Cimetidine is really interesting. I'm pretty sure I'm onto something with targeting mTOR, but I don't know yet how to reconcile that with Dr Chia's work. I think that article I posted above may have some clues about pathogens hijacking the mTOR system.
Looking more closely at this CVB4 Arbidol study, and mechanism by which Arbidol (umifenovir) reduces the IL-10 secretion caused by CVB4, the full paper says that:
CVB4 virus infection reduced p38 phosphorylation, while phosphorylation of the downstream MK2 was increased. However, treatment with Umifenovir significantly promoted p38 phosphorylation and reduced MK2 phosphorylation. Therefore, we speculated that CVB4 virus infection induced IL-10 expression was mainly through the p38MAPK pathway.
So if we can further boost p38 phosphorylation (p38 activation) and reduce MK2 phosphorylation (MK2 activation) by other means as well, that may help even more to shift from Th2 to Th1 in the case of chronic coxsackievirus B4 infection.
MK2 = MAPK-activated protein kinase 2.
Seems that insulin boosts p38 activation in smooth muscle cells (so perhaps the intranasal insulin I was experimenting with might have an antiviral effect in the brain), as does follicle stimulating hormone. And genistein (a dietary supplement) reduces MK2 activation (ref: 1); but unfortunately genistein also reduces p38 activation, which is the opposite of what we want (ref: 1).
Good work, Insulin also activates mTOR. I guess I just have some healthy skepticism of the enteroviral cause of my ME/CFS. None of my titers were especially high. Looks like I am going to just pay for Rituximab through OMI for now, say 2-3 infusions to see whether I'm a responder. I may or may not be looking to augment it with antivirals and immunomodulators. There was some talk on here about Rifampin possibly being synergistic with Ritxuimab in resetting the sphingomyelin cycle. I don't really know what that means though.
Also Cimetidine apparently reduces Tregs, which disinhibits the Akt/mTOR pathway. I think that probably plays a role as well. I'm imagining trying a regimen of Oxymatrine/Rifampin/Arbidol/Cimetidine.[/QUOTE
@eljefe19 - Did you start your trail of the above mentioned regimen? If so how are you doing?