Monoclonal IFNa antibodies is what they are talking about here. Sifalimumab is one, used for Systemic Lupus Erythematosus.
Ron Davis Update
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Monoclonal IFNa antibodies is what they are talking about here. Sifalimumab is one, used for Systemic Lupus Erythematosus.
I think I sort of, kind of understand the hypothesis. What I don't get is why they are assuming that this metabolic state is aberrant and not a result of an ongoing low grade infection somewhere in the tissues?
It's not like we all get checked for all possible infections in all possible locations in the body using 100% accurate test methods.
What i got is that they want to figure out what is causing it and mentioned several times it could be an active infection.
But if they have the science down even an active infection should involve the active immune system, not perpetually the short term immune startup system.
That said i am not yet sold on this current theory, it makes a lot of intuitive sense but it lacks any real evidence and their data is too vague.
When I first started quercetin, I got a big relief in malaise and sympathetic drive
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I see though that quercetin upregulates Ifn-alpha so that doesn't seem ideal per this study? I'm not very well versed on any of this.
The previous comment about beta glucans bypassing itaconate is interesting, and there were also some studies where mice with an induced CFS improved with beta glucans. But I think enough people have had beta glucans that we'd know by now?
*shrug* Maybe someone else has a better understanding. Grateful for the research and hopeful for the future.
Yes, assuming the immune system is functioning correctly, which it probably isn't in CFS.
BrightCandle
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I definitely improve with the intake of beta glucans, if I don't take them I get immediately worse. This is one of the few things I take I am 100% sure works. The best form for me so far is just plain old Oats, usually in bran format rather than whole oats as raw works a lot better than cooked. The other fancier solutions like Reishi and Lions Mane mushroom work too but aren't better and they cost more. I have no doubt beta glucans help me and I have about half the amount in my gut as a normal person according to my recent biomesight.
Mary
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Could you be specific about what symptoms beta glucans help you with? e.g., do they help prevent PEM or increase your endurance or improve brain fog, etc. I am glad to hear beta glucans are helping you - I like oat bran a lot!
BrightCandle
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Fatigue, energy levels and headaches. Seems to help my gut function too.
What dose do you take?
@janetdafoe in case this Itaconate work from Japan is relevant https://apple.news/AJhkrZ8h-Q0WXRaInOFOAWg
Kuniyuki Aso et al, Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming, Nature Communications (2023). DOI: 10.1038/s41467-023-36594-x
Kuniyuki Aso et al, Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming, Nature Communications (2023). DOI: 10.1038/s41467-023-36594-x
@Janet Dafoe
in case this Itaconate work from Japan is relevant https://apple.news/AJhkrZ8h-Q0WXRaInOFOAWg
Kuniyuki Aso et al, Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming, Nature Communications (2023). DOI: 10.1038/s41467-023-36594-x
in case this Itaconate work from Japan is relevant https://apple.news/AJhkrZ8h-Q0WXRaInOFOAWg
Kuniyuki Aso et al, Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming, Nature Communications (2023). DOI: 10.1038/s41467-023-36594-x