- Messages
- 38
So, no silver bullet here- we completed a 10 day trial of Rapamune and had no noticeable improvement.
We ordered 30 pills for about $190 on 5-2-17 from ( https://www.allgenericmedicine.com/product/rapamune-1mg/601 ) and received them in Colorado on 5-18-17. The hope was that they were as represented on the web site and were brand name Wyeth Rapamune- they weren't. We received a manilla envelope containing 5 blister packs of 6 pills marked as Sirolimus made by Emcure Pharmaceuticals. In an attempt to verify what we got I sacrificed one pill to test the only physical property I could without a lab, I ground up a pill and tested it's solubility in water and ethanol. As per the properties of Rapamune it was not soluble in water and was in ethanol, I guessed it was the real stuff.
We started with 1mg. per day for the first three days with no improvement, we then added a glass of grapefruit juice with the 1 pill for 3 days. As per this study ( https://news.uchicago.edu/article/2...ice-lets-patients-take-lower-dose-cancer-drug ) the grapefruit juice increases the absorption by a factor of about 3. We then increased to 2 pills per day plus the grapefruit juice for 4 days (an effective dose of 6mg. per day). At the end of the 10 days there was no reduction in any of my wife”s major or secondary symptoms so we stopped the Rapamune but on day 12 she woke up with mouth ulcers which took about 3 days to clear up. Mouth ulcers are the most common reported side effect of Rapamune so we're guessing it was in fact the real drug and she was absorbing it.
Once again, I am either treating or torturing her, I just don't know which until it's over.
On a positive note- we started anti-viral treatment with Arbidol immediately after stopping the Rapamune and her IRIS or herx reaction was almost zero for the first week of Arbidol, it has since come back but it was nice for her not to have any additional suffering with the anti-viral for awhile. I am uncertain about using the Rapamune with the Arbidol and I'm still investigating the possible interactions
For those considering using Rapamune there are some interesting discussions about the dangers relative to the dosage on these web sites-
https://rapamycintherapy.com/
https://joshmitteldorf.scienceblog.com/2016/06/13/rapamycin-redux/
http://www.longecity.org/forum/topi...ifespan-anyone-experimenting-with-this/page-1
The life extension people are very interested in Rapamune/Sirolimus/Rapamycin and there are several people using low dosage pulsing treatment in N=1 testings
We ordered 30 pills for about $190 on 5-2-17 from ( https://www.allgenericmedicine.com/product/rapamune-1mg/601 ) and received them in Colorado on 5-18-17. The hope was that they were as represented on the web site and were brand name Wyeth Rapamune- they weren't. We received a manilla envelope containing 5 blister packs of 6 pills marked as Sirolimus made by Emcure Pharmaceuticals. In an attempt to verify what we got I sacrificed one pill to test the only physical property I could without a lab, I ground up a pill and tested it's solubility in water and ethanol. As per the properties of Rapamune it was not soluble in water and was in ethanol, I guessed it was the real stuff.
We started with 1mg. per day for the first three days with no improvement, we then added a glass of grapefruit juice with the 1 pill for 3 days. As per this study ( https://news.uchicago.edu/article/2...ice-lets-patients-take-lower-dose-cancer-drug ) the grapefruit juice increases the absorption by a factor of about 3. We then increased to 2 pills per day plus the grapefruit juice for 4 days (an effective dose of 6mg. per day). At the end of the 10 days there was no reduction in any of my wife”s major or secondary symptoms so we stopped the Rapamune but on day 12 she woke up with mouth ulcers which took about 3 days to clear up. Mouth ulcers are the most common reported side effect of Rapamune so we're guessing it was in fact the real drug and she was absorbing it.
Once again, I am either treating or torturing her, I just don't know which until it's over.
On a positive note- we started anti-viral treatment with Arbidol immediately after stopping the Rapamune and her IRIS or herx reaction was almost zero for the first week of Arbidol, it has since come back but it was nice for her not to have any additional suffering with the anti-viral for awhile. I am uncertain about using the Rapamune with the Arbidol and I'm still investigating the possible interactions
For those considering using Rapamune there are some interesting discussions about the dangers relative to the dosage on these web sites-
https://rapamycintherapy.com/
https://joshmitteldorf.scienceblog.com/2016/06/13/rapamycin-redux/
http://www.longecity.org/forum/topi...ifespan-anyone-experimenting-with-this/page-1
The life extension people are very interested in Rapamune/Sirolimus/Rapamycin and there are several people using low dosage pulsing treatment in N=1 testings
