Russian Immuno-modulators

[eljefe19]

Your link is broken. I'd be interested to read the post.

 

[eljefe19]

Also Cimetidine apparently reduces Tregs, which disinhibits the Akt/mTOR pathway. I think that probably plays a role as well. I'm imagining trying a regimen of Oxymatrine/Rifampin/Arbidol/Cimetidine.

 

[eljefe19]

Cimetidine is really interesting. I'm pretty sure I'm onto something with targeting mTOR, but I don't know yet how to reconcile that with Dr Chia's work. I think that article I posted above may have some clues about pathogens hijacking the mTOR system.

 

[Hip]

Looking more closely at this CVB4 Arbidol study, and mechanism by which Arbidol (umifenovir) reduces the IL-10 secretion caused by CVB4, the full paper says that:

CVB4 virus infection reduced p38 phosphorylation, while phosphorylation of the downstream MK2 was increased. However, treatment with Umifenovir significantly promoted p38 phosphorylation and reduced MK2 phosphorylation. Therefore, we speculated that CVB4 virus infection induced IL-10 expression was mainly through the p38MAPK pathway.

So if we can further boost p38 phosphorylation (p38 activation) and reduce MK2 phosphorylation (MK2 activation) by other means as well, that may help even more to shift from Th2 to Th1 in the case of chronic coxsackievirus B4 infection.

MK2 = MAPK-activated protein kinase 2.

Seems that insulin boosts p38 activation in smooth muscle cells (so perhaps the intranasal insulin I was experimenting with might have an antiviral effect in the brain), as does follicle stimulating hormone. And genistein (a dietary supplement) reduces MK2 activation (ref: 1); but unfortunately genistein also reduces p38 activation, which is the opposite of what we want (ref: 1).

 

[eljefe19]

Good work, Insulin also activates mTOR. I guess I just have some healthy skepticism of the enteroviral cause of my ME/CFS. None of my titers were especially high. Looks like I am going to just pay for Rituximab through OMI for now, say 2-3 infusions to see whether I'm a responder. I may or may not be looking to augment it with antivirals and immunomodulators. There was some talk on here about Rifampin possibly being synergistic with Ritxuimab in resetting the sphingomyelin cycle. I don't really know what that means though.

 

[Sancar]

Also Cimetidine apparently reduces Tregs, which disinhibits the Akt/mTOR pathway. I think that probably plays a role as well. I'm imagining trying a regimen of Oxymatrine/Rifampin/Arbidol/Cimetidine.[/QUOTE

@eljefe19 - Did you start your trail of the above mentioned regimen? If so how are you doing?

 

[Nuno]

Hey @Hip , I hate to be the one bringing life to old threads, but in this one you recently (2017) mentioned that you were going to try Arbidol for its IL10 decreasing activity and antiviral properties.

Have you managed to this experiment? If so, with which results?

Thx

 

[Hip]

Hey @Hip , I hate to be the one bringing life to old threads, but in this one you recently (2017) mentioned that you were going to try Arbidol for its IL10 decreasing activity and antiviral properties.

I only did a short term test for a week at low doses, but there was one person who tried Arbidol at higher doses for longer periods, and claimed some improvement for their CVB4, if I remember correctly. You might find their posts if you search the forum for "Arbidol".

 

[Blazer95]

Ref russian peptides, has anyone tried thymogen alpha so far (Not to be confused with thymosin alpha)

 

[lngnstrng]

Ref russian peptides, has anyone tried thymogen alpha so far (Not to be confused with thymosin alpha)

yea i did. or do you really mean thymogen alpha? bc i took only the injectable one which is called thymogen https://rupharma.com/thymogen/

i also sent you a pm yesterday

 

[Blazer95]

I meant the oral thymogen Alpha one... Yeah i answered you bro

 

[mrmichaelfreedmen]

@Hip did you ever end up giving arbidol (umifenovir) another shot? Just came across this:

I tried Arbidol at a high dose for many months with out much if any success.

I also tried injectable cycloferon, it boosted NK cell numbers on my blood work but did not help with any of my CFS symptoms.

I also tried injectable Interferon Alpha, this had very minimal positive effects.

I have a strongly positive 2+ stomach biopsy from Dr Chia.

Keep testing Positive for a fungal Infection that is a biofilm producing form of Candida which powerful antifungals can’t touch - Which basically pours mycotoxins into my body.

I strongly believe that our bodies are too toxic to heal, as I have had some success immediately following “detox” protocols with very basic supplements.

 

[Blazer95]

In Case anyone is interested:

Substances Up to a molecular weight of 500 Daltons are Said to be nasal/sublingual bioavailable.

Thymogen has a molecular weight of roundabout 200 Daltons, while Thymosin Alpha has 3.000 Daltons i believe.

I did Test a small dosage of thymogen (250mcg) sublingual today and i felt worse soon after. it could a similar herx Like experience Like in thymosin alpha.

I will continue experimenting with thymogen sublingual as it seems i get a systemic effect/reaction from it.

Cheers

 

[Carl]

I tried Arbidol at a high dose for many months with out much if any success.

I also tried injectable cycloferon, it boosted NK cell numbers on my blood work but did not help with any of my CFS symptoms.

I also tried injectable Interferon Alpha, this had very minimal positive effects.

I have a strongly positive 2+ stomach biopsy from Dr Chia.

Keep testing Positive for a fungal Infection that is a biofilm producing form of Candida which powerful antifungals can’t touch - Which basically pours mycotoxins into my body.

I strongly believe that our bodies are too toxic to heal, as I have had some success immediately following “detox” protocols with very basic supplements.

You need a suitable Quorum Sensing Inhibitor and then take something like Interfase with 2 size 0 caps of EDTA. Also add some Serrapeptase and Nattokinase might also help or Lumbrokinase if you can afford it.
QSI and Efflux Pump Inhibitors are very closely related and EPI's will inhibit their efflux pumps which should make antifungals more effective against them. BFB-1 and BFB-2 are good but mainly for bacterial QSI and EPI use but they might also work against Candida but I haven't checked that because I don't have any known issues with Candida. If you search for Efflux Pump and Candida you should get some hits. You just need to use suitable things to defeat their biofilm and then use a strong antifungal.

There are many EPI's on pubmed Central. Amikacin which is an antibiotic is supposed to have effects against Candida Efflux Pumps. It looks like Candida might use ABC Efflux Pumps and there is a herb which is effective at deactivating ABC Efflux Pumps but it can affect BP and can promote depression. Reserpine from Rauwolfia serpentina is the compound which is effective against some ABC transporters.

farnesol
fusidic acid
pantoprazole - PPI & haloperidol - antipsychotic used for anxiety
Natural Compounds: A Hopeful Promise as an Antibiofilm Agent Against Candida Species - This lists a few things against Candida biofilms including Thymol which is present in one of BFB-1 or BFB-2. Carvacrol is also listed in that article and that is also in one of BFB-1/BFB-2. It is also present in Oregano essential oil. Eugenol is another which is in Clove essential oil which is also in BFB-1 or BFB-2. Cinnamaldehyde from Cinnamon essential oil and in tiny amounts in Ceylon Cinnamon, I don't think that is in BFB1/2. You will need to check what essential oils are in BFB-1 & 2 because they contain a different selection of essential oils. There will be many others natural Candida EPI's and QSI's. BFB-1 & BFB-2 are stated to be used externally but that is probably to work around laws in the US and the FDA. I have used them myself internally. Candida can share a biofilm with gram positive bacteria therefore they might not be alone. I recommend that you look for some strong herbs against Candida and gram +ve and gram -ve bacteria and hit the lot. It will be uncomfortable when the biofilm drops but you might be very surprised with the result.

There are many herbs with strong effects against Candida and their biofilms. Once you have successfully dropped the biofilm destroying them should be fairly easy.
@mrmichaelfreedmen

​

 

[EddieB]

I have a strongly positive 2+ stomach biopsy from Dr Chia.

Please pardon the interruption, but I stumbled upon this. You’re the first person (besides myself) that I’ve found with a positive biopsy from Dr Chia. Could you please dm me, to discuss. Thanks.

 

[mrmichaelfreedmen]

You need a suitable Quorum Sensing Inhibitor and then take something like Interfase with 2 size 0 caps of EDTA. Also add some Serrapeptase and Nattokinase might also help or Lumbrokinase if you can afford it.
QSI and Efflux Pump Inhibitors are very closely related and EPI's will inhibit their efflux pumps which should make antifungals more effective against them. BFB-1 and BFB-2 are good but mainly for bacterial QSI and EPI use but they might also work against Candida but I haven't checked that because I don't have any known issues with Candida. If you search for Efflux Pump and Candida you should get some hits. You just need to use suitable things to defeat their biofilm and then use a strong antifungal.

There are many EPI's on pubmed Central. Amikacin which is an antibiotic is supposed to have effects against Candida Efflux Pumps. It looks like Candida might use ABC Efflux Pumps and there is a herb which is effective at deactivating ABC Efflux Pumps but it can affect BP and can promote depression. Reserpine from Rauwolfia serpentina is the compound which is effective against some ABC transporters.

farnesol
fusidic acid
pantoprazole - PPI & haloperidol - antipsychotic used for anxiety
Natural Compounds: A Hopeful Promise as an Antibiofilm Agent Against Candida Species - This lists a few things against Candida biofilms including Thymol which is present in one of BFB-1 or BFB-2. Carvacrol is also listed in that article and that is also in one of BFB-1/BFB-2. It is also present in Oregano essential oil. Eugenol is another which is in Clove essential oil which is also in BFB-1 or BFB-2. Cinnamaldehyde from Cinnamon essential oil and in tiny amounts in Ceylon Cinnamon, I don't think that is in BFB1/2. You will need to check what essential oils are in BFB-1 & 2 because they contain a different selection of essential oils. There will be many others natural Candida EPI's and QSI's. BFB-1 & BFB-2 are stated to be used externally but that is probably to work around laws in the US and the FDA. I have used them myself internally. Candida can share a biofilm with gram positive bacteria therefore they might not be alone. I recommend that you look for some strong herbs against Candida and gram +ve and gram -ve bacteria and hit the lot. It will be uncomfortable when the biofilm drops but you might be very surprised with the result.

There are many herbs with strong effects against Candida and their biofilms. Once you have successfully dropped the biofilm destroying them should be fairly easy.
@mrmichaelfreedmen

​

Thanks for your message.

I’ve used serrapeptase and NAC throughout my Voriconazole protocol for 2 years and testing still comes back positive for Candida Parapillosis.

Interphase just arrived today. Thank you for the pubmed link on natural biofilm busters! Will reread your message when am feeling less cloudy.

Ps have arranged an appointment with a local expert on botanicals to assist with identifying something that might help clear my viral infection or both infections.

 

[mrmichaelfreedmen]

Please pardon the interruption, but I stumbled upon this. You’re the first person (besides myself) that I’ve found with a positive biopsy from Dr Chia. Could you please dm me, to discuss. Thanks.

What would you like to know? Although @Hip is wayyy more knowledgeable than I am.

 

[Carl]

Thanks for your message.

I’ve used serrapeptase and NAC throughout my Voriconazole protocol for 2 years and testing still comes back positive for Candida Parapillosis.

Interphase just arrived today. Thank you for the pubmed link on natural biofilm busters! Will reread your message when am feeling less cloudy.

Ps have arranged an appointment with a local expert on botanicals to assist with identifying something that might help clear my viral infection or both infections.

Do not forget the EDTA, it's very inexpensive and it soaks up any minerals that are release from the biofilm so that they cannot reuse them to rebuild the biofilm. BTW there are two different types of Interfase. There is Interfase and there is Interfase plus. The Interfase plus contains a small amount of EDTA, which is insufficient IMO and it wastes space in the capsule which means you get less of the important enzymes. I did start with Interfase+ but later moved to Interfase. I used separate capsules of EDTA with both. The Interfase+ capsules are not better, they are only more convenient and they might be slightly cheaper because of the lower amounts of enzymes.

Quorum Sensing Inhibition - QSI's are important because using them would slow down their ability to rebuild the biofilm and would give the antimicrobials/antifungals more time to destroy the pathogens. QSI's and EPI's are almost the same and have very similar effects so any EPI's should also have QSI effects. EPI's will inhibit the Candida's ability to eliminate antifungals and make the antifungals effects many times greater.

I recommend using the Interfase none plus capsules and fill some EDTA capsules for use with it.

I recommend that you look for some EPI's which are effective against Candida because they will improve the effectiveness of ANY antifungals that you take.

Stephen Harrod Buhner has a book called Herbal Antivirals which might be worth "getting" a copy or eBook copy. He does also have a book called Herbal Antibiotics which is very good but I don't think it covers Candida being a yeast/fungi but it might assist with any bacterial pathogens which shouldn't be underestimated IMO.

A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin - find this research paper
Herbal Antivirals - Natural Remedies for Emerging & Resistant Viral Infections, 2nd Edition - Stephen Harrod Buhner
That book has quite a lot of information on the herbs that it lists. It has has fairly detailed information on Chinese Skullcap (root) and compares other members of the Skullcap family.
Chinese Skullcap has a number of beneficial effects against viruses and can be used with Licorice which also has some antiviral effects. It can decrease the CYP3A4 Liver enzyme which can cause the level of drugs to increase in the system - be aware of this. It is also a strong P-glycoprotein inhibitor which can make more drugs be absorbed into the system through the digestive system. It can also help reduce cancerous cells from eliminating anti cancer drugs.

 

[EddieB]

What would you like to know? Although @Hip is wayyy more knowledgeable than I am.

I suppose I would ask about your symptoms. Do you have digestion troubles? Did you also do ARUP blood testing? I did and it was normal, no ev found there.

 

[mrmichaelfreedmen]

I suppose I would ask about your symptoms. Do you have digestion troubles? Did you also do ARUP blood testing? I did and it was normal, no ev found there.

Yes, chronic dyspepsia, lack of appetite. Fat malabsorption. Dr Chia has actually published a paper on this (EV and digestion problems)

I also have an extremely leaky gut, as testing has shown. Have tried Multiple gut repair formulas with no help. My guess is the gut can't heal with a chronic fungal and viral infection.

No blood testing for me, just a strongly positive VP1 stain/stomach biopsy. I am 100% sure this is the cause of my chronic fatigue syndrome.