Microbiome - Butyrate - Inflammation

LINE

LINE

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I should add that peppermint and ginger have been perennial favorites. They can tone down some of the disruptions :)

Boswellia (frankincense) gets a star as well -good anti-inflammatory and has antibiotic properties as well.
 
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Violeta

Violeta

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I am back to dealing with pathogens. I got out my pau d'arco and olive leaf for my dog who is too itchy, and started drinking it, too. I might add some lemon balm, we'll see how long I can keep up the momentum.

I do take red panax ginseng, too, and find it very helpful. I did read that it has to be the fermented type, too. It actually says that in studies done on it. You have to be so careful when you buy it because the type that is white is not the right thing, but they call it red ginseng, too. I bought one before I figured out that it wasn't actually "red", and it did not work as well as the red fermented type. I buy Prince of Peace brand. The one you are taking looks good, too.

I hadn't read about ginseng impacting the gut. That's good news.

I still have some of the akkermansia I bought several months ago. I just take inulin every now and then. I don't notice much with the probiotic approach, either.

Mostly I am focusing on liver with choline and taurine, and just recently started ascorbyl palmitate. Vitamin C deficiency was one of my first very obvious symptoms from way back when I was a kid. We'll see if it helps more than regular ascorbic acid.
 
vortex

vortex

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170
Violeta said:
@LINE,
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@Violeta I

I am interested in finding out why levels of asparagine in people with ME/CFS are lower than normal.
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Very interesting you bring up asparagine!

Oxaloacetate is a precursor for asparagine and Oxaloacetate is known to be low in ME/CFS

There is an Oxaloacetate supplement called Benagene.
Probably best to supplement with it and see if asparagine comes up also.

I have tested low for asparagine on my CMA intracellular nutrient and also metabalomics test iollo
Both showed low asparagine.

You can run the amino acid profile from labcorp for cheaper though.


thoughts?
 
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vortex

vortex

Senior Member
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170
@Violeta
My Asparagine levels in blood, low!
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vortex

vortex

Senior Member
Messages
170
Violeta said:
Did you have low levels of anything else?
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Yes, Serine levels. This was on the iollo.com test.

I also ran the CMA test which showed a few other things low like glutathione etc.

Are you going to supplement with asparagine or oxaloacetate?
 
Violeta

Violeta

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3,421
vortex said:
Yes, Serine levels. This was on the iollo.com test.

I also ran the CMA test which showed a few other things low like glutathione etc.

Are you going to supplement with asparagine or oxaloacetate?
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Neither, at this point. I'm trying to figure out what is causing the problem.

Keep us posted on you do with it.
 
Violeta

Violeta

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That's a good clue. Did the place where you read about that say what causes oxaloacetate deficiency?

When I have the mental energy I look at the Kreb's cycle and try to figure out what is causing an oxaloacetate deficiency. Someone told me NAD is important, but didn't say why. Maybe that's why.

Right now, it's after 7 PM and my brain isn't working. If you have any more leads, let me know.

1741219853991.png
 
Violeta

Violeta

Senior Member
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3,421
vortex said:
How do you feel about the oxaloacetate deficiency causing it since it is a precursor?
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Did your report mention aspartate?

Oxaloacetate is a precursor to asparagine, as it's first converted to aspartate through transamination, and then aspartate is converted to asparagine by asparagine synthetase.

Here's a more detailed explanation:
  • Oxaloacetate and Aspartate:
    Oxaloacetate, a key intermediate in the citric acid cycle, can be converted to aspartate through transamination, a process where an amino group is transferred from glutamate to oxaloacetate, catalyzed by the enzyme aspartate aminotransferase.

  • Aspartate and Asparagine:
    Aspartate is then converted to asparagine by the enzyme asparagine synthetase, which uses ATP to activate aspartate, forming β-aspartyl-AMP. Glutamine donates an ammonium group, which reacts with β-aspartyl-AMP to form asparagine and free AMP.
 
vortex

vortex

Senior Member
Messages
170
Violeta said:
Did your report mention aspartate?

Oxaloacetate is a precursor to asparagine, as it's first converted to aspartate through transamination, and then aspartate is converted to asparagine by asparagine synthetase.

Here's a more detailed explanation:
  • Oxaloacetate and Aspartate:
    Oxaloacetate, a key intermediate in the citric acid cycle, can be converted to aspartate through transamination, a process where an amino group is transferred from glutamate to oxaloacetate, catalyzed by the enzyme aspartate aminotransferase.

  • Aspartate and Asparagine:
    Aspartate is then converted to asparagine by the enzyme asparagine synthetase, which uses ATP to activate aspartate, forming β-aspartyl-AMP. Glutamine donates an ammonium group, which reacts with β-aspartyl-AMP to form asparagine and free AMP.
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No, neither the CMA or the iollo did not show aspartate.

But the cheapest test, the amino acid from labcorp that I took 7 years ago did show it but it is old, so the numbers arent accurate.
I guess I will re-run this test.

https://www.lifeextension.com/lab-testing/itemlc700068/amino-acid-profile-blood-test
 
vortex

vortex

Senior Member
Messages
170
Violeta said:
That's a good clue. Did the place where you read about that say what causes oxaloacetate deficiency?

When I have the mental energy I look at the Kreb's cycle and try to figure out what is causing an oxaloacetate deficiency.
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Have you run an organic acid test?
They are a good way to look at blocks in your krebs cycle, you can literally see a buildup at the block and a deficiency in the next step.
Often CFS shuts down the krebs cycle from aconitase which is glutathione dependant, so you will see a block there.
 
Violeta

Violeta

Senior Member
Messages
3,421
vortex said:
Have you run an organic acid test?
They are a good way to look at blocks in your krebs cycle, you can literally see a buildup at the block and a deficiency in the next step.
Often CFS shuts down the krebs cycle from aconitase which is glutathione dependant, so you will see a block there.
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No, I have never done one. Where do you go for the blood draw?
 
vortex

vortex

Senior Member
Messages
170
Violeta said:
No, I have never done one. Where do you go for the blood draw?
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The OAT test is a urine test.

Providers are:
Mosaic https://mosaicdx.com/test/organic-acids-test/
Genova https://connect.gdx.net/products/nutrition-organic-acids
Vibrant Wellness https://vibrant-wellness.com/test/OrganicAcids
US Biotek https://www.usbiotek.com/organic-acids-testing

You usually need a doctor to order or you can buy these online through resellers, just google it

I also ran across a new one from realtime, I cant vouch for it but it looks affordable
https://realtimelab.com/organic-acids-profile/
 
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Violeta

Violeta

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Messages
3,421
I need to find a good doctor.

The doctors in my area that I think would help in this area make you pay a down payment to be part of their "group". It's usually aroun $1500.
 
vortex

vortex

Senior Member
Messages
170
Violeta said:
I need to find a good doctor.

The doctors in my area that I think would help in this area make you pay a down payment to be part of their "group". It's usually aroun $1500.
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help in what area? to order the OAT test?

I said you can buy these online through resellers, just google it
 
LINE

LINE

Senior Member
Messages
977
Location
USA
Violeta said:
That's a good clue. Did the place where you read about that say what causes oxaloacetate deficiency?

When I have the mental energy I look at the Kreb's cycle and try to figure out what is causing an oxaloacetate deficiency. Someone told me NAD is important, but didn't say why. Maybe that's why.

Right now, it's after 7 PM and my brain isn't working. If you have any more leads, let me know.

View attachment 55372
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NAD+ could be a good choice -- it participates in the NADH pathway - I suspect that the problems are due to high oxidative stress mainly caused by immune activation. Oxidative stress (oxidants) inhibits a multitude of metabolic pathways,

I bought NAD+ in liposomal form.
 
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