Learner1
Senior Member
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NMN is definitely useful. I take 125-187mg daily. @bertiedog my apologies for missing this thread earlier, but the NR folks, who profit from their high priced product, are very aggressive about slamming NMN and NAD+.
I've found NR Does absolutely nothing for me, I think because of a mutation on NMRK1 and 2, but NMN and NAD+ are both effective for me .
NMN requires less conversion to get to NAD+ than NR, as you can see by the picture below, and NAD+ is the stuff we use.
I've found NR Does absolutely nothing for me, I think because of a mutation on NMRK1 and 2, but NMN and NAD+ are both effective for me .
Entrez Gene Summary for NMRK1 Gene
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008
NMN requires less conversion to get to NAD+ than NR, as you can see by the picture below, and NAD+ is the stuff we use.