Microbiome - Butyrate - Inflammation

[Violeta]

@LINE, did you take an antibiotic for the gastro issue?

I don't know if this would apply, but it is interesting.

LPS-induced inhibition of salivation appears to be caused by increased PGE production. Diminished salivary secretion produces poor oral health; thus the use of COX-2 inhibitors to counteract the effects of inhibited salivation should be considered.

The COX-2 inhibitors would just be a band aid, but the LPS-induced inhibition of salivation is interesting.

 

[Violeta]

Combined effect of vitamin C and vitamin D3 on intestinal epithelial barrier by regulating Notch signaling pathway​

https://pmc.ncbi.nlm.nih.gov/articles/PMC8105975/

Thus, our results demonstrate that an appropriate amount of vitamin C combined with vitamin D3 can regulate the expression of claudin-2 by regulating Notch-1, relieve destruction of the intestinal mucosal barrier, and promote the repair of damage to the cell mucosal barrier.

 

[Violeta]

Fucoidan for tight junctions is something worth considering.

Fucoidan, a bioactive substance extracted from brown algae, can affect epithelial cells in a number of ways, including:

• Intestinal epithelial cells
  Fucoidan can improve the barrier function of intestinal epithelial cells. This is done by increasing the trans-epithelial resistance (TER) of polarized Caco-2 cell monolayers.

Fucoidan is a sulfated polysaccharide found in brown seaweeds that can interact with immune cells to produce mucin and enhance the immune response:

• Immune response
  Fucoidan can interact with Toll-like receptors on immune cells to produce mucin and improve the immune response. It can also promote the activation of immune effector cells and regulate the intestinal immune barrier.

 

[LINE]

Fucoidan for tight junctions is something worth considering.

Fucoidan, a bioactive substance extracted from brown algae, can affect epithelial cells in a number of ways, including:

• Intestinal epithelial cells
  Fucoidan can improve the barrier function of intestinal epithelial cells. This is done by increasing the trans-epithelial resistance (TER) of polarized Caco-2 cell monolayers.

Fucoidan is a sulfated polysaccharide found in brown seaweeds that can interact with immune cells to produce mucin and enhance the immune response:

• Immune response
  Fucoidan can interact with Toll-like receptors on immune cells to produce mucin and improve the immune response. It can also promote the activation of immune effector cells and regulate the intestinal immune barrier.

Fucoidan is an excellent choice - good for the tight junction proteins - very good detoxifying agent, will pull toxins out, toxins attack the tight junction proteins, so they (toxins) are not good. If I remember correctly, the Russians used brown algae (fucoidan) following the Chernobyl incident. It was reported that it able to detoxify radiation. It has also been mentioned in journal articles in the role of cancer. It is not expensive.

I get good to very good results with a similar product which is Amazing Grass Supergreens. It has chlorella with spirulina then they add moringa and kale. Perhaps the action is similar due to the spirulina and chlorella. I did brown algae for a bit, but likely did not take long enough.

*brown algae is rich in alginates - alginates act like a sponge to draw toxins out.

 

[Violeta]

Fucoidan is an excellent choice - good for the tight junction proteins - very good detoxifying agent, will pull toxins out, toxins attack the tight junction proteins, so they (toxins) are not good. If I remember correctly, the Russians used brown algae (fucoidan) following the Chernobyl incident. It was reported that it able to detoxify radiation. It has also been mentioned in journal articles in the role of cancer. It is not expensive.

I get good to very good results with a similar product which is Amazing Grass Supergreens. It has chlorella with spirulina then they add moringa and kale. Perhaps the action is similar due to the spirulina and chlorella. I did brown algae for a bit, but likely did not take long enough.

*brown algae is rich in alginates - alginates act like a sponge to draw toxins out.

Yes, and I've used it in the past and have had some sitting in my cabinet for a two years. I had put it aside and moved on to something else. I do that very frequently. But I got it back out again and started taking it after realizing this new benefit it provides. Yes, I think the spriulina and chlorella have a similar action of detoxification and providing of important nutrients.

You are correct, it was used by Russian following the Chernobyl incident. I have the product Modifilan, which is made by a man from Russia and was actually used for that purpose.

It's also a good source of iodine. Lots of good reasons to take it. I just ordered more.

Thank you for this thread and taking the time for updates and responses. It's been a big help to me.

 

[LINE]

Thank you for this thread and taking the time for updates and responses. It's been a big help to me.

You are welcome - nice to know that someone is reading

Something worth reading is Rehmannia - this is one of the prized Chinese herbs, I think it is a flower. I never heard of it despite trying and reading a number of Chinese formulas. I bought Planetary Formulas Rehmannia Endurance, it was inexpensive. It supports a number of processes in the body and particular the gut, I think it targets the mucous membrane which is showing up as a vital part of the immune response.

I gave a sample to a co-worker and he has reported similar results. No significant problems to report so far.

That formula is based on a 1,000-year-old Chinese formula. So far, the formula has smoothed energy where it seemed to stop the complete fatigue (exhaustion) and provided a smoother energy curve (more stabilized). I have read a number of journal articles of rehmannia effects in the gastrointestinal tract and the formula contains plantain which is another studied herb for gut health.

Whether it works for everyone is questionable, but for $10, it was an easy choice. *

====== Article on rehmannia and gastro: the article discusses the herb in relation to colitis but the bigger issue is the ability for it to reshape the microbiota and butyrate production.

https://pubmed.ncbi.nlm.nih.gov/36347632/

Results: The results showed that rehmannia attenuates lipopolysaccharide-induced overexpression of inflammatory factors, improves tight junction proteins to protects the tightness of the intestinal epithelium; , inhibits the expression of inflammatory factors through the NF-kB (nuclear factor-kappa B pathway, and improved the of intestinal tissues inflammation.

It can maintain the species diversity of intestinal microbes, increase the content of short-chain fatty acids and then restore the imbalance of intestinal microecology.

*that formula contains some other herbs which may or may not be beneficial. Perhaps just rehmannia by itself? As mentioned, the formula also contains plantain which is another studied herb for gastro issues.