Pyrrhus
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Interestingly, many patients with Long Covid report that they never tested positive on any antibody tests.
The following CDC study tried to determine why some people don't seem to develop antibodies after a SARS-CoV-2 infection, even though they tested positive on a PCR test. (a phenomenon called non-seroconversion) Apparently, this phenomenon might be much more prevalent than imagined, calling into question some key assumptions of some key studies...
Predictors of Nonseroconversion after SARS-CoV-2 Infection (Liu et al., Sept. 2021)
https://wwwnc.cdc.gov/eid/article/27/9/21-1042_article
Excerpt:
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The following CDC study tried to determine why some people don't seem to develop antibodies after a SARS-CoV-2 infection, even though they tested positive on a PCR test. (a phenomenon called non-seroconversion) Apparently, this phenomenon might be much more prevalent than imagined, calling into question some key assumptions of some key studies...
Predictors of Nonseroconversion after SARS-CoV-2 Infection (Liu et al., Sept. 2021)
https://wwwnc.cdc.gov/eid/article/27/9/21-1042_article
Excerpt:
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2–specific antibodies. [...] Initial serosurveys identified antibodies in nearly 100% of persons with [PCR]–confirmed SARS-CoV-2 infection (5). However, more recent studies have shown that seroconversion rates are surprisingly variable (6–10). For example, a multicenter study from Israel reported that 5% of participants remained seronegative despite a positive [PCR] test result on a nasal swab specimen (6). In contrast, a seroprevalence study from New York found that 20% of persons with a positive [PCR] test result did not seroconvert (8). Another study from Germany reported that 85% of confirmed infected COVID-19 contacts failed to develop antibodies (9).