Yes looking at the overall paper they stated that the disrupted pathways were FAD dependent and that in turn was disease dependent. This could simply indicate their subjects had either chronic infection, or chronic immune activation.
I agree the body changes response when a situation goes from acute to chronic. E.g. Thyroid output raises in acute illness but lowers in chronic illness.
My first thought too Alex both on reading the cholesterol and Uric Acid data. Also way too many patients from one clinic.
He's a a psychiatrist, expecting he to know the difference is really naughty of you Denise ;-)
Funny, I described the unconscious state I go into in PEM as nearer hibernation than sleep when my Endo was getting cocky some time ago.
One obvious example would be diversion of Tryptophan from Serotonin production to the kynurenine pathway thus promoting rest and isolation.
I vaguely remember that lactic acid produced during exercise plays a part in strengthening muscle. Given that Myhill unearthed two groups of M.E. patients with poor ATP production and one group utilised anaerobic energy production that produced excess lactic acid - that might also explain it. Guess we have two possibilities?
We did start producing a rating scale in a thread, and evaluating the existing scales some time ago. I took the view we needed something that rated separate functions very explicitly and calculated an end result.
I had a related issue in mind. If you take ample Vitamin C, you body makes less Uric Acid because oxidative stress is lower and it's unnecessary.
I find that side effects build up over time. When I came off fluoxetine it took six weeks for its effect to dissipate. I'm inclined to think we are slow to metabolise and eliminate drugs hence the side effects at higher doses.It's possible that this isn't directly related to how we metabolize pills, but that our bodies have gotten used to very low levels of different metabolites. Our receptors have shot up in sensitivity over time, which is what happens to anyone who has 'low' anything over time. Now, one little particle of adrenaline settling into a receptor shoots us into the stratosphere.
When we take a normal amount of a drug, to our hypersensitive cells, the effect is amplified many times over.
If you'll allow me a metaphor: a plant hasn't been watered in weeks. You pour a gallon of water over it, it doesn't perk up, it dies. Too much, too soon.
Re: HIV. The more I learn about HIV, the more similarities I see between the two. (Important differences as well.) I'm beginning to see why researchers like Klimas study both, and why clinically, both me and my mother were frequently told, "okay, this is going to be hard to hear, but I think you might have HIV."
My mother must've been tested six or seven times, because anytime she saw a new doctor they just assumed she was in the early phases, and that's why she hadn't tested positive previously.
from an evolutionary perspective sick cave men can collect less food, a lower metabolic rate would spare energy.
put simply the p value is the probability that a conclusion may be wrong. Ideally we want numbers more like p<0.005I'm not sure about that Simon. I'm pretty sure that a p value of 0.15 does mean that there's a 15% likelihood that it's due to chance.
I wasn't familiar with q values but it looks like they're used to correct the p value for multiple comparisons and result in a marginally less stringent level of confidence than the p value :
http://www.science.smith.edu/cmbs/wp-content/uploads/sites/36/2015/09/P-and-q-values-in-RNA-Seq.pdf
So - thanks - I've learned something
The vast majority were Northern California and appear to be patients of one clinic! That could mean similar dietary interventions etc. I have driven two hundred miles in the USA and found the same houses, same crops grown, same accent, same food in restaurants. In. Britain you would see vast differences. The distances are not comparable.
Fancy taking the blood sample from a hibernating bear KME?
Adrenal, how does that process work? My understanding was that Mitochondria have an expected six week life span and increase by division?
A lot needs to be done and it takes funding. I believe this next study has ME/CFS patients from all over N America with age and gender and region matched healthy controls. Of course we also need to differentiate between different diseases as soon as we can.
