Nutrition deficiencies will always vary of course as we all have unique differences in diet etc, however what I'm suggesting is that the nutritional deficiencies brought on by ongoing stressors to the body can lead to all the cascade of symptoms of ME/CFS, just a bit of it here to start. Magnesium is required for over 300 enzyme systems that regulate diverse biochemical reactions in the body including being necessary as well for production of ATP energy. Copper is required for completing the electron transport in the mitochondria where our energy is produced, and it is required to be attached to ceruloplasmin to be usable at all by the body. It no longer will be attached well to ceruloplasmin when adrenals become too weak from the stress making you low or deficient of copper even though copper is being taken in, Zinc is also very important for metallothionein (MT) synthesis. One of MTs vital roles is to bind to copper for enhancement of utilization or for removal and excretion. Without adequately absorbed dietary zinc, MT synthesis is impaired, further allowing copper (along with other toxins and metals) to build up. Without this zinc, excess copper builds up in tissues which then interferes particularly with the liver and digestion, among other systems as well. A vicious cycle is then created, because as liver / bile function and digestive processes decline, meat protein becomes less tolerable. Without adequate zinc, the individual lacks the ability to retain potassium.
Adequate potassium is necessary for hydrochloric acid secretion in the stomach. Copper toxic individuals very often will also have gut concerns, including candida and yeast, low HCl, poor nutrient absorption, gluten sensitivity, even leaky gut. One of copper's roles is that of an anti-fungal, and when in balance, helps to control fungi and yeast / candida in the gut. However, with toxic levels of copper, much of this copper is in a bio-unavailable form stored in tissues, and is not serving it's role in controlling the candida / yeast, or other parasites. This, along with the anaerobic GI environment that's created, allows candida, fungi, yeast, parasites and bacteria to flourish. Meanwhile, as mentioned above, copper toxicity (by way of lowering zinc) also reduces hydrochloric acid production. When hydrochloric acid (HCl) is low, the healthy gut flora are weakened (and zinc is lowered further - a vicious cycle). HCl helps kill off pathogens and is required for the absorption of nutrients such as calcium, iron, and various vitamins. Reduced digestive enzyme production occurs and the intestine becomes overly alkaline, giving a nice home to pathogenic bacteria. Copper toxicity leads to low HCl by way of slowing metabolism and reducing sodium and potassium levels, two minerals which are required in the production of HCl. The destruction of gut function and the collapse of one's metabolism are hallmarks of copper toxicity. Long term copper-induced zinc deficiency will increase the permeability of the gut lining, contributing to leaky gut and food intolerances.
As copper and mercury and other metals begin to accumulate its further putting more stress on the adrenals until the nutrients are depleted and burnout occurs. Low cortisol (HPA axis dysfunction) is one end result of those depleted nutrients (adrenal burnout phase).
https://forums.phoenixrising.me/ind...of-women-with-chronic-fatigue-syndrome.60069/ - Here you see that most CFS patients have low cortisol, which is the end result of depleted nutrients from the various potential stress triggers.
Copper if its high can also deplete vitamin c and molybdenum. Mercury from amalgams is slowly released, the rate is doubled by wifi/radiofrequency exposure, plus is in most all seafood these days. Mercury happens to also deplete zinc and magnesium as well as attach to selenium, cause issues with iodine, nitric oxide, na-k-atpase and much more. B vitamins are depleted with stress and have important functions all throughout the body.
TH1 is later supressed and allows viruses to reactivate, which would be an additional issue that some face with CFS. Apparently this can lead to depletion of CoQ10 for example.
https://www.selfhacked.com/blog/homing-fundamenal-cause-epstein-barr-reactivation/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277319/ zinc deficiency and immunity
Issues with anxiety, depression can be caused by lack of any one of the magnesium, zinc, b6, an excess of copper depleting the things with an X.
https://understand-andcure-anxietya...pression.com/images/MelatoninCopperBlocks.jpg
Here is some information on some of the details of the stress process and effects on the body.
https://forums.phoenixrising.me/index.php?posts/980149/
https://coppertoxic.com/adrenals
https://coppertoxic.com/flowchart - click to enlarge, zoom controls on lower right then.
https://remedygrove.com/misc/Hypercupremia-High-Copper
https://www.drlam.com/articles/adrenalexhaustion.asp
All of this from nutrient deficiencies as you can see.
Alcohol is simply another stressor that happens to have an even bigger release of cortisol then a stress event. Caffeine is a stressor, heavy metals like copper and mercury are usually involved, anger, chronic illness, depression, surgery, high sugar intake, over exercise,
sleep deprivation, chronic or acute infections including Giardia and H. pylori and root canal repair are all treated the same with the release of cortisol and adrenaline, starting the cycle. A list of life stressors.
https://www.health24.com/Mental-Health/Stress/Stress-management/41-major-life-stressors-20120721