Hi Rich - TY for your analysis.
***Hi, Jeffrez. You're welcome.
My alt doc is in MA, I'm going in a couple weeks, think I'll see if they can order & run the methylation panel from there. I assume the results will be faster that way than waiting for everything to go to Europe and back?
***Probably so.
Is any special test kit required, or can we just send standard blood draws from MA and have HD take care of it using those & a credit card #?
***Yes, there's a special kit. The vials have a proprietary combination of enzyme blockers in them, which is what preserves glutathione from all becoming oxidized after it is taken out of the body.
In the meantime, think I will reduce mb12 even more, down to around 1mg, with the intent of switching over to hydroxy as soon as I can order and receive that. Without the sublingual mb12, my b12 was almost totally wiped out, but I was also on the omeprazole at that time, so it's hard to say if it's from intrinsic factor deficiency or b/c of the drug. Either way, think I feel more comfortable with hydroxy at this point, as the IVs I had with mb12 seemed to cause side effects, the first time even lasting for a couple weeks. The hydroxy IVs by contrast have been fine.
***O.K.
I didn't think folate conversion was an issue for me, b/c I get the same super low heart rate and depression symptoms both from methylfolate and standard folic acid. But maybe there is some issue there slowing down conversion, which I suppose is very hard to say w/out the meth panel. Otoh, I don't seem to get those symptoms from the folate in the B-right, strangely enough, which is why I was taking that - to at least be getting some supplemental folate. If it's not converting though, or converting too slowly to be effective, I guess it's just counterproductive at this point, and I should dump the B-right for one of the non-folate B-complexes and start micro-dosing the methylfolate.
Does all that sound right, or at least reasonable? : P
***I think it does.
Was hoping to avoid the methylation panel b/c of the expense, but it might be better to just put all guesswork aside and know for sure. Can you say with certainty that there would be distinct advantages from a treatment standpoint from having the test, as opposed to just trial and error and seeing what works clinically, and with standard labs guiding me as far as the folate & b12 levels?
***I think it's best to know what you're dealing with. The standard blood serum tests for folate and B12 are not very useful in ME/CFS.
Btw, I also have low CD8, high EBV, and some other infections - mycoplasma pneumoniae, etc. Think we're going to work on treating those at my next visit, as I'm sure those are playing into this presumed GSH-depletion problem, also.
***I think you're right about that. It looks to me now that it is necessary to do methylation treatment as well as going after the infections specifically.
***I hope this works out well for you.
***Best regards,
***Rich
***Hi, Jeffrez. You're welcome.
My alt doc is in MA, I'm going in a couple weeks, think I'll see if they can order & run the methylation panel from there. I assume the results will be faster that way than waiting for everything to go to Europe and back?
***Probably so.
Is any special test kit required, or can we just send standard blood draws from MA and have HD take care of it using those & a credit card #?
***Yes, there's a special kit. The vials have a proprietary combination of enzyme blockers in them, which is what preserves glutathione from all becoming oxidized after it is taken out of the body.
In the meantime, think I will reduce mb12 even more, down to around 1mg, with the intent of switching over to hydroxy as soon as I can order and receive that. Without the sublingual mb12, my b12 was almost totally wiped out, but I was also on the omeprazole at that time, so it's hard to say if it's from intrinsic factor deficiency or b/c of the drug. Either way, think I feel more comfortable with hydroxy at this point, as the IVs I had with mb12 seemed to cause side effects, the first time even lasting for a couple weeks. The hydroxy IVs by contrast have been fine.
***O.K.
I didn't think folate conversion was an issue for me, b/c I get the same super low heart rate and depression symptoms both from methylfolate and standard folic acid. But maybe there is some issue there slowing down conversion, which I suppose is very hard to say w/out the meth panel. Otoh, I don't seem to get those symptoms from the folate in the B-right, strangely enough, which is why I was taking that - to at least be getting some supplemental folate. If it's not converting though, or converting too slowly to be effective, I guess it's just counterproductive at this point, and I should dump the B-right for one of the non-folate B-complexes and start micro-dosing the methylfolate.
Does all that sound right, or at least reasonable? : P
***I think it does.
Was hoping to avoid the methylation panel b/c of the expense, but it might be better to just put all guesswork aside and know for sure. Can you say with certainty that there would be distinct advantages from a treatment standpoint from having the test, as opposed to just trial and error and seeing what works clinically, and with standard labs guiding me as far as the folate & b12 levels?
***I think it's best to know what you're dealing with. The standard blood serum tests for folate and B12 are not very useful in ME/CFS.
Btw, I also have low CD8, high EBV, and some other infections - mycoplasma pneumoniae, etc. Think we're going to work on treating those at my next visit, as I'm sure those are playing into this presumed GSH-depletion problem, also.
***I think you're right about that. It looks to me now that it is necessary to do methylation treatment as well as going after the infections specifically.
***I hope this works out well for you.
***Best regards,
***Rich