune cells could be of high pharmacological interest as a potential anti-inflammatory agent.