Methylcobalamin I.M. and S.C. injections equivalance to sublingual form

Thinktank

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I've been searching for this but couldn't find a definitive answer. Hope some of you want to share their opinion / expertise.

Have there been any studies done on the bio-equivalance between the different application forms of methylcobalamin? By that i mean intramusculair vs. subcutaneous vs sublingual.
I know that oral has bad bio-availability, especially in those with inflammation in the ileum.

I've just received 10 X 1mg/ml vials methylcobalamin which i'd like to start with today but have to decide I.M. or S.C.
 

Helen

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One injection every second day, 2 ml = 10 mg MeCbl.
(One needle to draw up (right expession?) the liquid and then another very thin and short to inject with. Search for a spot on the skin where the needle doesn´t hurt and there you can inject without any pain. The front of the tigh use to be a good place).
 

Thinktank

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@ahmo, thanks i will take a look at it.
I gave it a go this morning and injected 1mg metylCbl subcutaneously per Dr. Neubranders injection recommendation.
In an hour i felt a lift in mood and actually haven't felt this good in a whole month. I didn't expect anything from it so it's no placebo, have i gone too deep with the needle? I don't believe real S.C. should give such a rapid response.

@Helen, thanks again for your advice.
 

Helen

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I´m happy to read that you had such a good response. I have heard quite a few stories like yours, and my own first reaction was very strong too. I don´t think you have to worry about how deep you injected the MeCbl. It worked :) .
 

Thinktank

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The MethylB12 subcutane injection worked better than expected.

I did some basic labtesting before starting my IV ceftriaxone treatment for lyme 5 days ago.
My HCT is too low. Does anyone know why that might be the case, anything to do with methylation?

HCT = 42.8 (43.5 - 53.7)
MCV = 87.5 (80.0 - 95.0)
MCH = 30.5 (27.0 - 32.5)
MCHC = 34.8 (32.0 - 36.0)
RBC: 4.89 (4.5 - 6.0)
RBC distr. width = 13.7% (9.0 - 15.0)
 

Thinktank

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Last months labtest revealed my HCT increased slightly to the borderline level of 43.6%.
This month it has dropped to 41.6%.

I inject 10mg hydroxycobalamin twice weekly and take 400mcg metafolin daily so what's going on?
 
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I've been trying the methyl b12 in sublingual with the methylfolate and lcarnitine fumarate and haven't noticed a big difference (also b complex SC injections). Hydroxy b12 is also prescribed for cyanide poisoning and reduced cyanide levels by 50% or more in cigarette smokers. I read in one study rocephin can severely damage your gallbladder by interacting with calcium and forming large gallstones. by the way is there a site to purchase cheap methyl b12 injections?