NAC adverse effects [POLL, multiple votes allowed]

[pamojja]

Sodium ascorbate is also taken IM, and that allegedly can hurt. Always differentiate route of application.

 

[lyran]

Emphasis to alternative co-factor nutrients added by me. What is your experience with those?

Ubiquinol (Q10 in its active form) was very effective at first when I started taking it years ago but nowadays I don't notice anything even from big doses. I can take thiamine when I combine it with vitamin B2 in its active form. Otherwise I get the sulfur symptoms so there is a connection there. I haven't noticed anything when I take magnesium, zinc or choline. I still take magnesium daily. Zinc seems to cause constipation so I try to get it from food.

This is offtopic but I developed GERD in March. It is terrible to have GERD with CFS/ME and I don't respond all that well to PPI:s. Pepcid (famotidine) worked at first but it is losing its effectivenes. It sucks when having CFS/ME and you can't even sleep at night because of constant intestinal symptoms like constant bloating and belching and acid shooting straight to my throat and even ears. I get constant adrenaline rushes also because of this that keeps me awake. I think there is vagus nerve connection there.

I fixed my diet and realised that high FODMAP foods are triggers for me. I don't get much heartburn when I don't consume them but all the other symptoms still remain. Probably Candida and/or SIBO is causing all this and there may be the sulfur and poor detoxification connection to all this.

I tried betaine HCL and apple cider vinegar tablets but they both made my GERD symptoms even worse. Taking apple cider vinegar tablet was like dropping a mentos tablet into Coca Cola bottle.

 

[linusbert]

interestingly i have a problem with thiamine, i did a couple injections and they would hurt like crazy every time.
i took a bottle of glutathione and it had no effect whatsoever (same with coQ10) but i read it has terrible bioavailability iirc

depends on the form, s-acetyl-glutathione is good. normal glutathion usually is split in the guts but then can be later composed together.
but if normal glutathion which is a sulfur compound does not make problems, maybe you have a different problem. maybe the acetyl- group is your problem instead? for example thiamin often is bound to acetyl groups as well as in benfothiamine.

if acetyl groups are your problem, try some normal L-carnitine or L-carnitine-fumarate.

 

[linusbert]

I tried betaine HCL and apple cider vinegar tablets but they both made my GERD symptoms even worse. Taking apple cider vinegar tablet was like dropping a mentos tablet into Coca Cola bottle.

if thats the case it could be too much acid and not to less. you might try some hydrogencarbonated mineralwater. above 1000mg/l.
but careful, it might with time lead to too less acid, when you get the stone like feeling in your stomach then its that.

 

[Rufous McKinney]

NAC like every other sulfur based supplement increases my fatigue, causes headache and flu like symptoms

felt lousy for the entire month I swallowed thirty of those NAC. I figure I have to feel lousy before I ever feel better.

 

[Rufous McKinney]

It is terrible to have GERD with CFS/ME

Very sorry to hear this is happening, I totally agree it really sucks.

could the vagus nerve be involved in the GERD?

 

[bad1080]

i started my desensitization today with 75mg (1/20 of the recommended max. dose of 1500mg), let's see how this goes

 

[lyran]

Very sorry to hear this is happening, I totally agree it really sucks.

could the vagus nerve be involved in the GERD?

Yes I think it is involved (gut-brain connection).

 

[bad1080]

Yes I think it is involved (gut-brain connection).

please make a separate thread for this, thank you!

 

[Mary]

I've got to get to the other side of this detoxing somehow.

@bad1080, @Rufous McKinney - I used to have serious problems with detoxing. I would detox at the drop of a hat - anything that had "cleansing" properties (apple cider vinegar, cayenne) would make me feel sick. Chlorella wiped me out, and had a very strong detox reaction to infrared sauna.

I credit my chiropractor who does muscle testing for getting me out of this hole. In 2003 he found my liver was quite toxic with chemical solvents from a job I'd had when I was 19. I did a liver detox under his supervision. At the time I was having trouble eating before noon, just felt sick all the time ( in addition to PEM etc.) It was bad. The liver detox took 30 days, it was pretty rough and at the end of it my digestion was very much improved. I also learned I needed to take betaine HCL with pepsin regularly and I also added in milk thistle at this time. Prior to then one glass of wine would make me sick for an entire day and 2 glasses would make me sick for 3 days. Now I can drink like a "normal" person.

The chiro did all this using muscle testing.

However, for many years after this, I'd still react quite strongly to lots of things (ACV, cayenne, I can't remember everything which hit me). A detox foot bath wiped me out for 3 days. Chlorella caused a severe detox reaction - I think I was "retoxing" - toxins would get mobilized by chlorella and then just circulate in my system and get redeposited.

In 2014 or 2016 (?) I took some gelatin at night hoping to help with sleep. Gelatin is very high in glycine and I'd read that glycine could help with sleep. Well, it knocked me for a loop - had a severe detox reaction, got very spacey (got lost going to my sister's house), very tired, digestion upset, all the usual stuff. I figured well, I can't take that again! But am v. glad I asked my chiro about it - he did his testing and found that glycine actually was good for me but in a much smaller dose. So I took glycine in v. small doses, gradually increasing as tolerated for 6 months, and at the end of 6 months I no longer reacted badly to it. I also did the same thing with inositol and glutamine at the same time - both caused detoxing but much milder than the glycine.

I read about glycine during all of this and learned that it was important for Phase II liver detoxification and inositol and glutamine were as well, to a lesser extent. I've taken glycine ever since at night because I do think it helps a bit with sleep, and muscle testing indicates it's good for me. Without the muscle testing, I never would have touched glycine again because of my severe detox reaction.

And I no longer react to everything on the planet. The last time I had a detox reaction was a few years after all that when I had a new (vinyl) bathroom floor put in and that made me feel a bit sick for about 3 days and that was it. I really don't react to anything any more, and prior to all this it had been a weekly occurrence. I wasn't always sure what I was reacting to but it was always something.

Without the chiropractor and muscle testing I never would have been able to figure this out. I still have ME/CFS of course and crash regularly when overdoing things, but at least detoxing is one awful symptom I no longer have to deal with.

 

[Mary]

i added a poll to the thread, it'd be much appreciated if you'd take part in it if you tried NAC. it's up to two votes (one for "yes" and one for what you did after having side-effects, or just one for "no"), thanks in advance!

@bad1080 - I just discovered your poll by accident today as it's not mentioned in the title of your thread. If you like I can edit the title of your thread to add the word "poll" to it - I think it might get more attention that way. (Or however you might like it edited)