dreampop
Senior Member
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Genuinely wondering, what actually is the concrete evidence of CDR in CFS/ME? In Naviaux's paper he calls CFS the opposite of CDR ("chronic CDR"), so we probably shouldn't even call it that. However, the specifics of that were not all replicated - for example, the shingolipids, which were a major abnormality in that study. There are many aspects of cellular danger signaling, but I've not seen any evidence that are elevated in CFS (DAMPS, NLRP3). I'm sure some are intracellular and some are local to the just outside the cell. But if you look on his original paper of metabolic features of CDR, the metabolic features of CFS are not the opposite of summer metabolism. Perhaps most importantly, it shows ATP being more intracellular.
And even more strangely, he recommends suramin for CDR, but also CFS, when he says they are opposites. I think his suggestion is that, "a postexposure adaptation or mitocellular hormesis" (whatever that is) gears the cells to the opposite of CDR response through the same CDR pathways, esp purinergic. Buy you can't just make every pathway do the opposite.Well, I really assume you can't. How could an entire series of very different pathways be downregulated when they are encoded by different genes.
@Murph You could read Naviaux original paper on CDR, it talks about mTOR being the summer fuel sensor and AMPK being the winter fuel sensor. I believe per his talk at the OMF summit, he believes we were in winter metabolism.
Maybe I've hopelessly misunderstood everything.
And even more strangely, he recommends suramin for CDR, but also CFS, when he says they are opposites. I think his suggestion is that, "a postexposure adaptation or mitocellular hormesis" (whatever that is) gears the cells to the opposite of CDR response through the same CDR pathways, esp purinergic. Buy you can't just make every pathway do the opposite.Well, I really assume you can't. How could an entire series of very different pathways be downregulated when they are encoded by different genes.
@Murph You could read Naviaux original paper on CDR, it talks about mTOR being the summer fuel sensor and AMPK being the winter fuel sensor. I believe per his talk at the OMF summit, he believes we were in winter metabolism.
Maybe I've hopelessly misunderstood everything.
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