@Murph, I keep coming back to phosphorylation and low adenosine - so I'm back on the coffee I've been reading the old original potato apyrase experiments which talk about ATP and the way it competitively interacts with ADP, AMP and adenosine. I wondered if this is the metabolic trap Phair was talking about - ATP getting in the way of other metabolic processes which require phosphorylation (such as ubiquinone), particularly at the PANX 1 channel. So as a little experiment, I started using glycyrrhetinic acid (licorice extract) as a PANX1 inhibitor - to slow down ATP into the extracellular space - and hence the p2x7 responsiveness. It's been a week (and I've started slow) I have less lactic acid and much more energy. I had a flare of what I think of as p2x3 responses - wide spread pain, trigeminal nerve issues, gut distention issues ect ect. I'm taking ALA for that but it takes awhile to take effect. All over, I'm feeling much better.