So, the only abnormalities in my labs besides viral titers my doc interpreted as high, were low immunoglobulin, high IgE, and high eosinophils. My doctor and naturopath both suggested that the eosinophils and IgE were connected, she suggested it's related to some mast cell thing.
Why do I bring this up? Well, I just started to explore the connections between histamine, mast cells, and purinergic signalling.
I found two papers so far that illuminate these connections. Also, apparently there's a journal just dedicated to purinergic signalling.
I don't really understand the connections so far, but I'm really just trying to gather information that may be relevant for a sharper mind to pick through. Will run it by my grandfather that did cancer research.
Also, as i mentioned earlier, the role of microglia and TLR4 in neuroinflammation that low dose naltrexone is thought to affect may be related to mast cells, I'm finding a lot of key words that are similar.
the abstract on the second paper:
"Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and antitumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system."
re: the bolded part, is it possible that some asthma drugs could be useful in CFS?